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Protein

Sensor-type histidine kinase PrrB

Gene

prrB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system PrrB/PrrA. Involved specifically in early intracellular multiplication of Mycobacterium. Probably phosphorylates PrrA (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor-type histidine kinase PrrB (EC:2.7.13.3)
Gene namesi
Name:prrB
Ordered Locus Names:ML2124
ORF Names:MLCB57.60c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2124.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000748531 – 446Sensor-type histidine kinase PrrBAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei240Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2124.

Structurei

3D structure databases

ProteinModelPortaliO33071.
SMRiO33071.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 222HAMPPROSITE-ProRule annotationAdd BLAST51
Domaini237 – 446Histidine kinasePROSITE-ProRule annotationAdd BLAST210

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 162Poly-Ala6

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108TAG. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000042110.
KOiK07655.
OMAiMEEGYAD.
OrthoDBiPOG091H02OU.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILSRIFAR TPSLRTRVVV ATAIGAAIPV LIVGTVVWVG ITNDRKERLD
60 70 80 90 100
RKLDEAAGFA IPFVPRGLDE IPRSPNDQDA IITVRRGNLV KSNFDITLPK
110 120 130 140 150
LTNDYADTYL RGVRYRVRTV EIPAPEPTSI AVGATYDATV AETNNLHRRV
160 170 180 190 200
LLICGFAIAA AAVFAWLLAA FAVRPFKQLA QQTRSVDAGG EAPRVEVHGA
210 220 230 240 250
TEAVEIAEAM RGMLQRIWNE QNRTKEALAS ARDFAAVSSH ELRTPLTAMR
260 270 280 290 300
TNLEVLATLD LADDQRKEVL GDVIRTQSRI EATLSALERL AQGELSTSDD
310 320 330 340 350
HVPVDITELL DRAAHDATRS YPELKVSLVP SPTCIIVGLP AGLRLAVDNA
360 370 380 390 400
VANAVKHGGA TRVQLSAVSS RAGVEIAVDD NGSGVPEDER QVVFERFSRG
410 420 430 440
STASHSGSGL GLALVAQQAQ LHGGTASLET SPLGGARLLL RISAPS
Length:446
Mass (Da):47,796
Last modified:January 1, 1998 - v1
Checksum:iC1F3F7AD8E07ED80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99494 Genomic DNA. Translation: CAB16700.1.
AL583924 Genomic DNA. Translation: CAC31079.1.
PIRiT45358.
RefSeqiNP_302403.1. NC_002677.1.
WP_010908723.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31079; CAC31079; CAC31079.
GeneIDi910405.
KEGGimle:ML2124.
PATRICi18058175. VBIMycLep78757_4010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99494 Genomic DNA. Translation: CAB16700.1.
AL583924 Genomic DNA. Translation: CAC31079.1.
PIRiT45358.
RefSeqiNP_302403.1. NC_002677.1.
WP_010908723.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO33071.
SMRiO33071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2124.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31079; CAC31079; CAC31079.
GeneIDi910405.
KEGGimle:ML2124.
PATRICi18058175. VBIMycLep78757_4010.

Organism-specific databases

LepromaiML2124.

Phylogenomic databases

eggNOGiENOG4108TAG. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000042110.
KOiK07655.
OMAiMEEGYAD.
OrthoDBiPOG091H02OU.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRRB_MYCLE
AccessioniPrimary (citable) accession number: O33071
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.