O33570 (CCMA_RHOS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c biogenesis ATP-binding export protein CcmA
EC=3.6.3.41

Alternative name(s):
Heme exporter protein A

Gene names

Name:	ccmA
Ordered Locus Names:	RHOS4_03800
ORF Names:	RSP_1801

Organism

Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

Taxonomic identifier

272943 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity. HAMAP MF_01707
Catalytic activity	ATP + H2O + heme(In) = ADP + phosphate + heme(Out). HAMAP MF_01707
Subunit structure	The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB) By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01707.
Sequence similarities	Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW heme-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Cytochrome c biogenesis ATP-binding export protein CcmA HAMAP MF_01707		PRO_0000092205
Regions
	Domain	3 – 209	207	ABC transporter
	Nucleotide binding	35 – 42	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	O33570 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 72C42BE3B1804D8A	FASTA	210	21,817
	10 20 30 40 50 60 MDLTVTNLAC ARGGVTVLER VSFRLSRGAA LILRGPNGIG KTTLLRTVAG LQPAVAGEIS 70 80 90 100 110 120 MPPEAVAYAA HADGLKATLT VAENLAFWAA IYGTDRAARA IERMNLAALA DRQAQNLSAG 130 140 150 160 170 180 QKRRLGLARL LVTGRPLWVL DEPTVSLDAA SVALFGDVVR THLAEGGAAL MATHIDLGLA 190 200 210 EAEVLDLAPY RAETPAGTEP ADDPFAGVTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of putative cytochrome c maturation genes (ccmABCDG) from Rhodobacter sphaeroides." Patterson C.S., Donohue T.J. Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U83136 Genomic DNA. Translation: AAB61906.1. CP000143 Genomic DNA. Translation: ABA77948.1.
RefSeq	YP_351849.1. NC_007493.1.
3D structure databases
ProteinModelPortal	O33570.
ModBase	Search...
Protein-protein interaction databases
STRING	O33570.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3719046.
GenomeReviews	Gene locus RHOS4_03800 in contig CP000143_GR.
KEGG	rsp:RSP_1801.
NMPDR	fig|272943.3.peg.781.
PATRIC	23150563. VBIRhoSph57909_0682.
Phylogenomic databases
eggNOG	COG4133.
HOGENOM	HBG758042.
OMA	NLACARG.
PhylomeDB	O33570.
ProtClustDB	PRK13539.
Enzyme and pathway databases
BioCyc	RSPH272943:RSP_1801-MONOMER.
Family and domain databases
HAMAP	MF_01707. ABC_ATPase_CcmA. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR005895. ABC_transptr_haem_export_CcmA. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K02193.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01189. CcmA. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51243. CCMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCMA_RHOS4

Accession

Primary (citable) accession number: O33570
Secondary accession number(s): Q3J5I6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program