O33199 (O33199_MYCTU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
MutT/nudix family protein EMBL AAK46008.1

Submitted name:
NUDIX hydrolase EMBL CCP44465.1

Gene names

Ordered Locus Names:

MT1739, Rv1700 EMBL CCP44465.1

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Manganese PDB 1MR2 PDB 1MQW Metal-binding PDB 1MR2 PDB 1MQW
Molecular function	Hydrolase EMBL CCP44465.1
Technical term	3D-structure PDB 1MR2 PDB 1MQW PDB 1MP2 PDB 1MQE PDB 1MK1 Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from direct assay Ref.4. Source: MTBBASE
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	142	1	Proton donor/acceptor PDB 1MQW
	Metal binding	93	1	Manganese PDB 1MQW
	Metal binding	97	1	Manganese PDB 1MQW
	Metal binding	142	1	Manganese PDB 1MQW
	Binding site	64	1	Substrate PDB 1MQW

Sequences

	Sequence		Length	Mass (Da)
	O33199 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 7FB78C9C984FA85E	FASTA	207	22,893
	10 20 30 40 50 60 MAEHDFETIS SETLHTGAIF ALRRDQVRMP GGGIVTREVV EHFGAVAIVA MDDNGNIPMV 70 80 90 100 110 120 YQYRHTYGRR LWELPAGLLD VAGEPPHLTA ARELREEVGL QASTWQVLVD LDTAPGFSDE 130 140 150 160 170 180 SVRVYLATGL REVGRPEAHH EEADMTMGWY PIAEAARRVL RGEIVNSIAI AGVLAVHAVT 190 200 TGFAQPRPLD TEWIDRPTAF AARRAER

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv and H37Rv EMBL CCP44465.1.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv." Camus J.C., Pryor M.J., Medigue C., Cole S.T. Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP44465.1.
[4]	"Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis." Kang L.W., Gabelli S.B., Cunningham J.E., O'Handley S.F., Amzel L.M. Structure 11:1015-1023(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH MANGANESE, ACTIVE SITE.
[5]	"TubercuList--10 years after." Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. Tuberculosis 91:1-7(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP44465.1.
[6]	Lew J.M. Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP44465.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000516 Genomic DNA. Translation: AAK46008.1.
AL123456 Genomic DNA. Translation: CCP44465.1.

PIR

C70503.

RefSeq

NP_216216.1. NC_000962.3.
NP_336194.1. NC_002755.2.
YP_006515092.1. NC_018143.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1MK1	X-ray	2.00	A	1-207	[»]
1MP2	X-ray	2.30	A	1-207	[»]
1MQE	X-ray	2.00	A	1-207	[»]
1MQW	X-ray	2.30	A	1-207	[»]
1MR2	X-ray	2.30	A	1-207	[»]

SMR

O33199. Positions 5-204.

ModBase

Search...

Protein-protein interaction databases

STRING

83332.Rv1700.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAK46008; AAK46008; MT1739.

GeneID

13316482.
885049.
923967.

KEGG

mtc:MT1739.
mtu:Rv1700.
mtv:RVBD_1700.

PATRIC

18125576. VBIMycTub22151_1902.

Organism-specific databases

TubercuList

Rv1700.

Phylogenomic databases

HOGENOM

HOG000045854.

KO

K01515.

OMA

HPGSVAV.

ProtClustDB

CLSK791335.

Family and domain databases

Gene3D

3.90.79.10. 1 hit.

InterPro

IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]

Pfam

PF00293. NUDIX. 1 hit.
[Graphical view]

SUPFAM

SSF55811. NUDIX_hydrolase. 1 hit.

PROSITE

PS51462. NUDIX. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

O33199.

Entry information

Entry name

O33199_MYCTU

Accession

Primary (citable) accession number: O33199
Secondary accession number(s): F2GK38, Q7D845

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)