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Protein

Putative glutamine amidotransferase Rv2859c

Gene

Rv2859c

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei177NucleophilePROSITE-ProRule annotation1
Active sitei277PROSITE-ProRule annotation1
Active sitei279PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7110-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glutamine amidotransferase Rv2859c (EC:2.4.2.-)
Gene namesi
Ordered Locus Names:Rv2859c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2859c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003961151 – 308Putative glutamine amidotransferase Rv2859cAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki289Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiO33341.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2859c.

Structurei

3D structure databases

ProteinModelPortaliO33341.
SMRiO33341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 301Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd BLAST224

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiENOG4108Z86. Bacteria.
COG2071. LUCA.
HOGENOMiHOG000035714.
InParanoidiO33341.
KOiK07010.
OMAiGFITACR.
PhylomeDBiO33341.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR011697. Peptidase_C26.
[Graphical view]
PfamiPF07722. Peptidase_C26. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSASRSDG GDPLRPASPR LRSPVSDGGD PLRPASPRLR SPVSDGGDPL
60 70 80 90 100
RPASPRLRSP LGASRPVVGL TAYLEQVRTG VWDIPAGYLP ADYFEGITMA
110 120 130 140 150
GGVAVLLPPQ PVDPESVGCV LDSLHALVIT GGYDLDPAAY GQEPHPATDH
160 170 180 190 200
PRPGRDAWEF ALLRGALQRG MPVLGICRGT QVLNVALGGT LHQHLPDILG
210 220 230 240 250
HSGHRAGNGV FTRLPVHTAS GTRLAELIGE SADVPCYHHQ AIDQVGEGLV
260 270 280 290 300
VSAVDVDGVI EALELPGDTF VLAVQWHPEK SLDDLRLFKA LVDAASGYAG

RQSQAEPR
Length:308
Mass (Da):32,442
Last modified:January 1, 1998 - v1
Checksum:i81F131E4252DC93B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45660.1.
PIRiE70885.
RefSeqiNP_217375.1. NC_000962.3.
WP_003900586.1. NZ_CP009480.1.

Genome annotation databases

EnsemblBacteriaiCCP45660; CCP45660; Rv2859c.
GeneIDi887495.
KEGGimtu:Rv2859c.
PATRICi18154949. VBIMycTub87468_3188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45660.1.
PIRiE70885.
RefSeqiNP_217375.1. NC_000962.3.
WP_003900586.1. NZ_CP009480.1.

3D structure databases

ProteinModelPortaliO33341.
SMRiO33341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv2859c.

Proteomic databases

PaxDbiO33341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP45660; CCP45660; Rv2859c.
GeneIDi887495.
KEGGimtu:Rv2859c.
PATRICi18154949. VBIMycTub87468_3188.

Organism-specific databases

TubercuListiRv2859c.

Phylogenomic databases

eggNOGiENOG4108Z86. Bacteria.
COG2071. LUCA.
HOGENOMiHOG000035714.
InParanoidiO33341.
KOiK07010.
OMAiGFITACR.
PhylomeDBiO33341.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7110-MONOMER.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR011697. Peptidase_C26.
[Graphical view]
PfamiPF07722. Peptidase_C26. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY2859_MYCTU
AccessioniPrimary (citable) accession number: O33341
Secondary accession number(s): L0TAV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.