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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:Rmet_2922
OrganismiCupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000784061 – 648Chaperone protein DnaKAdd BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei200Phosphothreonine; by autocatalysisBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO33522.

Expressioni

Inductioni

By stress conditions e.g. heat shock (By similarity).By similarity

Interactioni

Protein-protein interaction databases

STRINGi266264.Rmet_2922.

Structurei

3D structure databases

ProteinModelPortaliO33522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04043.
OMAiEKMAPPQ.
OrthoDBiPOG091H01UE.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIIGIDLG TTNSCVSILE GNTPKVIENS EGARTTPSII AYMEDGEILV
60 70 80 90 100
GAPAKRQAVT NPRNTLYAVK RLIGRKFEEK EVQKDIGLMP YAIVKADNGD
110 120 130 140 150
AWVGVRDQKL APPQVSAEVL RKMKKTAEDY LGEPVTEAVI TVPAYFNDSQ
160 170 180 190 200
RQATKDAGRI AGLDVKRIIN EPTAAALAFG MDKNEKGDRK IAVYDLGGGT
210 220 230 240 250
FDISIIEIAD VDGEKQFEVL STNGDTFLGG EDFDQRIIDY IIGEFKKEQG
260 270 280 290 300
VDLSKDVLAL QRLKEAAEKA KIELSSSQQT EINLPYITAD ASGPKHLNLK
310 320 330 340 350
ITRAKLEALV EELITRTIEP CRTAIKDAGV KVSDIDDVIL VGGMTRMPKV
360 370 380 390 400
QEQVREFFGK EARKDVNPDE AVAVGAAIQG SVLSGDRTDV LLLDVTPLSL
410 420 430 440 450
GIETLGGVMT KMINKNTTIP TKHAQVFSTA DDNQPAVTIK VYQGEREMAT
460 470 480 490 500
GNKMLGEFNL EGIAPAPRGT PQIEVSFDID ANGILHVGAK DKATGKENRI
510 520 530 540 550
TIKANSGLSE DEIQRMVKDA EANAEEDKRA RELADARNQA DALIHSTRKA
560 570 580 590 600
LGEYGEKLEA GEKEKIEAAI KDLEDAARGG DKAEIDAKVN ALSEASQKLG
610 620 630 640
EKVYADMQAQ AGEGAAAGAG AAGGAQQQAQ PQDDNVVDAE FKEVNDKK
Length:648
Mass (Da):69,787
Last modified:July 11, 2006 - v2
Checksum:i0E962FFF93C6CCA4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119 – 120VL → AV in CAA04955 (Ref. 1) Curated2
Sequence conflicti149 – 151SQR → AQC in CAA04955 (Ref. 1) Curated3
Sequence conflicti247K → R in CAA04955 (Ref. 1) Curated1
Sequence conflicti263L → C in CAA04955 (Ref. 1) Curated1
Sequence conflicti553 – 581EYGEK…ARGGD → RVRREARSWREGKDRSRDQG PGRRRPRVN in CAA04955 (Ref. 1) CuratedAdd BLAST29
Sequence conflicti623 – 648GGAQQ…VNDKK → RFSSRPSRRRQRVGCRVQGS ERQEVIGDG (Ref. 1) CuratedAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001727 Genomic DNA. Translation: CAA04955.1.
CP000352 Genomic DNA. Translation: ABF09795.1.
RefSeqiWP_011517467.1. NC_007973.1.

Genome annotation databases

EnsemblBacteriaiABF09795; ABF09795; Rmet_2922.
GeneIDi24151673.
KEGGirme:Rmet_2922.
PATRICi20290477. VBIRalMet4734_3314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001727 Genomic DNA. Translation: CAA04955.1.
CP000352 Genomic DNA. Translation: ABF09795.1.
RefSeqiWP_011517467.1. NC_007973.1.

3D structure databases

ProteinModelPortaliO33522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266264.Rmet_2922.

Proteomic databases

PRIDEiO33522.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF09795; ABF09795; Rmet_2922.
GeneIDi24151673.
KEGGirme:Rmet_2922.
PATRICi20290477. VBIRalMet4734_3314.

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04043.
OMAiEKMAPPQ.
OrthoDBiPOG091H01UE.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_CUPMC
AccessioniPrimary (citable) accession number: O33522
Secondary accession number(s): Q1LJ81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 11, 2006
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.