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Protein

Citrate synthase

Gene

gltA

Organism
Mycobacterium leprae
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase (gltA)
  2. no protein annotated in this organism
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei309 – 3091UniRule annotation
Active sitei366 – 3661UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthaseUniRule annotation
Gene namesi
Name:gltAImported
OrganismiMycobacterium lepraeImported
Taxonomic identifieri1769 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

Organism-specific databases

LepromaiML2130.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2130.

Structurei

3D structure databases

ProteinModelPortaliO33066.
SMRiO33066. Positions 5-431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZN. Bacteria.
COG0372. LUCA.
HOGENOMiHOG000021224.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTDDTVTL KYPGGEIDLQ IVRATEGNDG IAIVPVLAKT GYTTFDVGYG
60 70 80 90 100
NTASTKSSIT YIDGDAGILR YRGYPIEQLA EKSTFIEVCY LLIYGELPAT
110 120 130 140 150
DQLAEFTHRI QRHTMLHEDL KRFYDGFPRN AHPMPVLSSV VNALSAYYQD
160 170 180 190 200
ALDPMDNGQV ELSTIRLLAK LPTIAAYAYK KSVGQPFLYP DNAFSLVENF
210 220 230 240 250
LRMTFGLPAE PYEPDPEVVR ALDMLFILHA DHEQNCSTST VRLVGSSRAN
260 270 280 290 300
LFTSISGGIN ALWGPLHGGA NQAVLEMLEG IRESGDDVGG FVQKVKNCQA
310 320 330 340 350
GVKLMGFGHR VYKNYDPRAR IVKEQADKIL VKLGGDDDLL NIAKGLEEAA
360 370 380 390 400
LTDDYFIERK LYPNVDFYTG LIYRALGFPT RMFTVLFALG RLPGWIAHWR
410 420 430
EMHDEGDSKI GRPRQIYTGY TERDYTAIET R
Length:431
Mass (Da):48,112
Last modified:January 1, 1998 - v1
Checksum:i8C0BC2341145F48A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99494 Genomic DNA. Translation: CAB16687.1.
PIRiT45353.

Genome annotation databases

PATRICi18058209. VBIMycLep78757_4027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99494 Genomic DNA. Translation: CAB16687.1.
PIRiT45353.

3D structure databases

ProteinModelPortaliO33066.
SMRiO33066. Positions 5-431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2130.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

PATRICi18058209. VBIMycLep78757_4027.

Organism-specific databases

LepromaiML2130.

Phylogenomic databases

eggNOGiENOG4105BZN. Bacteria.
COG0372. LUCA.
HOGENOMiHOG000021224.

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Use of an ordered cosmid library to deduce the genomic organization of Mycobacterium leprae."
    Eiglmeier K., Honore N., Woods S.A., Caudron B., Cole S.T.
    Mol. Microbiol. 7:197-206(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Badcock K., Churcher C.M.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Parkhill J., Barrell B.G., Rajandream M.A.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO33066_MYCLR
AccessioniPrimary (citable) accession number: O33066
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 16, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.