##gff-version 3
O33807	UniProtKB	Signal peptide	1	28	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O33807	UniProtKB	Chain	29	291	.	.	.	ID=PRO_0000016991;Note=Beta-lactamase CTX-M-4	
O33807	UniProtKB	Active site	73	73	.	.	.	Note=Acyl-ester intermediate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10101	
O33807	UniProtKB	Binding site	237	239	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O33807	UniProtKB	Mutagenesis	240	240	.	.	.	Note=Causes minor alterations in the interaction of with beta-lactams%2C reduces slightly the relative hydrolytic activity against cefotaxime and the susceptibility to inhibition by clavulanate. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9593162;Dbxref=PMID:9593162	
O33807	UniProtKB	Mutagenesis	277	277	.	.	.	Note=Confers lower levels of resistance to cefotaxime%2C ceftriaxone and aztreonam while the levels of resistance to penicillins and penicillin-inhibitor combinations are similar. Slightly less susceptible to inhibition by clavulanate and tazobactam. Cause a 3-fold reduction in the relative rate of hydrolysis of cefotaxime. R->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9868772;Dbxref=PMID:9868772