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O33775

- HISX_SULSO

UniProt

O33775 - HISX_SULSO

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei114 – 1141NADBy similarity
    Binding sitei176 – 1761NADBy similarity
    Binding sitei199 – 1991NADBy similarity
    Binding sitei222 – 2221SubstrateBy similarity
    Metal bindingi244 – 2441ZincBy similarity
    Binding sitei244 – 2441SubstrateBy similarity
    Metal bindingi247 – 2471ZincBy similarity
    Binding sitei247 – 2471SubstrateBy similarity
    Active sitei298 – 2981Proton acceptorBy similarity
    Active sitei299 – 2991Proton acceptorBy similarity
    Binding sitei299 – 2991SubstrateBy similarity
    Metal bindingi331 – 3311ZincBy similarity
    Binding sitei331 – 3311SubstrateBy similarity
    Binding sitei384 – 3841SubstrateBy similarity
    Metal bindingi389 – 3891ZincBy similarity
    Binding sitei389 – 3891SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-571-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    Ordered Locus Names:SSO0599
    ORF Names:C08_051
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Histidinol dehydrogenasePRO_0000135906Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273057.SSO0599.

    Structurei

    3D structure databases

    ProteinModelPortaliO33775.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiNAMSILL.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O33775-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISYSLPNER PNDFSRVIPV VKDIIESVKT KGDNALYELT EKLDKVKIDN    50
    IKAREEELKT QASKLDPKVK QAIDTAYEQL KAFHEMLVPP NIGGGYQGIS 100
    FGVIWRSIEK IGIYVPSGKY SYPSTLLMAG IPAKVAKVKE IYVASPPTQE 150
    GTVNPALAYV AIKLGVNEVY KIGGAQAIAA LAFGTESVKK VYKIVGPGNV 200
    YVQAAKYLVS SVVGIDGIEG PTELVIIADE TAKAEYVALD MKAQAEHGPD 250
    TYIVLLSNDD ELIRRVEEKI KNDKKIYYII KTKNLDEAIE IANKIAPEHL 300
    SLYVKDAYTL MDKIVNAGAI SLGNTPPAII DYVAGPNHIL PTNGWAKIRG 350
    GITVYDFIKP TMYANVRDIN KQLLEASISL ANYEGFIIHG KSIGARYE 398
    Length:398
    Mass (Da):43,635
    Last modified:January 1, 1998 - v1
    Checksum:iB989B35227ED564B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82227 Genomic DNA. Translation: AAB63023.1.
    Y18930 Genomic DNA. Translation: CAB57701.1.
    AE006641 Genomic DNA. Translation: AAK40909.1.
    PIRiF90206.
    RefSeqiNP_342119.1. NC_002754.1.
    WP_009991117.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK40909; AAK40909; SSO0599.
    GeneIDi1454876.
    KEGGisso:SSO0599.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82227 Genomic DNA. Translation: AAB63023.1 .
    Y18930 Genomic DNA. Translation: CAB57701.1 .
    AE006641 Genomic DNA. Translation: AAK40909.1 .
    PIRi F90206.
    RefSeqi NP_342119.1. NC_002754.1.
    WP_009991117.1. NC_002754.1.

    3D structure databases

    ProteinModelPortali O33775.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273057.SSO0599.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK40909 ; AAK40909 ; SSO0599 .
    GeneIDi 1454876.
    KEGGi sso:SSO0599.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi NAMSILL.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci SSOL273057:GCH2-571-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary analysis of the hisCGABdFDEHI gene cluster from the archaeon Sulfolobus solfataricus P2."
      Charlebois R.L., Sensen C.W., Doolittle W.F., Brown J.R.
      J. Bacteriol. 179:4429-4432(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

    Entry informationi

    Entry nameiHISX_SULSO
    AccessioniPrimary (citable) accession number: O33775
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3