O33836 (GAL7_THEMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-1-phosphate uridylyltransferase
Short name=Gal-1-P uridylyltransferase
EC=2.7.7.12

Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:	galT
Ordered Locus Names:	TM_1191

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose.
Cofactor	Binds 1 zinc ion per subunit Potential.
Pathway	Carbohydrate metabolism; galactose metabolism.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Ligand	Iron Metal-binding Zinc
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Galactose-1-phosphate uridylyltransferase		PRO_0000169898
Sites
	Active site	143	1	Tele-UMP-histidine intermediate By similarity
	Metal binding	32	1	Zinc Potential
	Metal binding	35	1	Zinc Potential
	Metal binding	90	1	Zinc Potential
	Metal binding	141	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	O33836 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: E913778A6D770C6E	FASTA	318	37,633
	10 20 30 40 50 60 MMELRYNPLT DEWVIVSAAT QKRPVQPSKT ECPICVGGLE LPEEYDLVTF ENRYPSLKKD 70 80 90 100 110 120 PPPVNWKEKG PFRKEESRGV CEVVVYTSDH NTALPGMPLK QIEKLVEMWV DRTRDLSQHD 130 140 150 160 170 180 FVKYIFIFEN RGKEVGASLP HPHGQIYAFP FLPKRIEVKI GAMRKWYEEK RKCPICEVLE 190 200 210 220 230 240 SEGEERKVYE TEHFLALVPF YARFPYEVHI YPKRHVSTLL EFSKEEKKEF AKVLKVVTAK 250 260 270 280 290 300 YDKLFDQEFP YMMMFFQAPF NEEDVSHFFH FHVEFNPPKR DRDKLKWMAS VETGTWAFIN 310 PVVPEEAARQ LRETEVEI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Properties of an alpha-galactosidase, and structure of its gene galA, within an alpha- and beta-galactoside utilization gene cluster of the hyperthermophilic bacterium Thermotoga maritima." Liebl W., Wagner B., Schellhase J. Syst. Appl. Microbiol. 21:1-11(1998) [PubMed: 9741105] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ001072 Genomic DNA. Translation: CAA04515.1. AE000512 Genomic DNA. Translation: AAD36266.1.
PIR	D72283.
RefSeq	NP_228996.1. NC_000853.1.
3D structure databases
ProteinModelPortal	O33836.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	898293.
GenomeReviews	Gene locus TM_1191 in contig AE000512_GR.
KEGG	tma:TM1191.
NMPDR	fig|243274.1.peg.1180.
PATRIC	23937324. VBITheMar51294_1209.
TIGR	TM_1191.
Phylogenomic databases
HOGENOM	HBG600409.
OMA	WDHWQLH.
PhylomeDB	O33836.
ProtClustDB	CLSK875626.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-506. TMAR243274:TM_1191-MONOMER.
Family and domain databases
InterPro	IPR001937. GalP_UDPtransf1. IPR019779. GalP_UDPtransf1_His-AS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. IPR011146. His_triad-like_motif. IPR011151. His_triad_motif. [Graphical view]
Gene3D	G3DSA:3.30.428.10. His_triad_motif. 2 hits.
KO	K00965.
PANTHER	PTHR11943. GalP_UDPtransf1. 1 hit.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000808. GalT. 1 hit.
SUPFAM	SSF54197. His_triad-like_motif. 2 hits.
TIGRFAMs	TIGR00209. GalT_1. 1 hit.
PROSITE	PS00117. GAL_P_UDP_TRANSF_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL7_THEMA

Accession

Primary (citable) accession number: O33836

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program