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O33768

- SYL2_SULSO

UniProt

O33768 - SYL2_SULSO

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Protein

Leucine--tRNA ligase 2

Gene

leuS2

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei626 – 6261ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-564-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 2UniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetase 2UniRule annotation
Short name:
LeuRS 2UniRule annotation
Gene namesi
Name:leuS2UniRule annotation
Synonyms:leuS
Ordered Locus Names:SSO0589
ORF Names:C21_009
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 944944Leucine--tRNA ligase 2PRO_0000152145Add
BLAST

Proteomic databases

PRIDEiO33768.

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0589.

Structurei

3D structure databases

ProteinModelPortaliO33768.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionAdd
BLAST
Motifi623 – 6275"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
InParanoidiO33768.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

O33768 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNIAYKWQT RWEEDKIYES NPNPSKPKFF TTVAFPYPNS PWHIGHGRTY
60 70 80 90 100
VTGDILARYK RMRGYNVLFP MAFHYTGTPI MAMADAIAKG DKELIETFKD
110 120 130 140 150
IYEISPDVIP RMSDPLFMAN YFKEDIKASM REIGLGIDWR REFTTIDPEF
160 170 180 190 200
SSFVTWQFHK LQSKGYIVKD THPVGWCPVH HIPVGMHDTK GDVEPEIGEF
210 220 230 240 250
VLIYFNSEKG IFPAATLRPE TIFGATALWI NPSEMYVVAS MLGKKMILSE
260 270 280 290 300
KAAAKLSFQI DDIEIEEKIK GSKLVGLKVE NPITGKHIAV LGADFVDVSL
310 320 330 340 350
GTGVVMSVPA HAPFDYYYSK KTFKNNNIEI IPVITVEGLG NALAKDVVEK
360 370 380 390 400
NNPKSDEDLK KLTEYVYRTE YNKGVLRSDL GNLIREEYRN ELKSLGGLPV
410 420 430 440 450
PKGRELITNF LISKGLGRKI FEVMNKPVYC RCGTEIVVKI LKDQWFLDYS
460 470 480 490 500
NKEWKELARK SLSKINVIPE ESRKDFEFTI EWLEKRACAR TRGLGTPLPW
510 520 530 540 550
DKKWIIESLS DSTIYMAYYT ISHKIKQYKL SPSKLTQEFW DYVMLGIGNL
560 570 580 590 600
EEISEKTGIP SNIIKEFREE FLYWYPLDIR HSGKDLIPNH LTFFIFNHAA
610 620 630 640 650
IFQENLWPKA IAVNGLVLYE GKKMSKSLRN IIPLRKGLKM YGVDVMRIAV
660 670 680 690 700
SSTADMGSDV NFSESLVKTV GETLRKMYEL FKSLDNYTGD ILGFPEKWLL
710 720 730 740 750
SRIYEITSST TRHMEALELR DAVNELLFVF SSDLDEYFGM VSAEGREANN
760 770 780 790 800
KVLREVLTIW LKLITPFAPH LAEEIWHEIL KQKTYIVNEG WPEVEGSKMD
810 820 830 840 850
ELTLLEHEYM KRIVEDIRSI LNIFKGTPKL IKIYALNDSR YMELLRDAIV
860 870 880 890 900
ANGQMKKFMD IHKPKSREDA RILQKIFNES LEIDDKMKKL VTNYNINEVD
910 920 930 940
VLNKLSKYIR RKLNVDILIE PYDEEVKKTY NKEAMPLRPA IIIE
Length:944
Mass (Da):109,104
Last modified:June 20, 2001 - v2
Checksum:i9ACAFCFBF04160DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y18930 Genomic DNA. Translation: CAB57710.1.
AE006641 Genomic DNA. Translation: AAK40902.1.
U82227 Genomic DNA. Translation: AAB63016.1.
PIRiG90205.
RefSeqiNP_342112.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40902; AAK40902; SSO0589.
GeneIDi1454869.
KEGGisso:SSO0589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y18930 Genomic DNA. Translation: CAB57710.1 .
AE006641 Genomic DNA. Translation: AAK40902.1 .
U82227 Genomic DNA. Translation: AAB63016.1 .
PIRi G90205.
RefSeqi NP_342112.1. NC_002754.1.

3D structure databases

ProteinModelPortali O33768.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273057.SSO0589.

Proteomic databases

PRIDEi O33768.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK40902 ; AAK40902 ; SSO0589 .
GeneIDi 1454869.
KEGGi sso:SSO0589.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
InParanoidi O33768.
KOi K01869.
OMAi IDKWLLH.

Enzyme and pathway databases

BioCyci SSOL273057:GCH2-564-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  3. "Evolutionary analysis of the hisCGABdFDEHI gene cluster from the archaeon Sulfolobus solfataricus P2."
    Charlebois R.L., Sensen C.W., Doolittle W.F., Brown J.R.
    J. Bacteriol. 179:4429-4432(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 762-944.
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiSYL2_SULSO
AccessioniPrimary (citable) accession number: O33768
Secondary accession number(s): Q9UWZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 20, 2001
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3