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Protein

Probable ferredoxin/ferredoxin--NADP reductase

Gene

fprB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Iron-sulfur 1By similarity1
Metal bindingi15Iron-sulfur 1By similarity1
Metal bindingi19Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi46Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi49Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi52Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi56Iron-sulfur 1By similarity1
Binding sitei123FAD; via amide nitrogenBy similarity1
Binding sitei143FADBy similarity1
Binding sitei151FAD; via amide nitrogenBy similarity1
Binding sitei187FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei213NADPBy similarity1
Binding sitei314NADPBy similarity1
Binding sitei453FAD; via amide nitrogenBy similarity1
Binding sitei460NADP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi258 – 261NADPBy similarity4
Nucleotide bindingi302 – 303NADPBy similarity2
Nucleotide bindingi460 – 462FADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
Ligand4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, NADP

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-2337-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ferredoxin/ferredoxin--NADP reductase (EC:1.18.1.2)
Short name:
FNR
Gene namesi
Name:fprB
Ordered Locus Names:ML2134
ORF Names:MLCB57.39
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2134

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001676741 – 555Probable ferredoxin/ferredoxin--NADP reductaseAdd BLAST555

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2134

Structurei

3D structure databases

ProteinModelPortaliO33064
SMRiO33064
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 294Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST28
Domaini37 – 664Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 555Ferredoxin--NADP reductaseAdd BLAST441

Sequence similaritiesi

In the C-terminal section; belongs to the ferredoxin--NADP reductase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105EQH Bacteria
COG0493 LUCA
COG1146 LUCA
HOGENOMiHOG000249250
KOiK00528
OMAiVNCIHPS
OrthoDBiPOG091H007T

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR021163 Ferredox_Rdtase_adrenod
PfamiView protein in Pfam
PF00037 Fer4, 1 hit
PF07992 Pyr_redox_2, 1 hit
PIRSFiPIRSF000362 FNR, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits

Sequencei

Sequence statusi: Complete.

O33064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYIITQSCC NDGSCVFACP VNCIHPTPDE PGFATSEMLY IDPVACVDCG
60 70 80 90 100
ACVSACPVGA IASDTRLAPK QLPFIEINAS YYPARPIDLK LPPTSKLAPV
110 120 130 140 150
IPAAQVHVRR RPLTVAIVGS GPAAMYAADE LLTQPGVWVN VFEKLPTPYG
160 170 180 190 200
LVRAGLAPDH QNTKKVTELF DRVAEHRRFR FFLNVEIGRH LSHDELLAHH
210 220 230 240 250
HAVLYAVGAP DDRRLNIDGM GIPGTGTATE LVAWINAHPD FAYLPVDLSH
260 270 280 290 300
ERVVVIGNGN VALDVARLLT ADPDNLARTD ISEFALHVLG GSAVREVVVA
310 320 330 340 350
ARRGPAHSAF TLPELIGLKA TSEVVLDAGD RKLVEGDFAT VSDSLTRKKL
360 370 380 390 400
EVLSSLVDSS KPTSRRRIRL AYQLTPKRVL GNQRATGVEF SVTGTEESRR
410 420 430 440 450
FDAGLVLTSV GYRGKRIRDL PFDEEAAVIP NDGGRVVDPS RGRPMPGAYV
460 470 480 490 500
AGWIKRGPTG FIGTNKLCSV QTVQAVVADF NAGWLTDPVA EPAELAKLVH
510 520 530 540 550
ARQPDTVDSV GWRAIDAAEI AQGSTEGRPR RKFTDVADML AVAAGAPPLR

LRALS
Length:555
Mass (Da):59,712
Last modified:January 1, 1998 - v1
Checksum:i43C7292E6A2DFED9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99494 Genomic DNA Translation: CAB16679.1
AL583924 Genomic DNA Translation: CAC31089.1
PIRiT45351
RefSeqiNP_302407.1, NC_002677.1
WP_010908727.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC31089; CAC31089; CAC31089
GeneIDi909093
KEGGimle:ML2134
PATRICifig|272631.5.peg.4036

Similar proteinsi

Entry informationi

Entry nameiFPRB_MYCLE
AccessioniPrimary (citable) accession number: O33064
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health