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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity).By similarity

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-209-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferase (EC:2.1.2.9)
Gene namesi
Name:fmt
Ordered Locus Names:RT0198
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Methionyl-tRNA formyltransferasePRO_0000083037Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0198.

Structurei

3D structure databases

ProteinModelPortaliO33582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni108 – 1114Tetrahydrofolate (THF) bindingBy similarity

Sequence similaritiesi

Belongs to the Fmt family.Curated

Phylogenomic databases

eggNOGiENOG4105CAE. Bacteria.
COG0223. LUCA.
HOGENOMiHOG000261177.
KOiK00604.
OMAiSIIIKVR.
OrthoDBiPOG091H01YM.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
[Graphical view]
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.

Sequencei

Sequence statusi: Complete.

O33582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVIFMGTPE FAVPTLKKLI IHHEVKAVFT QQPKAKGRGL YLAKSPIHQL
60 70 80 90 100
AFEHQIPVYS PSTLRNDETI NLINKVDADI IVVIAYGFIV PKAILEAKKY
110 120 130 140 150
GCLNIHPSDL PRHRGAAPLQ RTIIEGDLKS SVCIMRMDSG LDTGDILLKE
160 170 180 190 200
DLNLEKRITL DELSNRCAHL GAELLIQTLA NIDNIVPVKQ SSNGVTYAHK
210 220 230 240 250
LTKAEGKINW YESAYSIDCK IRGMNPWPGA YFSYNDKIIK ILEAEYLNYN
260 270 280 290 300
HHFIPGTVIS NKLEIACGSG ILRVTKLQQE SKKALNIEAF LRGTNILKDT

ILK
Length:303
Mass (Da):33,913
Last modified:November 9, 2004 - v2
Checksum:i536F48A4CFDFE38F
GO

Sequence cautioni

The sequence AAU03682 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03682.1. Different initiation.
Y13133 Genomic DNA. Translation: CAA73600.1.
RefSeqiWP_011190669.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03682; AAU03682; RT0198.
KEGGirty:RT0198.
PATRICi17909580. VBIRicTyp34752_0209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03682.1. Different initiation.
Y13133 Genomic DNA. Translation: CAA73600.1.
RefSeqiWP_011190669.1. NC_006142.1.

3D structure databases

ProteinModelPortaliO33582.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0198.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03682; AAU03682; RT0198.
KEGGirty:RT0198.
PATRICi17909580. VBIRicTyp34752_0209.

Phylogenomic databases

eggNOGiENOG4105CAE. Bacteria.
COG0223. LUCA.
HOGENOMiHOG000261177.
KOiK00604.
OMAiSIIIKVR.
OrthoDBiPOG091H01YM.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-209-MONOMER.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
[Graphical view]
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFMT_RICTY
AccessioniPrimary (citable) accession number: O33582
Secondary accession number(s): Q68XG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 9, 2004
Last modified: September 7, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.