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O33921

- AGP_SALTY

UniProt

O33921 - AGP_SALTY

Protein

Glucose-1-phosphatase

Gene

agp

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (13 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391SubstrateBy similarity
    Active sitei40 – 401NucleophileBy similarity
    Binding sitei43 – 431SubstrateBy similarity
    Binding sitei116 – 1161SubstrateBy similarity
    Binding sitei218 – 2181SubstrateBy similarity
    Active sitei312 – 3121Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: InterPro
    2. glucose-1-phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-1126-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-1-phosphatase (EC:3.1.3.10)
    Short name:
    G1Pase
    Gene namesi
    Name:agp
    Ordered Locus Names:STM1117
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 413391Glucose-1-phosphatasePRO_0000023949Add
    BLAST

    Proteomic databases

    PaxDbiO33921.
    PRIDEiO33921.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi99287.STM1117.

    Structurei

    3D structure databases

    ProteinModelPortaliO33921.
    SMRiO33921. Positions 23-413.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG28269.
    HOGENOMiHOG000118851.
    KOiK01085.
    OMAiFQRWHDK.
    OrthoDBiEOG64N9T2.
    PhylomeDBiO33921.

    Family and domain databases

    Gene3Di3.40.50.1240. 3 hits.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O33921-1 [UniParc]FASTAAdd to Basket

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    MKKSLLAVAV AGAVLLSSAV QAQTTPEGYQ LQQVLMMSRH NLRAPLANNG    50
    SVLAQSTPNA WPAWDVPGGQ LTTKGGVLEV YMGHYTREWL VAQGLIPSGE 100
    CPAPDTVYAY ANSLQRTVAT AQFFITGAFP GCDIPVHHQE KMGTMDPTFN 150
    PVITDDSAAF RQQAVQAMEK ARSQLHLDES YKLLEQITHY QDSPSCKEKH 200
    QCSLIDAKDT FSANYQQEPG VQGPLKVGNS LVDAFTLQYY EGFPMDQVAW 250
    GGIHTDRQWK VLSKLKNGYQ DSLFTSPTVA RNVAAPLVKY IDKVLVADRV 300
    SAPKVTVLVG HDSNIASLLT ALDFKPYQLH DQYERTPIGG QLVFQRWHDG 350
    NANRDLMKIE YVYQSARQLR NAEALTLKSP AQRVTLELKG CPVDANGFCP 400
    LDKFDNVMNT AAK 413
    Length:413
    Mass (Da):45,559
    Last modified:December 13, 2001 - v2
    Checksum:iE057667CF8A7244C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571T → P in AAC45604. (PubMed:9260936)Curated
    Sequence conflicti60 – 634AWPA → TCPP in AAC45604. (PubMed:9260936)Curated
    Sequence conflicti74 – 741K → T in AAC45604. (PubMed:9260936)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20049.1.
    U75949 Genomic DNA. Translation: AAC45604.1.
    RefSeqiNP_460090.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20049; AAL20049; STM1117.
    GeneIDi1252635.
    KEGGistm:STM1117.
    PATRICi32380673. VBISalEnt20916_1182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20049.1 .
    U75949 Genomic DNA. Translation: AAC45604.1 .
    RefSeqi NP_460090.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali O33921.
    SMRi O33921. Positions 23-413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM1117.

    Proteomic databases

    PaxDbi O33921.
    PRIDEi O33921.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20049 ; AAL20049 ; STM1117 .
    GeneIDi 1252635.
    KEGGi stm:STM1117.
    PATRICi 32380673. VBISalEnt20916_1182.

    Phylogenomic databases

    eggNOGi NOG28269.
    HOGENOMi HOG000118851.
    KOi K01085.
    OMAi FQRWHDK.
    OrthoDBi EOG64N9T2.
    PhylomeDBi O33921.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-1126-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1240. 3 hits.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.
    2. "A Salmonella typhimurium genetic locus which confers copper tolerance on copper-sensitive mutants of Escherichia coli."
      Gupta S.D., Wu H.C., Rick P.D.
      J. Bacteriol. 179:4977-4984(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-249.
      Strain: TN1379.

    Entry informationi

    Entry nameiAGP_SALTY
    AccessioniPrimary (citable) accession number: O33921
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: December 13, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3