O33113 (ILVH_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetolactate synthase small subunit
EC=2.2.1.6

Alternative name(s):
Acetohydroxy-acid synthase small subunit
Short name=AHAS
Short name=ALS

Gene names

Name:	ilvH
Synonyms:	ilvN
Ordered Locus Names:	ML1695
ORF Names:	MLCB637.21

Organism

Mycobacterium leprae (strain TN) [Complete proteome] [HAMAP]

Taxonomic identifier

272631 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium leprae

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 pyruvate = 2-acetolactate + CO2.
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4. Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.
Subunit structure	Dimer of large and small chains By similarity.
Sequence similarities	Belongs to the acetolactate synthase small subunit family. Contains 1 ACT domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	isoleucine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway valine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	acetolactate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 169	169	Acetolactate synthase small subunit		PRO_0000151415
Regions
	Domain	7 – 80	74	ACT

Sequences

	Sequence		Length	Mass (Da)
	O33113 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: D450673379C88DD8	FASTA	169	18,284
	10 20 30 40 50 60 MVGLPTHTLS VLVEDTPGVL ARVAALFSRR GFNIESLAVG ATECKTMSRM TIVVSAEETP 70 80 90 100 110 120 LEQVTKQLHK LINVIKVVEQ EADNSLSREL ALIKVRAEAG TRSQVIEAVH LFRARVIDVS 130 140 150 160 LESLTVEATG DCSKIEALLR VLEPFGVREI VQSGVVSLSR GPRGIGTVR

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z99263 Genomic DNA. Translation: CAB16436.1. AL583923 Genomic DNA. Translation: CAC30648.1.
PIR	T45414.
RefSeq	NP_302165.1. NC_002677.1.
3D structure databases
ProteinModelPortal	O33113.
ModBase	Search...
Protein-protein interaction databases
STRING	272631.ML1695.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAC30648; CAC30648; CAC30648.
GeneID	910799.
KEGG	mle:ML1695.
PATRIC	18056538. VBIMycLep78757_3198.
Organism-specific databases
Leproma	ML1695.
CMR	Search...
Phylogenomic databases
eggNOG	COG0440.
HOGENOM	HOG000046747.
KO	K01653.
OMA	RMTIVVN.
ProtClustDB	PRK11895.
Enzyme and pathway databases
UniPathway	UPA00047; UER00055. UPA00049; UER00059.
Family and domain databases
InterPro	IPR004789. Acetalactate_synth_ssu. IPR019455. Acetolactate_synth_ssu_C. [Graphical view]
Pfam	PF10369. ALS_ss_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00119. acolac_sm. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVH_MYCLE

Accession

Primary (citable) accession number: O33113

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program