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O33775

- HISX_SULSO

UniProt

O33775 - HISX_SULSO

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Protein
Histidinol dehydrogenase
Gene
hisD, SSO0599, C08_051
Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141NAD By similarity
Binding sitei176 – 1761NAD By similarity
Binding sitei199 – 1991NAD By similarity
Binding sitei222 – 2221Substrate By similarity
Metal bindingi244 – 2441Zinc By similarity
Binding sitei244 – 2441Substrate By similarity
Metal bindingi247 – 2471Zinc By similarity
Binding sitei247 – 2471Substrate By similarity
Active sitei298 – 2981Proton acceptor By similarity
Active sitei299 – 2991Proton acceptor By similarity
Binding sitei299 – 2991Substrate By similarity
Metal bindingi331 – 3311Zinc By similarity
Binding sitei331 – 3311Substrate By similarity
Binding sitei384 – 3841Substrate By similarity
Metal bindingi389 – 3891Zinc By similarity
Binding sitei389 – 3891Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-571-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:SSO0599
ORF Names:C08_051
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Histidinol dehydrogenaseUniRule annotation
PRO_0000135906Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0599.

Structurei

3D structure databases

ProteinModelPortaliO33775.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiNAMSILL.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33775-1 [UniParc]FASTAAdd to Basket

« Hide

MISYSLPNER PNDFSRVIPV VKDIIESVKT KGDNALYELT EKLDKVKIDN    50
IKAREEELKT QASKLDPKVK QAIDTAYEQL KAFHEMLVPP NIGGGYQGIS 100
FGVIWRSIEK IGIYVPSGKY SYPSTLLMAG IPAKVAKVKE IYVASPPTQE 150
GTVNPALAYV AIKLGVNEVY KIGGAQAIAA LAFGTESVKK VYKIVGPGNV 200
YVQAAKYLVS SVVGIDGIEG PTELVIIADE TAKAEYVALD MKAQAEHGPD 250
TYIVLLSNDD ELIRRVEEKI KNDKKIYYII KTKNLDEAIE IANKIAPEHL 300
SLYVKDAYTL MDKIVNAGAI SLGNTPPAII DYVAGPNHIL PTNGWAKIRG 350
GITVYDFIKP TMYANVRDIN KQLLEASISL ANYEGFIIHG KSIGARYE 398
Length:398
Mass (Da):43,635
Last modified:January 1, 1998 - v1
Checksum:iB989B35227ED564B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82227 Genomic DNA. Translation: AAB63023.1.
Y18930 Genomic DNA. Translation: CAB57701.1.
AE006641 Genomic DNA. Translation: AAK40909.1.
PIRiF90206.
RefSeqiNP_342119.1. NC_002754.1.
WP_009991117.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40909; AAK40909; SSO0599.
GeneIDi1454876.
KEGGisso:SSO0599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82227 Genomic DNA. Translation: AAB63023.1 .
Y18930 Genomic DNA. Translation: CAB57701.1 .
AE006641 Genomic DNA. Translation: AAK40909.1 .
PIRi F90206.
RefSeqi NP_342119.1. NC_002754.1.
WP_009991117.1. NC_002754.1.

3D structure databases

ProteinModelPortali O33775.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273057.SSO0599.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK40909 ; AAK40909 ; SSO0599 .
GeneIDi 1454876.
KEGGi sso:SSO0599.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi NAMSILL.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SSOL273057:GCH2-571-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary analysis of the hisCGABdFDEHI gene cluster from the archaeon Sulfolobus solfataricus P2."
    Charlebois R.L., Sensen C.W., Doolittle W.F., Brown J.R.
    J. Bacteriol. 179:4429-4432(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiHISX_SULSO
AccessioniPrimary (citable) accession number: O33775
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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