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O33199

- O33199_MYCTO

UniProt

O33199 - O33199_MYCTO

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Protein
Submitted name:

ADP-ribose pyrophosphatase

Gene

MT1739

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641SubstrateImported
Metal bindingi93 – 931ManganeseImported
Metal bindingi97 – 971ManganeseImported
Active sitei142 – 1421Proton donor/acceptorImported
Metal bindingi142 – 1421ManganeseImported

GO - Molecular functioni

  1. hydrolase activity Source: InterPro
  2. manganese ion binding Source: MTBBASE
Complete GO annotation...

Keywords - Ligandi

ManganeseImported, Metal-bindingImported

Enzyme and pathway databases

BioCyciMTBRV:RV1700-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
ADP-ribose pyrophosphataseImported
Submitted name:
MutT/nudix family proteinImported
Gene namesi
Ordered Locus Names:MT1739Imported
ORF Names:V735_01744Imported
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)Imported
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001020: Chromosome

Organism-specific databases

TubercuListiRv1700.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1700.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MK1X-ray2.00A1-207[»]
1MP2X-ray2.30A1-207[»]
1MQEX-ray2.00A1-207[»]
1MQWX-ray2.30A1-207[»]
1MR2X-ray2.30A1-207[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO33199.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000045854.
KOiK01515.
OMAiPGENPLH.
OrthoDBiEOG6VMTQG.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33199-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEHDFETIS SETLHTGAIF ALRRDQVRMP GGGIVTREVV EHFGAVAIVA
60 70 80 90 100
MDDNGNIPMV YQYRHTYGRR LWELPAGLLD VAGEPPHLTA ARELREEVGL
110 120 130 140 150
QASTWQVLVD LDTAPGFSDE SVRVYLATGL REVGRPEAHH EEADMTMGWY
160 170 180 190 200
PIAEAARRVL RGEIVNSIAI AGVLAVHAVT TGFAQPRPLD TEWIDRPTAF

AARRAER
Length:207
Mass (Da):22,893
Last modified:January 1, 1998 - v1
Checksum:i7FB78C9C984FA85E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000516 Genomic DNA. Translation: AAK46008.1.
JLBH01000002 Genomic DNA. Translation: KBN12908.1.
PIRiC70503.
RefSeqiNP_336194.1. NC_002755.2.

Genome annotation databases

EnsemblBacteriaiAAK46008; AAK46008; MT1739.
CCP44465; CCP44465; Rv1700.
GeneIDi923967.
KEGGimtc:MT1739.
PATRICi18125576. VBIMycTub22151_1902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000516 Genomic DNA. Translation: AAK46008.1 .
JLBH01000002 Genomic DNA. Translation: KBN12908.1 .
PIRi C70503.
RefSeqi NP_336194.1. NC_002755.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MK1 X-ray 2.00 A 1-207 [» ]
1MP2 X-ray 2.30 A 1-207 [» ]
1MQE X-ray 2.00 A 1-207 [» ]
1MQW X-ray 2.30 A 1-207 [» ]
1MR2 X-ray 2.30 A 1-207 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 83332.Rv1700.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK46008 ; AAK46008 ; MT1739 .
CCP44465 ; CCP44465 ; Rv1700 .
GeneIDi 923967.
KEGGi mtc:MT1739.
PATRICi 18125576. VBIMycTub22151_1902.

Organism-specific databases

TubercuListi Rv1700.

Phylogenomic databases

HOGENOMi HOG000045854.
KOi K01515.
OMAi PGENPLH.
OrthoDBi EOG6VMTQG.

Enzyme and pathway databases

BioCyci MTBRV:RV1700-MONOMER.

Miscellaneous databases

EvolutionaryTracei O33199.

Family and domain databases

Gene3Di 3.90.79.10. 1 hit.
InterProi IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view ]
Pfami PF00293. NUDIX. 1 hit.
[Graphical view ]
SUPFAMi SSF55811. SSF55811. 1 hit.
PROSITEi PS51462. NUDIX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CDC 1551 / OshkoshImported and CDC1551Imported.
  2. "Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis."
    Kang L.W., Gabelli S.B., Cunningham J.E., O'Handley S.F., Amzel L.M.
    Structure 11:1015-1023(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH MANGANESE, ACTIVE SITE.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CDC1551.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Cdc1551Imported.

Entry informationi

Entry nameiO33199_MYCTO
AccessioniPrimary (citable) accession number: O33199
Secondary accession number(s): F2GK38, Q7D845
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3