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Protein

Probable ferredoxin/ferredoxin--NADP reductase

Gene

fprB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Iron-sulfur 1By similarity1
Metal bindingi15Iron-sulfur 1By similarity1
Metal bindingi19Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi46Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi49Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi52Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi56Iron-sulfur 1By similarity1
Binding sitei123FAD; via amide nitrogenBy similarity1
Binding sitei143FADBy similarity1
Binding sitei151FAD; via amide nitrogenBy similarity1
Binding sitei187FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei213NADPBy similarity1
Binding sitei314NADPBy similarity1
Binding sitei453FAD; via amide nitrogenBy similarity1
Binding sitei460NADP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi258 – 261NADPBy similarity4
Nucleotide bindingi302 – 303NADPBy similarity2
Nucleotide bindingi460 – 462FADBy similarity3

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ferredoxin/ferredoxin--NADP reductase (EC:1.18.1.2)
Short name:
FNR
Gene namesi
Name:fprB
Ordered Locus Names:ML2134
ORF Names:MLCB57.39
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001676741 – 555Probable ferredoxin/ferredoxin--NADP reductaseAdd BLAST555

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2134.

Structurei

3D structure databases

ProteinModelPortaliO33064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 294Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST28
Domaini37 – 664Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 555Ferredoxin--NADP reductaseAdd BLAST441

Sequence similaritiesi

In the C-terminal section; belongs to the ferredoxin--NADP reductase family.Curated
Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105EQH. Bacteria.
COG0493. LUCA.
COG1146. LUCA.
HOGENOMiHOG000249250.
KOiK00528.
OMAiCLNIFRR.
OrthoDBiPOG091H007T.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR023753. FAD/NAD-binding_dom.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYIITQSCC NDGSCVFACP VNCIHPTPDE PGFATSEMLY IDPVACVDCG
60 70 80 90 100
ACVSACPVGA IASDTRLAPK QLPFIEINAS YYPARPIDLK LPPTSKLAPV
110 120 130 140 150
IPAAQVHVRR RPLTVAIVGS GPAAMYAADE LLTQPGVWVN VFEKLPTPYG
160 170 180 190 200
LVRAGLAPDH QNTKKVTELF DRVAEHRRFR FFLNVEIGRH LSHDELLAHH
210 220 230 240 250
HAVLYAVGAP DDRRLNIDGM GIPGTGTATE LVAWINAHPD FAYLPVDLSH
260 270 280 290 300
ERVVVIGNGN VALDVARLLT ADPDNLARTD ISEFALHVLG GSAVREVVVA
310 320 330 340 350
ARRGPAHSAF TLPELIGLKA TSEVVLDAGD RKLVEGDFAT VSDSLTRKKL
360 370 380 390 400
EVLSSLVDSS KPTSRRRIRL AYQLTPKRVL GNQRATGVEF SVTGTEESRR
410 420 430 440 450
FDAGLVLTSV GYRGKRIRDL PFDEEAAVIP NDGGRVVDPS RGRPMPGAYV
460 470 480 490 500
AGWIKRGPTG FIGTNKLCSV QTVQAVVADF NAGWLTDPVA EPAELAKLVH
510 520 530 540 550
ARQPDTVDSV GWRAIDAAEI AQGSTEGRPR RKFTDVADML AVAAGAPPLR

LRALS
Length:555
Mass (Da):59,712
Last modified:January 1, 1998 - v1
Checksum:i43C7292E6A2DFED9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99494 Genomic DNA. Translation: CAB16679.1.
AL583924 Genomic DNA. Translation: CAC31089.1.
PIRiT45351.
RefSeqiNP_302407.1. NC_002677.1.
WP_010908727.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31089; CAC31089; CAC31089.
GeneIDi909093.
KEGGimle:ML2134.
PATRICi18058227. VBIMycLep78757_4036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99494 Genomic DNA. Translation: CAB16679.1.
AL583924 Genomic DNA. Translation: CAC31089.1.
PIRiT45351.
RefSeqiNP_302407.1. NC_002677.1.
WP_010908727.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO33064.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2134.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31089; CAC31089; CAC31089.
GeneIDi909093.
KEGGimle:ML2134.
PATRICi18058227. VBIMycLep78757_4036.

Organism-specific databases

LepromaiML2134.

Phylogenomic databases

eggNOGiENOG4105EQH. Bacteria.
COG0493. LUCA.
COG1146. LUCA.
HOGENOMiHOG000249250.
KOiK00528.
OMAiCLNIFRR.
OrthoDBiPOG091H007T.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR023753. FAD/NAD-binding_dom.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPRB_MYCLE
AccessioniPrimary (citable) accession number: O33064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.