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O33772

- HIS4_SULSO

UniProt

O33772 - HIS4_SULSO

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Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

hisA

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91Proton acceptorBy similarity
Active sitei129 – 1291Proton donorBy similarity

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-568-MONOMER.
UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene namesi
Name:hisA
Ordered Locus Names:SSO0594
ORF Names:C08_055
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2322321-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_0000142103Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0594.

Structurei

3D structure databases

ProteinModelPortaliO33772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.Curated

Phylogenomic databases

eggNOGiCOG0106.
HOGENOMiHOG000224614.
InParanoidiO33772.
KOiK01814.
OMAiYVCNEGT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01014. HisA.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

O33772-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEIIPSIDI SFGKAVKRIR GVRGTGLVLG NPIELANKLY NEGYSRIHVV
60 70 80 90 100
DLDAAEGVGN NEMYIKEICK IGFDWIQVGG GIRDVEKAKR LISLDVNALI
110 120 130 140 150
FSTIVFTNFN LFYNIVREIG NNRVIVSIDY DDTKRVLISG WKERSMEIID
160 170 180 190 200
GIKKVNELEL LGIILTYVTN EGTVKGIDYS VKDYAKLIRG VKEYAGGVSS
210 220 230
DSDITFLKNV GFDYIIVGMA FYLNKIRGTN VV
Length:232
Mass (Da):25,899
Last modified:January 1, 1998 - v1
Checksum:i4E8C4D1CC7549186
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82227 Genomic DNA. Translation: AAB63020.1.
Y18930 Genomic DNA. Translation: CAB57705.1.
AE006641 Genomic DNA. Translation: AAK40906.1.
PIRiC90206.
RefSeqiNP_342116.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40906; AAK40906; SSO0594.
GeneIDi1454873.
KEGGisso:SSO0594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82227 Genomic DNA. Translation: AAB63020.1 .
Y18930 Genomic DNA. Translation: CAB57705.1 .
AE006641 Genomic DNA. Translation: AAK40906.1 .
PIRi C90206.
RefSeqi NP_342116.1. NC_002754.1.

3D structure databases

ProteinModelPortali O33772.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273057.SSO0594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK40906 ; AAK40906 ; SSO0594 .
GeneIDi 1454873.
KEGGi sso:SSO0594.

Phylogenomic databases

eggNOGi COG0106.
HOGENOMi HOG000224614.
InParanoidi O33772.
KOi K01814.
OMAi YVCNEGT.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .
BioCyci SSOL273057:GCH2-568-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01014. HisA.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary analysis of the hisCGABdFDEHI gene cluster from the archaeon Sulfolobus solfataricus P2."
    Charlebois R.L., Sensen C.W., Doolittle W.F., Brown J.R.
    J. Bacteriol. 179:4429-4432(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiHIS4_SULSO
AccessioniPrimary (citable) accession number: O33772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3