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Protein
Submitted name:

Phosphopantetheinyl transferase PptT (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase)

Gene

pptT

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei48Coenzyme ACombined sources1
Binding sitei56Coenzyme ACombined sources1
Metal bindingi114MagnesiumCombined sources1
Metal bindingi115Magnesium; via carbonyl oxygenCombined sources1
Metal bindingi116MagnesiumCombined sources1
Binding sitei123Coenzyme ACombined sources1
Binding sitei157Coenzyme ACombined sources1
Binding sitei171Coenzyme A; via carbonyl oxygenCombined sources1

GO - Molecular functioni

  • holo-[acyl-carrier-protein] synthase activity Source: MTBBASE
  • magnesium ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionTransferaseSAAS annotationImported
LigandMagnesiumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphopantetheinyl transferase PptT (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase)Imported
Gene namesi
Name:pptTImported
Ordered Locus Names:Rv2794cImported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • enterobactin synthetase complex Source: InterPro
  • plasma membrane Source: MTBBASE

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2794c.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QJKX-ray1.59A1-227[»]
4QVHX-ray1.75A/B1-227[»]
4U89X-ray1.40A1-227[»]
SMRiO33336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni75 – 81Coenzyme A bindingCombined sources7
Regioni92 – 93Coenzyme A bindingCombined sources2
Regioni114 – 116Coenzyme A bindingCombined sources3
Regioni161 – 164Coenzyme A bindingCombined sources4

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108S6E. Bacteria.
COG2977. LUCA.
HOGENOMiHOG000276816.
OMAiLTHCDGY.

Family and domain databases

Gene3Di3.90.470.20. 2 hits.
InterProiView protein in InterPro
IPR008278. 4-PPantetheinyl_Trfase_dom.
IPR037143. 4-PPantetheinyl_Trfase_dom_sf.
IPR003542. Enbac_synth_compD-like.
PfamiView protein in Pfam
PF01648. ACPS. 1 hit.
PRINTSiPR01399. ENTSNTHTASED.
SUPFAMiSSF56214. SSF56214. 1 hit.

Sequencei

Sequence statusi: Complete.

O33336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVGTLVASV LPATVFEDLA YAELYSDPPG LTPLPEEAPL IARSVAKRRN
60 70 80 90 100
EFITVRHCAR IALDQLGVPP APILKGDKGE PCWPDGMVGS LTHCAGYRGA
110 120 130 140 150
VVGRRDAVRS VGIDAEPHDV LPNGVLDAIS LPAERADMPR TMPAALHWDR
160 170 180 190 200
ILFCAKEATY KAWFPLTKRW LGFEDAHITF ETDSTGWTGR FVSRILIDGS
210 220
TLSGPPLTTL RGRWSVERGL VLTAIVL
Length:227
Mass (Da):24,709
Last modified:January 1, 1998 - v1
Checksum:i60C988873EE28472
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45593.1.
RefSeqiNP_217310.1. NC_000962.3.
WP_003917055.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR15566; AIR15566; LH57_15260.
CCP45593; CCP45593; Rv2794c.
GeneIDi888226.
KEGGimtu:Rv2794c.
mtv:RVBD_2794c.
PATRICifig|83332.111.peg.3107.

Similar proteinsi

Entry informationi

Entry nameiO33336_MYCTU
AccessioniPrimary (citable) accession number: O33336
Secondary accession number(s): I6XFB3
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported