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Protein

60 kDa chaperonin 2

Gene

groL2

Organism
Streptomyces lividans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin 2
Alternative name(s):
Protein Cpn60 2
groEL2 protein
Gene namesi
Name:groL2
Synonyms:groEL2
OrganismiStreptomyces lividans
Taxonomic identifieri1916 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 47747660 kDa chaperonin 2PRO_0000063554Add
BLAST

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.By similarity

Structurei

3D structure databases

ProteinModelPortaliO33658.
SMRiO33658. Positions 2-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O33658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIIAFDEK ARRGLEGGMN QLADAVKVTL GPKGRNVVLE KKWGAPTITN
60 70 80 90 100
DGVSIAKEIE LEDPYEKIGA ELVKEVAKKT DDVAGDGTTT ATVLAQALVK
110 120 130 140 150
EGLRNVAAGA NPMALKRGIE KAVEAVSGAL LEQAKDVETK EQIASTASIS
160 170 180 190 200
AADTQIGELI AEAMDKVGKE GVITVEEFQT FGLELELTEG MGFDKGYISA
210 220 230 240 250
YFATDMERME ASLDDPYILI ANSKIGNVKD LLPLLEKVMQ SGKPLLIIAE
260 270 280 290 300
DVEGEALSTL VVNKIRGTFK SVAVKAPGFG DRRKAMLGDI AILTGGEVIS
310 320 330 340 350
EEVGLKLENA GLDLLGRARK VVITKDETTI VDGAGDTDQV NGRVAQIRAE
360 370 380 390 400
IENSDSDYDR EKLQERLANV AGGVAVIKAG AATEVELKER KERKHRIEDA
410 420 430 440 450
VRNAKAAVEE GIVAGGGVAL LQASQVFEKL ELTGDEATGA NAVKLALEAP
460 470
LKQIPSTAVS RAAWSWRRCA TSPWATA
Length:477
Mass (Da):50,661
Last modified:January 23, 2007 - v3
Checksum:i2BAEA494832A628C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95971 Genomic DNA. Translation: CAA65226.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95971 Genomic DNA. Translation: CAA65226.1.

3D structure databases

ProteinModelPortaliO33658.
SMRiO33658. Positions 2-458.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH602_STRLI
AccessioniPrimary (citable) accession number: O33658
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.