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Protein

Glucose-1-phosphatase

Gene

agp

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Active sitei40 – 401NucleophileBy similarity
Binding sitei43 – 431SubstrateBy similarity
Binding sitei116 – 1161SubstrateBy similarity
Binding sitei218 – 2181SubstrateBy similarity
Active sitei312 – 3121Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: InterPro
  2. glucose-1-phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1126-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphatase (EC:3.1.3.10)
Short name:
G1Pase
Gene namesi
Name:agp
Ordered Locus Names:STM1117
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 413391Glucose-1-phosphatasePRO_0000023949Add
BLAST

Proteomic databases

PaxDbiO33921.
PRIDEiO33921.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi99287.STM1117.

Structurei

3D structure databases

ProteinModelPortaliO33921.
SMRiO33921. Positions 23-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG28269.
HOGENOMiHOG000118851.
KOiK01085.
OMAiFQRWHDK.
OrthoDBiEOG64N9T2.
PhylomeDBiO33921.

Family and domain databases

Gene3Di3.40.50.1240. 3 hits.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O33921-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSLLAVAV AGAVLLSSAV QAQTTPEGYQ LQQVLMMSRH NLRAPLANNG
60 70 80 90 100
SVLAQSTPNA WPAWDVPGGQ LTTKGGVLEV YMGHYTREWL VAQGLIPSGE
110 120 130 140 150
CPAPDTVYAY ANSLQRTVAT AQFFITGAFP GCDIPVHHQE KMGTMDPTFN
160 170 180 190 200
PVITDDSAAF RQQAVQAMEK ARSQLHLDES YKLLEQITHY QDSPSCKEKH
210 220 230 240 250
QCSLIDAKDT FSANYQQEPG VQGPLKVGNS LVDAFTLQYY EGFPMDQVAW
260 270 280 290 300
GGIHTDRQWK VLSKLKNGYQ DSLFTSPTVA RNVAAPLVKY IDKVLVADRV
310 320 330 340 350
SAPKVTVLVG HDSNIASLLT ALDFKPYQLH DQYERTPIGG QLVFQRWHDG
360 370 380 390 400
NANRDLMKIE YVYQSARQLR NAEALTLKSP AQRVTLELKG CPVDANGFCP
410
LDKFDNVMNT AAK
Length:413
Mass (Da):45,559
Last modified:December 13, 2001 - v2
Checksum:iE057667CF8A7244C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571T → P in AAC45604 (PubMed:9260936).Curated
Sequence conflicti60 – 634AWPA → TCPP in AAC45604 (PubMed:9260936).Curated
Sequence conflicti74 – 741K → T in AAC45604 (PubMed:9260936).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20049.1.
U75949 Genomic DNA. Translation: AAC45604.1.
RefSeqiNP_460090.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20049; AAL20049; STM1117.
GeneIDi1252635.
KEGGistm:STM1117.
PATRICi32380673. VBISalEnt20916_1182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20049.1.
U75949 Genomic DNA. Translation: AAC45604.1.
RefSeqiNP_460090.1. NC_003197.1.

3D structure databases

ProteinModelPortaliO33921.
SMRiO33921. Positions 23-413.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1117.

Proteomic databases

PaxDbiO33921.
PRIDEiO33921.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20049; AAL20049; STM1117.
GeneIDi1252635.
KEGGistm:STM1117.
PATRICi32380673. VBISalEnt20916_1182.

Phylogenomic databases

eggNOGiNOG28269.
HOGENOMiHOG000118851.
KOiK01085.
OMAiFQRWHDK.
OrthoDBiEOG64N9T2.
PhylomeDBiO33921.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1126-MONOMER.

Family and domain databases

Gene3Di3.40.50.1240. 3 hits.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  2. "A Salmonella typhimurium genetic locus which confers copper tolerance on copper-sensitive mutants of Escherichia coli."
    Gupta S.D., Wu H.C., Rick P.D.
    J. Bacteriol. 179:4977-4984(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-249.
    Strain: TN1379.

Entry informationi

Entry nameiAGP_SALTY
AccessioniPrimary (citable) accession number: O33921
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 13, 2001
Last modified: January 7, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.