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Protein

60 kDa chaperonin

Gene

groL

Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-1348-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Heat shock protein 60
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
Ordered Locus Names:BH13530
OrganismiBartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000421 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 54754760 kDa chaperoninPRO_0000063283Add
BLAST

Proteomic databases

PaxDbiO33963.
PRIDEiO33963.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi283166.BH13530.

Structurei

3D structure databases

ProteinModelPortaliO33963.
SMRiO33963. Positions 2-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiMLTTDCA.
OrthoDBiPOG091H00E7.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33963-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKEVKFGR EARERLLRGV DILANAVKVT LGPKGRNVVI DKSFGAPRIT
60 70 80 90 100
KDGVSVAKEI ELEDKFENMG AQMLREVASK TNDIAGDGTT TATVLGQAIV
110 120 130 140 150
QEGVKAVAAG MNPMDLKRGI DAAVDEVVAN LFKKAKKIQT SAEIAQVGTI
160 170 180 190 200
SANGAAEIGK MIADAMEKVG NEGVITVEEA KTAETELEVV EGMQFDRGYL
210 220 230 240 250
SPYFVTNAEK MVADLDDPYI LIHEKKLSNL QSLLPVLEAV VQSGKPLLII
260 270 280 290 300
AEDVEGEALA TLVVNKLRGG LKIAAVKAPG FGDRRKAMLE DIAILTSGQV
310 320 330 340 350
ISEDVGIKLE NVTLDMLGRA KKVNISKENT TIIDGAGQKS EINARVNQIK
360 370 380 390 400
VQIEETTSDY DREKLQERLA KLAGGVAVIR VGGATEVEVK EKKDRVDDAL
410 420 430 440 450
NATRAAVEEG IVAGGGTALL RAANALTVKG SNPDQEAGIN IVRRALQAPA
460 470 480 490 500
RQIATNAGEE AAIIVGKVLE NNADTFGYNT ATGEFGDLIA LGIVDPVKVV
510 520 530 540
RSALQNAASI ASLLITTEAM VAEVPKKDTP VPPMPGGGMG GMGGMDF
Length:547
Mass (Da):57,625
Last modified:January 1, 1998 - v1
Checksum:iEDE25D566D5B10D2
GO

Sequence cautioni

The sequence AAD04238 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78514 Genomic DNA. Translation: AAB69094.1.
AJ749669 Genomic DNA. Translation: CAG44447.1.
BX897699 Genomic DNA. Translation: CAF28126.1.
AF014829 Genomic DNA. Translation: AAD04238.1. Different initiation.
U96734 Genomic DNA. Translation: AAB65637.1.
RefSeqiWP_011181151.1. NZ_LRIJ01000002.1.

Genome annotation databases

EnsemblBacteriaiCAF28126; CAF28126; BH13530.
KEGGibhe:BH13530.
PATRICi20546723. VBIBarHen29080_1481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78514 Genomic DNA. Translation: AAB69094.1.
AJ749669 Genomic DNA. Translation: CAG44447.1.
BX897699 Genomic DNA. Translation: CAF28126.1.
AF014829 Genomic DNA. Translation: AAD04238.1. Different initiation.
U96734 Genomic DNA. Translation: AAB65637.1.
RefSeqiWP_011181151.1. NZ_LRIJ01000002.1.

3D structure databases

ProteinModelPortaliO33963.
SMRiO33963. Positions 2-526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283166.BH13530.

Proteomic databases

PaxDbiO33963.
PRIDEiO33963.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF28126; CAF28126; BH13530.
KEGGibhe:BH13530.
PATRICi20546723. VBIBarHen29080_1481.

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiMLTTDCA.
OrthoDBiPOG091H00E7.

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-1348-MONOMER.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH60_BARHE
AccessioniPrimary (citable) accession number: O33963
Secondary accession number(s): O87267
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.