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Protein

Leucine--tRNA ligase 2

Gene

leuS2

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei626ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 2UniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetase 2UniRule annotation
Short name:
LeuRS 2UniRule annotation
Gene namesi
Name:leuS2UniRule annotation
Synonyms:leuS
Ordered Locus Names:SSO0589
ORF Names:C21_009
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521451 – 944Leucine--tRNA ligase 2Add BLAST944

Proteomic databases

PRIDEiO33768

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0589

Structurei

3D structure databases

ProteinModelPortaliO33768
SMRiO33768
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 46"HIGH" regionAdd BLAST11
Motifi623 – 627"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
InParanoidiO33768
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit

Sequencei

Sequence statusi: Complete.

O33768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNIAYKWQT RWEEDKIYES NPNPSKPKFF TTVAFPYPNS PWHIGHGRTY
60 70 80 90 100
VTGDILARYK RMRGYNVLFP MAFHYTGTPI MAMADAIAKG DKELIETFKD
110 120 130 140 150
IYEISPDVIP RMSDPLFMAN YFKEDIKASM REIGLGIDWR REFTTIDPEF
160 170 180 190 200
SSFVTWQFHK LQSKGYIVKD THPVGWCPVH HIPVGMHDTK GDVEPEIGEF
210 220 230 240 250
VLIYFNSEKG IFPAATLRPE TIFGATALWI NPSEMYVVAS MLGKKMILSE
260 270 280 290 300
KAAAKLSFQI DDIEIEEKIK GSKLVGLKVE NPITGKHIAV LGADFVDVSL
310 320 330 340 350
GTGVVMSVPA HAPFDYYYSK KTFKNNNIEI IPVITVEGLG NALAKDVVEK
360 370 380 390 400
NNPKSDEDLK KLTEYVYRTE YNKGVLRSDL GNLIREEYRN ELKSLGGLPV
410 420 430 440 450
PKGRELITNF LISKGLGRKI FEVMNKPVYC RCGTEIVVKI LKDQWFLDYS
460 470 480 490 500
NKEWKELARK SLSKINVIPE ESRKDFEFTI EWLEKRACAR TRGLGTPLPW
510 520 530 540 550
DKKWIIESLS DSTIYMAYYT ISHKIKQYKL SPSKLTQEFW DYVMLGIGNL
560 570 580 590 600
EEISEKTGIP SNIIKEFREE FLYWYPLDIR HSGKDLIPNH LTFFIFNHAA
610 620 630 640 650
IFQENLWPKA IAVNGLVLYE GKKMSKSLRN IIPLRKGLKM YGVDVMRIAV
660 670 680 690 700
SSTADMGSDV NFSESLVKTV GETLRKMYEL FKSLDNYTGD ILGFPEKWLL
710 720 730 740 750
SRIYEITSST TRHMEALELR DAVNELLFVF SSDLDEYFGM VSAEGREANN
760 770 780 790 800
KVLREVLTIW LKLITPFAPH LAEEIWHEIL KQKTYIVNEG WPEVEGSKMD
810 820 830 840 850
ELTLLEHEYM KRIVEDIRSI LNIFKGTPKL IKIYALNDSR YMELLRDAIV
860 870 880 890 900
ANGQMKKFMD IHKPKSREDA RILQKIFNES LEIDDKMKKL VTNYNINEVD
910 920 930 940
VLNKLSKYIR RKLNVDILIE PYDEEVKKTY NKEAMPLRPA IIIE
Length:944
Mass (Da):109,104
Last modified:June 20, 2001 - v2
Checksum:i9ACAFCFBF04160DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA Translation: CAB57710.1
AE006641 Genomic DNA Translation: AAK40902.1
U82227 Genomic DNA Translation: AAB63016.1
PIRiG90205
RefSeqiWP_009991108.1, NC_002754.1

Genome annotation databases

EnsemblBacteriaiAAK40902; AAK40902; SSO0589
GeneIDi27426894
KEGGisso:SSO0589
PATRICifig|273057.12.peg.598

Similar proteinsi

Entry informationi

Entry nameiSYL2_SULSO
AccessioniPrimary (citable) accession number: O33768
Secondary accession number(s): Q9UWZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 20, 2001
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health