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O33768

- SYL2_SULSO

UniProt

O33768 - SYL2_SULSO

Protein

Leucine--tRNA ligase 2

Gene

leuS2

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei626 – 6261ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-564-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligase 2UniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetase 2UniRule annotation
    Short name:
    LeuRS 2UniRule annotation
    Gene namesi
    Name:leuS2UniRule annotation
    Synonyms:leuS
    Ordered Locus Names:SSO0589
    ORF Names:C21_009
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 944944Leucine--tRNA ligase 2PRO_0000152145Add
    BLAST

    Proteomic databases

    PRIDEiO33768.

    Interactioni

    Protein-protein interaction databases

    STRINGi273057.SSO0589.

    Structurei

    3D structure databases

    ProteinModelPortaliO33768.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 4611"HIGH" regionAdd
    BLAST
    Motifi623 – 6275"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiIDKWLLH.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O33768-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNIAYKWQT RWEEDKIYES NPNPSKPKFF TTVAFPYPNS PWHIGHGRTY    50
    VTGDILARYK RMRGYNVLFP MAFHYTGTPI MAMADAIAKG DKELIETFKD 100
    IYEISPDVIP RMSDPLFMAN YFKEDIKASM REIGLGIDWR REFTTIDPEF 150
    SSFVTWQFHK LQSKGYIVKD THPVGWCPVH HIPVGMHDTK GDVEPEIGEF 200
    VLIYFNSEKG IFPAATLRPE TIFGATALWI NPSEMYVVAS MLGKKMILSE 250
    KAAAKLSFQI DDIEIEEKIK GSKLVGLKVE NPITGKHIAV LGADFVDVSL 300
    GTGVVMSVPA HAPFDYYYSK KTFKNNNIEI IPVITVEGLG NALAKDVVEK 350
    NNPKSDEDLK KLTEYVYRTE YNKGVLRSDL GNLIREEYRN ELKSLGGLPV 400
    PKGRELITNF LISKGLGRKI FEVMNKPVYC RCGTEIVVKI LKDQWFLDYS 450
    NKEWKELARK SLSKINVIPE ESRKDFEFTI EWLEKRACAR TRGLGTPLPW 500
    DKKWIIESLS DSTIYMAYYT ISHKIKQYKL SPSKLTQEFW DYVMLGIGNL 550
    EEISEKTGIP SNIIKEFREE FLYWYPLDIR HSGKDLIPNH LTFFIFNHAA 600
    IFQENLWPKA IAVNGLVLYE GKKMSKSLRN IIPLRKGLKM YGVDVMRIAV 650
    SSTADMGSDV NFSESLVKTV GETLRKMYEL FKSLDNYTGD ILGFPEKWLL 700
    SRIYEITSST TRHMEALELR DAVNELLFVF SSDLDEYFGM VSAEGREANN 750
    KVLREVLTIW LKLITPFAPH LAEEIWHEIL KQKTYIVNEG WPEVEGSKMD 800
    ELTLLEHEYM KRIVEDIRSI LNIFKGTPKL IKIYALNDSR YMELLRDAIV 850
    ANGQMKKFMD IHKPKSREDA RILQKIFNES LEIDDKMKKL VTNYNINEVD 900
    VLNKLSKYIR RKLNVDILIE PYDEEVKKTY NKEAMPLRPA IIIE 944
    Length:944
    Mass (Da):109,104
    Last modified:June 20, 2001 - v2
    Checksum:i9ACAFCFBF04160DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18930 Genomic DNA. Translation: CAB57710.1.
    AE006641 Genomic DNA. Translation: AAK40902.1.
    U82227 Genomic DNA. Translation: AAB63016.1.
    PIRiG90205.
    RefSeqiNP_342112.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK40902; AAK40902; SSO0589.
    GeneIDi1454869.
    KEGGisso:SSO0589.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18930 Genomic DNA. Translation: CAB57710.1 .
    AE006641 Genomic DNA. Translation: AAK40902.1 .
    U82227 Genomic DNA. Translation: AAB63016.1 .
    PIRi G90205.
    RefSeqi NP_342112.1. NC_002754.1.

    3D structure databases

    ProteinModelPortali O33768.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273057.SSO0589.

    Proteomic databases

    PRIDEi O33768.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK40902 ; AAK40902 ; SSO0589 .
    GeneIDi 1454869.
    KEGGi sso:SSO0589.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi IDKWLLH.

    Enzyme and pathway databases

    BioCyci SSOL273057:GCH2-564-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
    3. "Evolutionary analysis of the hisCGABdFDEHI gene cluster from the archaeon Sulfolobus solfataricus P2."
      Charlebois R.L., Sensen C.W., Doolittle W.F., Brown J.R.
      J. Bacteriol. 179:4429-4432(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 762-944.
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

    Entry informationi

    Entry nameiSYL2_SULSO
    AccessioniPrimary (citable) accession number: O33768
    Secondary accession number(s): Q9UWZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3