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O33844

- DMA_TREPA

UniProt

O33844 - DMA_TREPA

Protein

DNA adenine methylase

Gene

dam

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Methylates DNA within the sequence GATC. Directly involved in methyl-directed DNA mismatch repair, DNA replication, and gene expression.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei13 – 131S-adenosyl-L-methionineBy similarity
    Binding sitei17 – 171S-adenosyl-L-methionine; via amide nitrogenBy similarity
    Binding sitei64 – 641S-adenosyl-L-methionineBy similarity
    Binding sitei212 – 2121S-adenosyl-L-methionineBy similarity

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciTPAL243276:GC1H-858-MONOMER.

    Protein family/group databases

    REBASEi3131. M.TpaI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA adenine methylase (EC:2.1.1.72)
    Alternative name(s):
    DNA adenine methyltransferase
    Deoxyadenosyl-methyltransferase
    M.TpaI
    Gene namesi
    Name:dam
    Ordered Locus Names:TP_0810
    OrganismiTreponema pallidum (strain Nichols)
    Taxonomic identifieri243276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000000811: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303DNA adenine methylasePRO_0000087998Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiO33844. 1 interaction.
    STRINGi243276.TP0810.

    Structurei

    3D structure databases

    ProteinModelPortaliO33844.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0338.
    KOiK06223.
    OMAiNSDSEFI.
    OrthoDBiEOG6CS08V.

    Family and domain databases

    Gene3Di1.10.1020.10. 1 hit.
    3.40.50.150. 2 hits.
    InterProiIPR023095. Ade_MeTrfase_dom_2.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR012263. M_m6A_EcoRV.
    IPR012327. MeTrfase_D12.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF02086. MethyltransfD12. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
    PRINTSiPR00505. D12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00571. dam. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O33844-1 [UniParc]FASTAAdd to Basket

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    MSRSDTARPF VKWAGGKRAL APTLFAHMPQ TFGSYFEPFV GGGALFWHLC    50
    ACTRVRLHDI YLSDINWPLL CAYAAVRDRV EELIVRVGQH IACHTPTYYR 100
    LARRKFAVCE HPLEVAALFL YLNRSCYNGL YRVNKAGQFN VPLGRAAPAS 150
    PFLNTTAPTP RSTQPAAQVG HLAIRIDEEN LRSCARALAN TTLNCQHFSC 200
    IQPARGDFVY LDPPYLGTFS AYDKTGFDRA AHESLAAFCM HLDARGVLFM 250
    LSNSDCPEVR AWYRPFRVQQ LNAPRCIARS AHARGKRCEV LITNYPCADT 300
    ATP 303
    Length:303
    Mass (Da):33,919
    Last modified:January 1, 1998 - v1
    Checksum:i62D2155EAE22DB90
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006263 Genomic DNA. Translation: AAB82782.1.
    AE000520 Genomic DNA. Translation: AAC65779.1.
    PIRiH71277.
    RefSeqiNP_219247.1. NC_000919.1.
    WP_010882255.1. NC_021490.2.
    YP_008091637.1. NC_021490.2.

    Genome annotation databases

    EnsemblBacteriaiAAC65779; AAC65779; TP_0810.
    GeneIDi15852101.
    2610874.
    KEGGitpa:TP0810.
    tpw:TPANIC_0810.
    PATRICi20531719. VBITrePal57110_0857.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006263 Genomic DNA. Translation: AAB82782.1 .
    AE000520 Genomic DNA. Translation: AAC65779.1 .
    PIRi H71277.
    RefSeqi NP_219247.1. NC_000919.1.
    WP_010882255.1. NC_021490.2.
    YP_008091637.1. NC_021490.2.

    3D structure databases

    ProteinModelPortali O33844.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O33844. 1 interaction.
    STRINGi 243276.TP0810.

    Protein family/group databases

    REBASEi 3131. M.TpaI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC65779 ; AAC65779 ; TP_0810 .
    GeneIDi 15852101.
    2610874.
    KEGGi tpa:TP0810.
    tpw:TPANIC_0810.
    PATRICi 20531719. VBITrePal57110_0857.

    Phylogenomic databases

    eggNOGi COG0338.
    KOi K06223.
    OMAi NSDSEFI.
    OrthoDBi EOG6CS08V.

    Enzyme and pathway databases

    BioCyci TPAL243276:GC1H-858-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1020.10. 1 hit.
    3.40.50.150. 2 hits.
    InterProi IPR023095. Ade_MeTrfase_dom_2.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR012263. M_m6A_EcoRV.
    IPR012327. MeTrfase_D12.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF02086. MethyltransfD12. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000398. M_m6A_EcoRV. 1 hit.
    PRINTSi PR00505. D12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00571. dam. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a Treponema pallidum subsp. pallidum gene encoding a DNA adenine methyltransferase."
      Stamm L.V., Greene S.R., Barnes N.Y., Bergen H.L., Hardham J.M.
      FEMS Microbiol. Lett. 155:115-119(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Nichols.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nichols.

    Entry informationi

    Entry nameiDMA_TREPA
    AccessioniPrimary (citable) accession number: O33844
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3