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Protein

RNA polymerase sigma factor SigA

Gene

sigA

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi331 – 350H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Sigma factor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciSMUT210007:G1FZX-788-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor SigAUniRule annotation
Alternative name(s):
Sigma-42
Gene namesi
Name:sigAUniRule annotation
Synonyms:rpoD
Ordered Locus Names:SMU_822
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000939241 – 371RNA polymerase sigma factor SigAAdd BLAST371

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.UniRule annotation

Protein-protein interaction databases

STRINGi210007.SMU_822

Structurei

3D structure databases

ProteinModelPortaliO33662
SMRiO33662
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 207Sigma-70 factor domain-2UniRule annotationAdd BLAST71
Regioni216 – 292Sigma-70 factor domain-3UniRule annotationAdd BLAST77
Regioni305 – 358Sigma-70 factor domain-4UniRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi161 – 164Interaction with polymerase core subunit RpoC4

Sequence similaritiesi

Belongs to the sigma-70 factor family. RpoD/SigA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DG1 Bacteria
COG0568 LUCA
KOiK03086
OMAiYQRWLAE
PhylomeDBiO33662

Family and domain databases

Gene3Di1.10.10.10, 2 hits
HAMAPiMF_00963 Sigma70_RpoD_SigA, 1 hit
InterProiView protein in InterPro
IPR014284 RNA_pol_sigma-70_dom
IPR000943 RNA_pol_sigma70
IPR009042 RNA_pol_sigma70_r1_2
IPR007627 RNA_pol_sigma70_r2
IPR007624 RNA_pol_sigma70_r3
IPR007630 RNA_pol_sigma70_r4
IPR007127 RNA_pol_sigma_70_r1_1
IPR013325 RNA_pol_sigma_r2
IPR013324 RNA_pol_sigma_r3/r4-like
IPR012760 RNA_pol_sigma_RpoD_C
IPR028630 Sigma70_RpoD
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF03979 Sigma70_r1_1, 1 hit
PF00140 Sigma70_r1_2, 1 hit
PF04542 Sigma70_r2, 1 hit
PF04539 Sigma70_r3, 1 hit
PF04545 Sigma70_r4, 1 hit
PRINTSiPR00046 SIGMA70FCT
SUPFAMiSSF88659 SSF88659, 2 hits
SSF88946 SSF88946, 1 hit
TIGRFAMsiTIGR02393 RpoD_Cterm, 1 hit
TIGR02937 sigma70-ECF, 1 hit
PROSITEiView protein in PROSITE
PS00715 SIGMA70_1, 1 hit
PS00716 SIGMA70_2, 1 hit

Sequencei

Sequence statusi: Complete.

O33662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNNKKKTSS TFNVQVADFI RNHKKEGVAV DDEVTEKLVI PFELEAEQID
60 70 80 90 100
DLLERLTDGG ISITDREGNP STKYAVEEIK PEELTDEELL GSNSAKVNDP
110 120 130 140 150
VRMYLKEIGV VPLLTNEEEK ELAIAVENGD LEAKQRLAEA NLRLVVSIAK
160 170 180 190 200
RYVGRGMQFL DLIQEGNMGL MKAVDKFDYS KGFKFSTYAT WWIRQAITRA
210 220 230 240 250
IADQARTIRI PVHMVETINK LVREQRNLLQ ELGQDPTPEQ IAERMDMTPD
260 270 280 290 300
KVREILKIAQ EPVSLETPIG EEDDSHLGDF IEDEVIENPV DYTTRVVLRE
310 320 330 340 350
QLDEVLDTLT DREENVLRLR FGLDDGKMRT LEDVGKVFDV TRERIRQIEA
360 370
KALRKLRHPS RSKQLRDFVE D
Length:371
Mass (Da):42,547
Last modified:January 1, 1998 - v1
Checksum:i52DE0E30DAC35CB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000631 Genomic DNA Translation: BAA21507.1
AE014133 Genomic DNA Translation: AAN58538.1
RefSeqiNP_721232.1, NC_004350.2
WP_002261972.1, NC_004350.2

Genome annotation databases

EnsemblBacteriaiAAN58538; AAN58538; SMU_822
GeneIDi1028204
KEGGismu:SMU_822
PATRICifig|210007.7.peg.729

Entry informationi

Entry nameiSIGA_STRMU
AccessioniPrimary (citable) accession number: O33662
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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