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O33113

- ILVH_MYCLE

UniProt

O33113 - ILVH_MYCLE

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Protein

Acetolactate synthase small subunit

Gene
ilvH, ilvN, ML1695, MLCB637.21
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2 pyruvate = 2-acetolactate + CO2.

Pathwayi

GO - Molecular functioni

  1. acetolactate synthase activity Source: UniProtKB-EC
  2. amino acid binding Source: InterPro

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
  2. valine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00047; UER00055.
UPA00049; UER00059.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetolactate synthase small subunit (EC:2.2.1.6)
Alternative name(s):
Acetohydroxy-acid synthase small subunit
Short name:
AHAS
Short name:
ALS
Gene namesi
Name:ilvH
Synonyms:ilvN
Ordered Locus Names:ML1695
ORF Names:MLCB637.21
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1695.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169Acetolactate synthase small subunitPRO_0000151415Add
BLAST

Interactioni

Subunit structurei

Dimer of large and small chains By similarity.

Protein-protein interaction databases

STRINGi272631.ML1695.

Structurei

3D structure databases

ProteinModelPortaliO33113.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8578ACTAdd
BLAST

Sequence similaritiesi

Contains 1 ACT domain.

Phylogenomic databases

eggNOGiCOG0440.
HOGENOMiHOG000046747.
KOiK01653.
OMAiRGAKGWK.
OrthoDBiEOG6X3W8W.

Family and domain databases

InterProiIPR004789. Acetalactate_synth_ssu.
IPR019455. Acetolactate_synth_ssu_C.
IPR002912. ACT_dom.
[Graphical view]
PfamiPF10369. ALS_ss_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00119. acolac_sm. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33113-1 [UniParc]FASTAAdd to Basket

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MVGLPTHTLS VLVEDTPGVL ARVAALFSRR GFNIESLAVG ATECKTMSRM    50
TIVVSAEETP LEQVTKQLHK LINVIKVVEQ EADNSLSREL ALIKVRAEAG 100
TRSQVIEAVH LFRARVIDVS LESLTVEATG DCSKIEALLR VLEPFGVREI 150
VQSGVVSLSR GPRGIGTVR 169
Length:169
Mass (Da):18,284
Last modified:January 1, 1998 - v1
Checksum:iD450673379C88DD8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z99263 Genomic DNA. Translation: CAB16436.1.
AL583923 Genomic DNA. Translation: CAC30648.1.
PIRiT45414.
RefSeqiNP_302165.1. NC_002677.1.
WP_010908486.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30648; CAC30648; CAC30648.
GeneIDi910799.
KEGGimle:ML1695.
PATRICi18056538. VBIMycLep78757_3198.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z99263 Genomic DNA. Translation: CAB16436.1 .
AL583923 Genomic DNA. Translation: CAC30648.1 .
PIRi T45414.
RefSeqi NP_302165.1. NC_002677.1.
WP_010908486.1. NC_002677.1.

3D structure databases

ProteinModelPortali O33113.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30648 ; CAC30648 ; CAC30648 .
GeneIDi 910799.
KEGGi mle:ML1695.
PATRICi 18056538. VBIMycLep78757_3198.

Organism-specific databases

Lepromai ML1695.

Phylogenomic databases

eggNOGi COG0440.
HOGENOMi HOG000046747.
KOi K01653.
OMAi RGAKGWK.
OrthoDBi EOG6X3W8W.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00055 .
UPA00049 ; UER00059 .

Family and domain databases

InterProi IPR004789. Acetalactate_synth_ssu.
IPR019455. Acetolactate_synth_ssu_C.
IPR002912. ACT_dom.
[Graphical view ]
Pfami PF10369. ALS_ss_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00119. acolac_sm. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiILVH_MYCLE
AccessioniPrimary (citable) accession number: O33113
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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