Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O33915 (CISY_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.16
Gene names
Name:gltA
Ordered Locus Names:R01509
ORF Names:SMc02087
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Citrate synthase
PRO_0000169953

Sites

Active site3061 By similarity
Active site3641 By similarity

Experimental info

Sequence conflict2091E → D in AAB82405. Ref.1
Sequence conflict2291D → N in AAB82405. Ref.1
Sequence conflict2821V → A in AAB82405. Ref.1
Sequence conflict2901T → A in AAB82405. Ref.1
Sequence conflict3551I → V in AAB82405. Ref.1
Sequence conflict4271S → T in AAB82405. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O33915 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: F28D1C61427974F8

FASTA42948,002
        10         20         30         40         50         60 
MSEKSATVTF GGKSADLPVR SGSIGPDVVD IGSLYKQTTM FTYDPGFTST ASCESKITYI 

        70         80         90        100        110        120 
DGDEGVLLHR GFPIEQLAEH GDFLEVCYLL LYGELPTKAQ KADFDYRVTH HTMVHEQMSR 

       130        140        150        160        170        180 
FFTGFRRDAH PMAVMCGCVG ALSAFYHDST DITDPHQRMV ASLRMIAKMP TIAAMAYKYH 

       190        200        210        220        230        240 
IGQPFVYPKN DLDYASNFLR MCFAVPCEEY VVNPVLARAM DRIFILHADH EQNASTSTVR 

       250        260        270        280        290        300 
LAGSSGANPF ACIAAGIACL WGPAHGGANE AALNMLAEIG TVDRIPEYIT KAKDKNDPFR 

       310        320        330        340        350        360 
LMGFGHRVYK NYDPRAKIMQ KTTHEVLAEL GHKDDPLLEV AMELERIALT DEYFIEKKLY 

       370        380        390        400        410        420 
PNIDFYSGIT LKALGFPTTM FTVLFALART VGWIAQWNEM IEDPEQRIGR PRQLYVGAPL 


RDYVPISKR 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a gene coding for citrate synthase from Rhizobium meliloti."
Mortimer M.W., McDermott T.R., Kahn M.L.
Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 104A14.
[2]"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021."
Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. expand/collapse author list , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.
Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.
[3]"The composite genome of the legume symbiont Sinorhizobium meliloti."
Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F., Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G., Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P., Cowie A. expand/collapse author list , Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S., Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I., Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S., Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C., Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R., Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H., Wong K., Yeh K.-C., Batut J.
Science 293:668-672(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U75365 Genomic DNA. Translation: AAB82405.1.
AL591688 Genomic DNA. Translation: CAC46088.1.
RefSeqNP_385615.1. NC_003047.1.

3D structure databases

ProteinModelPortalO33915.
SMRO33915. Positions 5-429.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc02087.

Proteomic databases

PRIDEO33915.
ProMEXO33915.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC46088; CAC46088; SMc02087.
GeneID1233162.
KEGGsme:SMc02087.
PATRIC23632357. VBISinMel96828_2930.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000021224.
KOK01647.
OMAKETCDEV.
OrthoDBEOG6P8TP4.

Enzyme and pathway databases

BioCycRETL1328306-WGS:GSTH-1984-MONOMER.
RETL1328306-WGS:GSTH-5152-MONOMER.
SMEL266834:GJF6-1544-MONOMER.
UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_RHIME
AccessionPrimary (citable) accession number: O33915
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways