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Protein

60 kDa chaperonin 1

Gene

groL1

Organism
Streptomyces lividans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin 1UniRule annotation
Alternative name(s):
Protein Cpn60 1UniRule annotation
groEL1 protein
Gene namesi
Name:groL1UniRule annotation
Synonyms:groEL1UniRule annotation
OrganismiStreptomyces lividans
Taxonomic identifieri1916 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000635532 – 54160 kDa chaperonin 1Add BLAST540

Proteomic databases

PRIDEiO33659.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO33659.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O33659-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKILKFDED ARRALERGVN KLADTVKVTI GPKANVVIDK KFGPPTITND
60 70 80 90 100
GVTIAREVEV EDPYENLGAQ LVKEVATKTN DIAGDGTTTA TVLAQALVRE
110 120 130 140 150
GLKNVAAGAS PALLKKGIDA AVAAVSEDLL ATARPIDEKS DIAAVAALSA
160 170 180 190 200
QDQQVGELIA EAMDKVGKDG VITVEESNTF GLELDFTEGM AFDKGYRLRL
210 220 230 240 250
LRTDQERMEA VLDDPYILIN QGKISSIADL LPLLEKVIQA NASKPLLIIA
260 270 280 290 300
EDLEGEALST LVVNQIRGTF NAVAVKAPGF GDRRKAMLQD MAVLTGATVI
310 320 330 340 350
SEEVGLKLDQ VGLEVLGTAR RITVTKDDTT IVDGPGKRDE VQARIAQIKA
360 370 380 390 400
EIENTDSDWD REKLQERLAK LAGGVCVIKV GAATEVELKE RKHRLEDAIS
410 420 430 440 450
ATRAAVEEGI VSGGGSALVH AVKVLEGNLG KTGDEATGVA VVRRAAVEPL
460 470 480 490 500
RWIAENPGLE GYVITSKVAD LDKGQGFNAA TGEYGDLVKA GVIDPVKVTR
510 520 530 540
SALENPASIA SLLLTTETLV VEKKEEEEPA AGGHSHLGHS H
Length:541
Mass (Da):57,309
Last modified:January 23, 2007 - v3
Checksum:i90A55824708EC826
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95970 Genomic DNA. Translation: CAA65225.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95970 Genomic DNA. Translation: CAA65225.1.

3D structure databases

ProteinModelPortaliO33659.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO33659.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH601_STRLI
AccessioniPrimary (citable) accession number: O33659
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.