ID CISY_RHIME Reviewed; 429 AA. AC O33915; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 30-MAY-2000, sequence version 2. DT 27-MAR-2024, entry version 127. DE RecName: Full=Citrate synthase; DE EC=2.3.3.16; GN Name=gltA; OrderedLocusNames=R01509; ORFNames=SMc02087; OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium OS meliloti). OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales; OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium. OX NCBI_TaxID=266834; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=104A14; RA Mortimer M.W., McDermott T.R., Kahn M.L.; RT "Isolation and characterization of a gene coding for citrate synthase from RT Rhizobium meliloti."; RL Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1021; RX PubMed=11481430; DOI=10.1073/pnas.161294398; RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T., RA Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., RA Thebault P., Vandenbol M., Weidner S., Galibert F.; RT "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium RT meliloti strain 1021."; RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1021; RX PubMed=11474104; DOI=10.1126/science.1060966; RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F., RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G., RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P., RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S., RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I., RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S., RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C., RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R., RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H., RA Wong K., Yeh K.-C., Batut J.; RT "The composite genome of the legume symbiont Sinorhizobium meliloti."; RL Science 293:668-672(2001). CC -!- CATALYTIC ACTIVITY: CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+); CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:57288; EC=2.3.3.16; Evidence={ECO:0000255|PROSITE- CC ProRule:PRU10117}; CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate CC from oxaloacetate: step 1/2. CC -!- SIMILARITY: Belongs to the citrate synthase family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U75365; AAB82405.1; -; Genomic_DNA. DR EMBL; AL591688; CAC46088.1; -; Genomic_DNA. DR RefSeq; NP_385615.1; NC_003047.1. DR RefSeq; WP_010969265.1; NC_003047.1. DR AlphaFoldDB; O33915; -. DR SMR; O33915; -. DR EnsemblBacteria; CAC46088; CAC46088; SMc02087. DR GeneID; 61602972; -. DR KEGG; sme:SMc02087; -. DR PATRIC; fig|266834.11.peg.2930; -. DR eggNOG; COG0372; Bacteria. DR HOGENOM; CLU_025068_0_0_5; -. DR OrthoDB; 9800864at2; -. DR UniPathway; UPA00223; UER00717. DR Proteomes; UP000001976; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro. DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. DR CDD; cd06114; EcCS_like; 1. DR Gene3D; 2.20.28.60; -; 1. DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1. DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1. DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub. DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub. DR InterPro; IPR002020; Citrate_synthase. DR InterPro; IPR019810; Citrate_synthase_AS. DR InterPro; IPR024176; Citrate_synthase_bac-typ. DR InterPro; IPR036969; Citrate_synthase_sf. DR InterPro; IPR010953; Citrate_synthase_typ-I. DR NCBIfam; TIGR01798; cit_synth_I; 1. DR PANTHER; PTHR42871; CITRATE SYNTHASE; 1. DR PANTHER; PTHR42871:SF1; CITRATE SYNTHASE; 1. DR Pfam; PF00285; Citrate_synt; 1. DR PIRSF; PIRSF001369; Citrate_synth; 1. DR PRINTS; PR00143; CITRTSNTHASE. DR SUPFAM; SSF48256; Citrate synthase; 1. DR PROSITE; PS00480; CITRATE_SYNTHASE; 1. PE 3: Inferred from homology; KW Reference proteome; Transferase; Tricarboxylic acid cycle. FT CHAIN 1..429 FT /note="Citrate synthase" FT /id="PRO_0000169953" FT ACT_SITE 306 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10117" FT ACT_SITE 364 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10117" FT CONFLICT 209 FT /note="E -> D (in Ref. 1; AAB82405)" FT /evidence="ECO:0000305" FT CONFLICT 229 FT /note="D -> N (in Ref. 1; AAB82405)" FT /evidence="ECO:0000305" FT CONFLICT 282 FT /note="V -> A (in Ref. 1; AAB82405)" FT /evidence="ECO:0000305" FT CONFLICT 290 FT /note="T -> A (in Ref. 1; AAB82405)" FT /evidence="ECO:0000305" FT CONFLICT 355 FT /note="I -> V (in Ref. 1; AAB82405)" FT /evidence="ECO:0000305" FT CONFLICT 427 FT /note="S -> T (in Ref. 1; AAB82405)" FT /evidence="ECO:0000305" SQ SEQUENCE 429 AA; 48002 MW; F28D1C61427974F8 CRC64; MSEKSATVTF GGKSADLPVR SGSIGPDVVD IGSLYKQTTM FTYDPGFTST ASCESKITYI DGDEGVLLHR GFPIEQLAEH GDFLEVCYLL LYGELPTKAQ KADFDYRVTH HTMVHEQMSR FFTGFRRDAH PMAVMCGCVG ALSAFYHDST DITDPHQRMV ASLRMIAKMP TIAAMAYKYH IGQPFVYPKN DLDYASNFLR MCFAVPCEEY VVNPVLARAM DRIFILHADH EQNASTSTVR LAGSSGANPF ACIAAGIACL WGPAHGGANE AALNMLAEIG TVDRIPEYIT KAKDKNDPFR LMGFGHRVYK NYDPRAKIMQ KTTHEVLAEL GHKDDPLLEV AMELERIALT DEYFIEKKLY PNIDFYSGIT LKALGFPTTM FTVLFALART VGWIAQWNEM IEDPEQRIGR PRQLYVGAPL RDYVPISKR //