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O33775 (HISX_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:SSO0599
ORF Names:C08_051
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135906

Sites

Active site2981Proton acceptor By similarity
Active site2991Proton acceptor By similarity
Metal binding2441Zinc By similarity
Metal binding2471Zinc By similarity
Metal binding3311Zinc By similarity
Metal binding3891Zinc By similarity
Binding site1141NAD By similarity
Binding site1761NAD By similarity
Binding site1991NAD By similarity
Binding site2221Substrate By similarity
Binding site2441Substrate By similarity
Binding site2471Substrate By similarity
Binding site2991Substrate By similarity
Binding site3311Substrate By similarity
Binding site3841Substrate By similarity
Binding site3891Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O33775 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: B989B35227ED564B

FASTA39843,635
        10         20         30         40         50         60 
MISYSLPNER PNDFSRVIPV VKDIIESVKT KGDNALYELT EKLDKVKIDN IKAREEELKT 

        70         80         90        100        110        120 
QASKLDPKVK QAIDTAYEQL KAFHEMLVPP NIGGGYQGIS FGVIWRSIEK IGIYVPSGKY 

       130        140        150        160        170        180 
SYPSTLLMAG IPAKVAKVKE IYVASPPTQE GTVNPALAYV AIKLGVNEVY KIGGAQAIAA 

       190        200        210        220        230        240 
LAFGTESVKK VYKIVGPGNV YVQAAKYLVS SVVGIDGIEG PTELVIIADE TAKAEYVALD 

       250        260        270        280        290        300 
MKAQAEHGPD TYIVLLSNDD ELIRRVEEKI KNDKKIYYII KTKNLDEAIE IANKIAPEHL 

       310        320        330        340        350        360 
SLYVKDAYTL MDKIVNAGAI SLGNTPPAII DYVAGPNHIL PTNGWAKIRG GITVYDFIKP 

       370        380        390 
TMYANVRDIN KQLLEASISL ANYEGFIIHG KSIGARYE 

« Hide

References

« Hide 'large scale' references
[1]"Evolutionary analysis of the hisCGABdFDEHI gene cluster from the archaeon Sulfolobus solfataricus P2."
Charlebois R.L., Sensen C.W., Doolittle W.F., Brown J.R.
J. Bacteriol. 179:4429-4432(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[2]"Gene content and organization of a 281-kbp contig from the genome of the extremely thermophilic archaeon, Sulfolobus solfataricus P2."
Charlebois R.L., Singh R.K., Chan-Weiher C.C.-Y., Allard G., Chow C., Confalonieri F., Curtis B., Duguet M., Erauso G., Faguy D., Gaasterland T., Garrett R.A., Gordon P., Jeffries A.C., Kozera C., Kushwaha N., Lafleur E., Medina N. expand/collapse author list , Peng X., Penny S.L., She Q., St Jean A., van der Oost J., Young F., Zivanovic Y., Doolittle W.F., Ragan M.A., Sensen C.W.
Genome 43:116-136(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[3]"The complete genome of the crenarchaeon Sulfolobus solfataricus P2."
She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. expand/collapse author list , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.
Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U82227 Genomic DNA. Translation: AAB63023.1.
Y18930 Genomic DNA. Translation: CAB57701.1.
AE006641 Genomic DNA. Translation: AAK40909.1.
PIRF90206.
RefSeqNP_342119.1. NC_002754.1.

3D structure databases

ProteinModelPortalO33775.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO0599.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK40909; AAK40909; SSO0599.
GeneID1454876.
KEGGsso:SSO0599.

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAPSEILII.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-571-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_SULSO
AccessionPrimary (citable) accession number: O33775
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways