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O33113

- ILVH_MYCLE

UniProt

O33113 - ILVH_MYCLE

Protein

Acetolactate synthase small subunit

Gene

ilvH

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 pyruvate = 2-acetolactate + CO2.

    Pathwayi

    GO - Molecular functioni

    1. acetolactate synthase activity Source: UniProtKB-EC
    2. amino acid binding Source: InterPro

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
    2. valine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00047; UER00055.
    UPA00049; UER00059.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetolactate synthase small subunit (EC:2.2.1.6)
    Alternative name(s):
    Acetohydroxy-acid synthase small subunit
    Short name:
    AHAS
    Short name:
    ALS
    Gene namesi
    Name:ilvH
    Synonyms:ilvN
    Ordered Locus Names:ML1695
    ORF Names:MLCB637.21
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML1695.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 169169Acetolactate synthase small subunitPRO_0000151415Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer of large and small chains.By similarity

    Protein-protein interaction databases

    STRINGi272631.ML1695.

    Structurei

    3D structure databases

    ProteinModelPortaliO33113.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 8578ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ACT domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0440.
    HOGENOMiHOG000046747.
    KOiK01653.
    OMAiRGAKGWK.
    OrthoDBiEOG6X3W8W.

    Family and domain databases

    InterProiIPR004789. Acetalactate_synth_ssu.
    IPR019455. Acetolactate_synth_ssu_C.
    IPR002912. ACT_dom.
    [Graphical view]
    PfamiPF10369. ALS_ss_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00119. acolac_sm. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O33113-1 [UniParc]FASTAAdd to Basket

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    MVGLPTHTLS VLVEDTPGVL ARVAALFSRR GFNIESLAVG ATECKTMSRM    50
    TIVVSAEETP LEQVTKQLHK LINVIKVVEQ EADNSLSREL ALIKVRAEAG 100
    TRSQVIEAVH LFRARVIDVS LESLTVEATG DCSKIEALLR VLEPFGVREI 150
    VQSGVVSLSR GPRGIGTVR 169
    Length:169
    Mass (Da):18,284
    Last modified:January 1, 1998 - v1
    Checksum:iD450673379C88DD8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z99263 Genomic DNA. Translation: CAB16436.1.
    AL583923 Genomic DNA. Translation: CAC30648.1.
    PIRiT45414.
    RefSeqiNP_302165.1. NC_002677.1.
    WP_010908486.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC30648; CAC30648; CAC30648.
    GeneIDi910799.
    KEGGimle:ML1695.
    PATRICi18056538. VBIMycLep78757_3198.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z99263 Genomic DNA. Translation: CAB16436.1 .
    AL583923 Genomic DNA. Translation: CAC30648.1 .
    PIRi T45414.
    RefSeqi NP_302165.1. NC_002677.1.
    WP_010908486.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali O33113.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML1695.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC30648 ; CAC30648 ; CAC30648 .
    GeneIDi 910799.
    KEGGi mle:ML1695.
    PATRICi 18056538. VBIMycLep78757_3198.

    Organism-specific databases

    Lepromai ML1695.

    Phylogenomic databases

    eggNOGi COG0440.
    HOGENOMi HOG000046747.
    KOi K01653.
    OMAi RGAKGWK.
    OrthoDBi EOG6X3W8W.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00055 .
    UPA00049 ; UER00059 .

    Family and domain databases

    InterProi IPR004789. Acetalactate_synth_ssu.
    IPR019455. Acetolactate_synth_ssu_C.
    IPR002912. ACT_dom.
    [Graphical view ]
    Pfami PF10369. ALS_ss_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00119. acolac_sm. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiILVH_MYCLE
    AccessioniPrimary (citable) accession number: O33113
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3