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O33113

- ILVH_MYCLE

UniProt

O33113 - ILVH_MYCLE

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Protein

Acetolactate synthase small subunit

Gene

ilvH

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2 pyruvate = 2-acetolactate + CO2.

Pathwayi

GO - Molecular functioni

  1. acetolactate synthase activity Source: UniProtKB-EC
  2. amino acid binding Source: InterPro

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
  2. valine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00047; UER00055.
UPA00049; UER00059.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetolactate synthase small subunit (EC:2.2.1.6)
Alternative name(s):
Acetohydroxy-acid synthase small subunit
Short name:
AHAS
Short name:
ALS
Gene namesi
Name:ilvH
Synonyms:ilvN
Ordered Locus Names:ML1695
ORF Names:MLCB637.21
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1695.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169Acetolactate synthase small subunitPRO_0000151415Add
BLAST

Interactioni

Subunit structurei

Dimer of large and small chains.By similarity

Protein-protein interaction databases

STRINGi272631.ML1695.

Structurei

3D structure databases

ProteinModelPortaliO33113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8578ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ACT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0440.
HOGENOMiHOG000046747.
KOiK01653.
OMAiRGAKGWK.
OrthoDBiEOG6X3W8W.

Family and domain databases

InterProiIPR004789. Acetalactate_synth_ssu.
IPR019455. Acetolactate_synth_ssu_C.
IPR002912. ACT_dom.
[Graphical view]
PfamiPF10369. ALS_ss_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00119. acolac_sm. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33113-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGLPTHTLS VLVEDTPGVL ARVAALFSRR GFNIESLAVG ATECKTMSRM
60 70 80 90 100
TIVVSAEETP LEQVTKQLHK LINVIKVVEQ EADNSLSREL ALIKVRAEAG
110 120 130 140 150
TRSQVIEAVH LFRARVIDVS LESLTVEATG DCSKIEALLR VLEPFGVREI
160
VQSGVVSLSR GPRGIGTVR
Length:169
Mass (Da):18,284
Last modified:January 1, 1998 - v1
Checksum:iD450673379C88DD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99263 Genomic DNA. Translation: CAB16436.1.
AL583923 Genomic DNA. Translation: CAC30648.1.
PIRiT45414.
RefSeqiNP_302165.1. NC_002677.1.
WP_010908486.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30648; CAC30648; CAC30648.
GeneIDi910799.
KEGGimle:ML1695.
PATRICi18056538. VBIMycLep78757_3198.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99263 Genomic DNA. Translation: CAB16436.1 .
AL583923 Genomic DNA. Translation: CAC30648.1 .
PIRi T45414.
RefSeqi NP_302165.1. NC_002677.1.
WP_010908486.1. NC_002677.1.

3D structure databases

ProteinModelPortali O33113.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30648 ; CAC30648 ; CAC30648 .
GeneIDi 910799.
KEGGi mle:ML1695.
PATRICi 18056538. VBIMycLep78757_3198.

Organism-specific databases

Lepromai ML1695.

Phylogenomic databases

eggNOGi COG0440.
HOGENOMi HOG000046747.
KOi K01653.
OMAi RGAKGWK.
OrthoDBi EOG6X3W8W.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00055 .
UPA00049 ; UER00059 .

Family and domain databases

InterProi IPR004789. Acetalactate_synth_ssu.
IPR019455. Acetolactate_synth_ssu_C.
IPR002912. ACT_dom.
[Graphical view ]
Pfami PF10369. ALS_ss_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00119. acolac_sm. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiILVH_MYCLE
AccessioniPrimary (citable) accession number: O33113
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3