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Protein
Submitted name:

ADP-ribose pyrophosphatase

Gene

MT1739

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641SubstrateCombined sources
Metal bindingi93 – 931ManganeseCombined sources
Metal bindingi97 – 971ManganeseCombined sources
Active sitei142 – 1421Proton donor/acceptorCombined sources
Metal bindingi142 – 1421ManganeseCombined sources

GO - Molecular functioni

  1. hydrolase activity Source: InterPro
  2. manganese ion binding Source: MTBBASE
Complete GO annotation...

Keywords - Ligandi

ManganeseCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyciMTBRV:RV1700-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
ADP-ribose pyrophosphataseImported
Submitted name:
MutT/nudix family proteinImported
Gene namesi
Ordered Locus Names:MT1739Imported
ORF Names:V735_01744Imported
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)Imported
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001020 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiO33199.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1700.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MK1X-ray2.00A1-207[»]
1MP2X-ray2.30A1-207[»]
1MQEX-ray2.00A1-207[»]
1MQWX-ray2.30A1-207[»]
1MR2X-ray2.30A1-207[»]
ProteinModelPortaliO33199.
SMRiO33199. Positions 5-204.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO33199.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000045854.
InParanoidiO33199.
KOiK01515.
OrthoDBiEOG6VMTQG.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEHDFETIS SETLHTGAIF ALRRDQVRMP GGGIVTREVV EHFGAVAIVA
60 70 80 90 100
MDDNGNIPMV YQYRHTYGRR LWELPAGLLD VAGEPPHLTA ARELREEVGL
110 120 130 140 150
QASTWQVLVD LDTAPGFSDE SVRVYLATGL REVGRPEAHH EEADMTMGWY
160 170 180 190 200
PIAEAARRVL RGEIVNSIAI AGVLAVHAVT TGFAQPRPLD TEWIDRPTAF

AARRAER
Length:207
Mass (Da):22,893
Last modified:December 31, 1997 - v1
Checksum:i7FB78C9C984FA85E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK46008.1.
JLBH01000002 Genomic DNA. Translation: KBN12908.1.
PIRiC70503.
RefSeqiNP_336194.1. NC_002755.2.

Genome annotation databases

EnsemblBacteriaiAAK46008; AAK46008; MT1739.
KBN12908; KBN12908; V735_01744.
KEGGimtc:MT1739.
PATRICi18125576. VBIMycTub22151_1902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK46008.1.
JLBH01000002 Genomic DNA. Translation: KBN12908.1.
PIRiC70503.
RefSeqiNP_336194.1. NC_002755.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MK1X-ray2.00A1-207[»]
1MP2X-ray2.30A1-207[»]
1MQEX-ray2.00A1-207[»]
1MQWX-ray2.30A1-207[»]
1MR2X-ray2.30A1-207[»]
ProteinModelPortaliO33199.
SMRiO33199. Positions 5-204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1700.

Proteomic databases

PRIDEiO33199.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK46008; AAK46008; MT1739.
KBN12908; KBN12908; V735_01744.
KEGGimtc:MT1739.
PATRICi18125576. VBIMycTub22151_1902.

Phylogenomic databases

HOGENOMiHOG000045854.
InParanoidiO33199.
KOiK01515.
OrthoDBiEOG6VMTQG.

Enzyme and pathway databases

BioCyciMTBRV:RV1700-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO33199.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CDC 1551 / OshkoshImported and CDC1551Imported.
  2. "Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis."
    Kang L.W., Gabelli S.B., Cunningham J.E., O'Handley S.F., Amzel L.M.
    Structure 11:1015-1023(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH MANGANESE, ACTIVE SITE.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CDC1551.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Cdc1551Imported.

Entry informationi

Entry nameiO33199_MYCTO
AccessioniPrimary (citable) accession number: O33199
Secondary accession number(s): F2GK38, Q7D845
Entry historyi
Integrated into UniProtKB/TrEMBL: December 31, 1997
Last sequence update: December 31, 1997
Last modified: March 31, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.