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O33915

- CISY_RHIME

UniProt

O33915 - CISY_RHIME

Protein

Citrate synthase

Gene

gltA

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei306 – 3061PROSITE-ProRule annotation
    Active sitei364 – 3641PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-1984-MONOMER.
    RETL1328306-WGS:GSTH-5152-MONOMER.
    SMEL266834:GJF6-1544-MONOMER.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Gene namesi
    Name:gltA
    Ordered Locus Names:R01509
    ORF Names:SMc02087
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Citrate synthasePRO_0000169953Add
    BLAST

    Proteomic databases

    PRIDEiO33915.
    ProMEXiO33915.

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMc02087.

    Structurei

    3D structure databases

    ProteinModelPortaliO33915.
    SMRiO33915. Positions 5-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0372.
    HOGENOMiHOG000021224.
    KOiK01647.
    OMAiKETCDEV.
    OrthoDBiEOG6P8TP4.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O33915-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEKSATVTF GGKSADLPVR SGSIGPDVVD IGSLYKQTTM FTYDPGFTST    50
    ASCESKITYI DGDEGVLLHR GFPIEQLAEH GDFLEVCYLL LYGELPTKAQ 100
    KADFDYRVTH HTMVHEQMSR FFTGFRRDAH PMAVMCGCVG ALSAFYHDST 150
    DITDPHQRMV ASLRMIAKMP TIAAMAYKYH IGQPFVYPKN DLDYASNFLR 200
    MCFAVPCEEY VVNPVLARAM DRIFILHADH EQNASTSTVR LAGSSGANPF 250
    ACIAAGIACL WGPAHGGANE AALNMLAEIG TVDRIPEYIT KAKDKNDPFR 300
    LMGFGHRVYK NYDPRAKIMQ KTTHEVLAEL GHKDDPLLEV AMELERIALT 350
    DEYFIEKKLY PNIDFYSGIT LKALGFPTTM FTVLFALART VGWIAQWNEM 400
    IEDPEQRIGR PRQLYVGAPL RDYVPISKR 429
    Length:429
    Mass (Da):48,002
    Last modified:May 30, 2000 - v2
    Checksum:iF28D1C61427974F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti209 – 2091E → D in AAB82405. 1 PublicationCurated
    Sequence conflicti229 – 2291D → N in AAB82405. 1 PublicationCurated
    Sequence conflicti282 – 2821V → A in AAB82405. 1 PublicationCurated
    Sequence conflicti290 – 2901T → A in AAB82405. 1 PublicationCurated
    Sequence conflicti355 – 3551I → V in AAB82405. 1 PublicationCurated
    Sequence conflicti427 – 4271S → T in AAB82405. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U75365 Genomic DNA. Translation: AAB82405.1.
    AL591688 Genomic DNA. Translation: CAC46088.1.
    RefSeqiNP_385615.1. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC46088; CAC46088; SMc02087.
    GeneIDi1233162.
    KEGGisme:SMc02087.
    PATRICi23632357. VBISinMel96828_2930.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U75365 Genomic DNA. Translation: AAB82405.1 .
    AL591688 Genomic DNA. Translation: CAC46088.1 .
    RefSeqi NP_385615.1. NC_003047.1.

    3D structure databases

    ProteinModelPortali O33915.
    SMRi O33915. Positions 5-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc02087.

    Proteomic databases

    PRIDEi O33915.
    ProMEXi O33915.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC46088 ; CAC46088 ; SMc02087 .
    GeneIDi 1233162.
    KEGGi sme:SMc02087.
    PATRICi 23632357. VBISinMel96828_2930.

    Phylogenomic databases

    eggNOGi COG0372.
    HOGENOMi HOG000021224.
    KOi K01647.
    OMAi KETCDEV.
    OrthoDBi EOG6P8TP4.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci RETL1328306-WGS:GSTH-1984-MONOMER.
    RETL1328306-WGS:GSTH-5152-MONOMER.
    SMEL266834:GJF6-1544-MONOMER.

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a gene coding for citrate synthase from Rhizobium meliloti."
      Mortimer M.W., McDermott T.R., Kahn M.L.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 104A14.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiCISY_RHIME
    AccessioniPrimary (citable) accession number: O33915
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3