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Protein

60 kDa chaperonin

Gene

groL

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBQUI283165:GHZA-1073-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Heat shock protein 60
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
Ordered Locus Names:BQ10750
OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
Taxonomic identifieri283165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000597 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 54754760 kDa chaperoninPRO_0000063284Add
BLAST

Proteomic databases

PRIDEiO33964.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi283165.BQ10750.

Structurei

3D structure databases

ProteinModelPortaliO33964.
SMRiO33964. Positions 2-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiMLTTDCA.
OrthoDBiPOG091H00E7.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKEVKFGR EARERLLRGV DILANAVKVT LGPKGRNVVI DKSFGAPRIT
60 70 80 90 100
KDGVSVAKEI ELEDKFENMG AQMLREVASK TNDIAGDGTT TATVLGQAIV
110 120 130 140 150
QEGVKAVAAG MNPMDLKRGI DAAVEEVVGN LFKKAKKIQT SAEIAQVGTI
160 170 180 190 200
SANGAAEIGK MIADAMEKVG NEGVITVEEA KTAETELEVV EGMQFDRGYL
210 220 230 240 250
SPYFVTNADK MVADLDDPYI LIHEKKLSNL QSLLPVLEAV VQSGKPLLII
260 270 280 290 300
AEDVEGEALA TLVVNKLRGG LKIAAVKAPG FGDRRKAMLE DIAILTSGQV
310 320 330 340 350
ISEDVGIKLE NVTLDMLGRA KKVNISKENT TIIDGAGKKA EINARVNQIK
360 370 380 390 400
VQIEETTSDY DREKLQERLA KLAGGVAVIR VGGATEVEVK EKKDRVDDAL
410 420 430 440 450
NATRAAVEEG IVAGGGTALL RAANALAIKG SNPDQEAGIN IVRRALQAPA
460 470 480 490 500
RQIATNAGEE AAIIVGKVLE NNADTFGYNT ATGQFGDLIA LGIVDPVKVV
510 520 530 540
RSALQNAASI ASLLITTEAM VAEVPKKDTP MPPMPGGGMG GMGGMDF
Length:547
Mass (Da):57,610
Last modified:January 1, 1998 - v1
Checksum:i8620CFC50BF2D6F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78515 Genomic DNA. Translation: AAB69095.1.
BX897700 Genomic DNA. Translation: CAF26542.1.
RefSeqiWP_011179743.1. NC_005955.1.

Genome annotation databases

EnsemblBacteriaiCAF26542; CAF26542; BQ10750.
KEGGibqu:BQ10750.
PATRICi31953529. VBIBarQui58630_1169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78515 Genomic DNA. Translation: AAB69095.1.
BX897700 Genomic DNA. Translation: CAF26542.1.
RefSeqiWP_011179743.1. NC_005955.1.

3D structure databases

ProteinModelPortaliO33964.
SMRiO33964. Positions 2-526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283165.BQ10750.

Proteomic databases

PRIDEiO33964.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF26542; CAF26542; BQ10750.
KEGGibqu:BQ10750.
PATRICi31953529. VBIBarQui58630_1169.

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiMLTTDCA.
OrthoDBiPOG091H00E7.

Enzyme and pathway databases

BioCyciBQUI283165:GHZA-1073-MONOMER.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH60_BARQU
AccessioniPrimary (citable) accession number: O33964
Secondary accession number(s): Q6FYV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.