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O33113 (ILVH_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetolactate synthase small subunit

EC=2.2.1.6
Alternative name(s):
Acetohydroxy-acid synthase small subunit
Short name=AHAS
Short name=ALS
Gene names
Name:ilvH
Synonyms:ilvN
Ordered Locus Names:ML1695
ORF Names:MLCB637.21
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 pyruvate = 2-acetolactate + CO2.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.

Subunit structure

Dimer of large and small chains By similarity.

Sequence similarities

Belongs to the acetolactate synthase small subunit family.

Contains 1 ACT domain.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Branched-chain amino acid biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processisoleucine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

valine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionacetolactate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

amino acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 169169Acetolactate synthase small subunit
PRO_0000151415

Regions

Domain8 – 8578ACT

Sequences

Sequence LengthMass (Da)Tools
O33113 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: D450673379C88DD8

FASTA16918,284
        10         20         30         40         50         60 
MVGLPTHTLS VLVEDTPGVL ARVAALFSRR GFNIESLAVG ATECKTMSRM TIVVSAEETP 

        70         80         90        100        110        120 
LEQVTKQLHK LINVIKVVEQ EADNSLSREL ALIKVRAEAG TRSQVIEAVH LFRARVIDVS 

       130        140        150        160 
LESLTVEATG DCSKIEALLR VLEPFGVREI VQSGVVSLSR GPRGIGTVR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z99263 Genomic DNA. Translation: CAB16436.1.
AL583923 Genomic DNA. Translation: CAC30648.1.
PIRT45414.
RefSeqNP_302165.1. NC_002677.1.

3D structure databases

ProteinModelPortalO33113.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML1695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC30648; CAC30648; CAC30648.
GeneID910799.
KEGGmle:ML1695.
PATRIC18056538. VBIMycLep78757_3198.

Organism-specific databases

LepromaML1695.
CMRSearch...

Phylogenomic databases

eggNOGCOG0440.
HOGENOMHOG000046747.
KOK01653.
OMARGAKGWK.
OrthoDBEOG6X3W8W.

Enzyme and pathway databases

UniPathwayUPA00047; UER00055.
UPA00049; UER00059.

Family and domain databases

InterProIPR004789. Acetalactate_synth_ssu.
IPR019455. Acetolactate_synth_ssu_C.
IPR002912. ACT_dom.
[Graphical view]
PfamPF10369. ALS_ss_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00119. acolac_sm. 1 hit.
PROSITEPS51671. ACT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVH_MYCLE
AccessionPrimary (citable) accession number: O33113
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways