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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciRTYP257363:G1G0L-204-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:RT0198
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000830371 – 303Methionyl-tRNA formyltransferaseAdd BLAST303

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0198

Structurei

3D structure databases

ProteinModelPortaliO33582
SMRiO33582
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 111Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

O33582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVIFMGTPE FAVPTLKKLI IHHEVKAVFT QQPKAKGRGL YLAKSPIHQL
60 70 80 90 100
AFEHQIPVYS PSTLRNDETI NLINKVDADI IVVIAYGFIV PKAILEAKKY
110 120 130 140 150
GCLNIHPSDL PRHRGAAPLQ RTIIEGDLKS SVCIMRMDSG LDTGDILLKE
160 170 180 190 200
DLNLEKRITL DELSNRCAHL GAELLIQTLA NIDNIVPVKQ SSNGVTYAHK
210 220 230 240 250
LTKAEGKINW YESAYSIDCK IRGMNPWPGA YFSYNDKIIK ILEAEYLNYN
260 270 280 290 300
HHFIPGTVIS NKLEIACGSG ILRVTKLQQE SKKALNIEAF LRGTNILKDT

ILK
Length:303
Mass (Da):33,913
Last modified:November 9, 2004 - v2
Checksum:i536F48A4CFDFE38F
GO

Sequence cautioni

The sequence AAU03682 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA Translation: AAU03682.1 Different initiation.
Y13133 Genomic DNA Translation: CAA73600.1
RefSeqiWP_011190669.1, NC_006142.1

Genome annotation databases

EnsemblBacteriaiAAU03682; AAU03682; RT0198
KEGGirty:RT0198

Similar proteinsi

Entry informationi

Entry nameiFMT_RICTY
AccessioniPrimary (citable) accession number: O33582
Secondary accession number(s): Q68XG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 9, 2004
Last modified: March 28, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health