Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

4'-phosphopantetheinyl transferase

Gene

pptT

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481Coenzyme ACombined sources
Binding sitei56 – 561Coenzyme ACombined sources
Binding sitei114 – 1141Coenzyme ACombined sources
Binding sitei157 – 1571Coenzyme ACombined sources
Binding sitei171 – 1711Coenzyme A; via carbonyl oxygenCombined sources

GO - Molecular functioni

  • holo-[acyl-carrier-protein] synthase activity Source: MTBBASE
  • magnesium ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseSAAS annotationImported

Enzyme and pathway databases

BioCyciMTBRV:RV2794C-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
4'-phosphopantetheinyl transferaseImported
Submitted name:
Phosphopantetheinyl transferase PptT (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase)Imported
Gene namesi
Name:pptTImported
Ordered Locus Names:LH57_15260Imported, Rv2794cImported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • enterobactin synthetase complex Source: InterPro
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2794c.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4QJKX-ray1.59A1-227[»]
4QVHX-ray1.75A/B1-227[»]
4U89X-ray1.40A1-227[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 18475ACPSInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni78 – 792Coenzyme A bindingCombined sources
Regioni92 – 932Coenzyme A bindingCombined sources
Regioni161 – 1644Coenzyme A bindingCombined sources

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108S6E. Bacteria.
COG2977. LUCA.
HOGENOMiHOG000276816.
OMAiSISHCAD.
OrthoDBiEOG6BS8PH.

Family and domain databases

Gene3Di3.90.470.20. 1 hit.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR003542. Enbac_synth_compD-like.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
PRINTSiPR01399. ENTSNTHTASED.
SUPFAMiSSF56214. SSF56214. 1 hit.

Sequencei

Sequence statusi: Complete.

O33336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVGTLVASV LPATVFEDLA YAELYSDPPG LTPLPEEAPL IARSVAKRRN
60 70 80 90 100
EFITVRHCAR IALDQLGVPP APILKGDKGE PCWPDGMVGS LTHCAGYRGA
110 120 130 140 150
VVGRRDAVRS VGIDAEPHDV LPNGVLDAIS LPAERADMPR TMPAALHWDR
160 170 180 190 200
ILFCAKEATY KAWFPLTKRW LGFEDAHITF ETDSTGWTGR FVSRILIDGS
210 220
TLSGPPLTTL RGRWSVERGL VLTAIVL
Length:227
Mass (Da):24,709
Last modified:January 1, 1998 - v1
Checksum:i60C988873EE28472
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR15566.1.
AL123456 Genomic DNA. Translation: CCP45593.1.
RefSeqiNP_217310.1. NC_000962.3.
WP_003917055.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR15566; AIR15566; LH57_15260.
CCP45593; CCP45593; Rv2794c.
GeneIDi888226.
KEGGimtu:Rv2794c.
mtv:RVBD_2794c.
PATRICi18154799. VBIMycTub87468_3113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR15566.1.
AL123456 Genomic DNA. Translation: CCP45593.1.
RefSeqiNP_217310.1. NC_000962.3.
WP_003917055.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4QJKX-ray1.59A1-227[»]
4QVHX-ray1.75A/B1-227[»]
4U89X-ray1.40A1-227[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv2794c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR15566; AIR15566; LH57_15260.
CCP45593; CCP45593; Rv2794c.
GeneIDi888226.
KEGGimtu:Rv2794c.
mtv:RVBD_2794c.
PATRICi18154799. VBIMycTub87468_3113.

Phylogenomic databases

eggNOGiENOG4108S6E. Bacteria.
COG2977. LUCA.
HOGENOMiHOG000276816.
OMAiSISHCAD.
OrthoDBiEOG6BS8PH.

Enzyme and pathway databases

BioCyciMTBRV:RV2794C-MONOMER.

Family and domain databases

Gene3Di3.90.470.20. 1 hit.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR003542. Enbac_synth_compD-like.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
PRINTSiPR01399. ENTSNTHTASED.
SUPFAMiSSF56214. SSF56214. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported and H37RvImported.
  2. "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv."
    Camus J.C., Pryor M.J., Medigue C., Cole S.T.
    Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  5. Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C., Zhang K., Xu W.W., Yu Z.J., Xia X.Z.
    Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  6. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported and H37RvImported.

Entry informationi

Entry nameiO33336_MYCTU
AccessioniPrimary (citable) accession number: O33336
Secondary accession number(s): I6XFB3
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.