Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O33199

- O33199_MYCTO

UniProt

O33199 - O33199_MYCTO

Protein
Submitted name:

ADP-ribose pyrophosphatase

Gene

MT1739

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei64 – 641SubstrateImported
    Metal bindingi93 – 931ManganeseImported
    Metal bindingi97 – 971ManganeseImported
    Active sitei142 – 1421Proton donor/acceptorImported
    Metal bindingi142 – 1421ManganeseImported

    GO - Molecular functioni

    1. hydrolase activity Source: InterPro
    2. manganese ion binding Source: MTBBASE

    Keywords - Ligandi

    ManganeseImported, Metal-bindingImported

    Enzyme and pathway databases

    BioCyciMTBRV:RV1700-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ADP-ribose pyrophosphataseImported
    Submitted name:
    MutT/nudix family proteinImported
    Gene namesi
    Ordered Locus Names:MT1739Imported
    ORF Names:V735_01744Imported
    OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)Imported
    Taxonomic identifieri83331 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001020: Chromosome

    Organism-specific databases

    TubercuListiRv1700.

    Interactioni

    Protein-protein interaction databases

    STRINGi83332.Rv1700.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1MK1X-ray2.00A1-207[»]
    1MP2X-ray2.30A1-207[»]
    1MQEX-ray2.00A1-207[»]
    1MQWX-ray2.30A1-207[»]
    1MR2X-ray2.30A1-207[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO33199.

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000045854.
    KOiK01515.
    OMAiPGENPLH.
    OrthoDBiEOG6VMTQG.

    Family and domain databases

    Gene3Di3.90.79.10. 1 hit.
    InterProiIPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    [Graphical view]
    PfamiPF00293. NUDIX. 1 hit.
    [Graphical view]
    SUPFAMiSSF55811. SSF55811. 1 hit.
    PROSITEiPS51462. NUDIX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O33199-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEHDFETIS SETLHTGAIF ALRRDQVRMP GGGIVTREVV EHFGAVAIVA    50
    MDDNGNIPMV YQYRHTYGRR LWELPAGLLD VAGEPPHLTA ARELREEVGL 100
    QASTWQVLVD LDTAPGFSDE SVRVYLATGL REVGRPEAHH EEADMTMGWY 150
    PIAEAARRVL RGEIVNSIAI AGVLAVHAVT TGFAQPRPLD TEWIDRPTAF 200
    AARRAER 207
    Length:207
    Mass (Da):22,893
    Last modified:January 1, 1998 - v1
    Checksum:i7FB78C9C984FA85E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000516 Genomic DNA. Translation: AAK46008.1.
    JLBH01000002 Genomic DNA. Translation: KBN12908.1.
    PIRiC70503.
    RefSeqiNP_336194.1. NC_002755.2.

    Genome annotation databases

    EnsemblBacteriaiAAK46008; AAK46008; MT1739.
    CCP44465; CCP44465; Rv1700.
    GeneIDi923967.
    KEGGimtc:MT1739.
    PATRICi18125576. VBIMycTub22151_1902.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000516 Genomic DNA. Translation: AAK46008.1 .
    JLBH01000002 Genomic DNA. Translation: KBN12908.1 .
    PIRi C70503.
    RefSeqi NP_336194.1. NC_002755.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1MK1 X-ray 2.00 A 1-207 [» ]
    1MP2 X-ray 2.30 A 1-207 [» ]
    1MQE X-ray 2.00 A 1-207 [» ]
    1MQW X-ray 2.30 A 1-207 [» ]
    1MR2 X-ray 2.30 A 1-207 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 83332.Rv1700.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK46008 ; AAK46008 ; MT1739 .
    CCP44465 ; CCP44465 ; Rv1700 .
    GeneIDi 923967.
    KEGGi mtc:MT1739.
    PATRICi 18125576. VBIMycTub22151_1902.

    Organism-specific databases

    TubercuListi Rv1700.

    Phylogenomic databases

    HOGENOMi HOG000045854.
    KOi K01515.
    OMAi PGENPLH.
    OrthoDBi EOG6VMTQG.

    Enzyme and pathway databases

    BioCyci MTBRV:RV1700-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O33199.

    Family and domain databases

    Gene3Di 3.90.79.10. 1 hit.
    InterProi IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    [Graphical view ]
    Pfami PF00293. NUDIX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55811. SSF55811. 1 hit.
    PROSITEi PS51462. NUDIX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CDC 1551 / OshkoshImported and CDC1551Imported.
    2. "Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis."
      Kang L.W., Gabelli S.B., Cunningham J.E., O'Handley S.F., Amzel L.M.
      Structure 11:1015-1023(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH MANGANESE, ACTIVE SITE.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CDC1551.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Cdc1551Imported.

    Entry informationi

    Entry nameiO33199_MYCTO
    AccessioniPrimary (citable) accession number: O33199
    Secondary accession number(s): F2GK38, Q7D845
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3