Skip Header

Contribute Send feedback
Read comments (?) or add your own

O33064 (FPRB_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ferredoxin/ferredoxin--NADP reductase
Short name=FNR
EC=1.18.1.2
Gene names
Name:fprB
Ordered Locus Names:ML2134
ORF Names:MLCB57.39
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.

Cofactor

Binds 1 or 2 4Fe-4S clusters.

FAD.

Sequence similarities

In the C-terminal section; belongs to the ferredoxin--NADP reductase family.

Contains 2 4Fe-4S ferredoxin-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Probable ferredoxin/ferredoxin--NADP reductase
PRO_0000167674

Regions

Domain2 – 29284Fe-4S ferredoxin-type 1
Domain37 – 66304Fe-4S ferredoxin-type 2
Nucleotide binding258 – 2614NADP By similarity
Nucleotide binding302 – 3032NADP By similarity
Nucleotide binding460 – 4623FAD By similarity
Region115 – 555441Ferredoxin--NADP reductase

Sites

Metal binding91Iron-sulfur 1 By similarity
Metal binding151Iron-sulfur 1 By similarity
Metal binding191Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding461Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding491Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding521Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding561Iron-sulfur 1 By similarity
Binding site1231FAD; via amide nitrogen By similarity
Binding site1431FAD By similarity
Binding site1511FAD; via amide nitrogen By similarity
Binding site1871FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site2131NADP By similarity
Binding site3141NADP By similarity
Binding site4531FAD; via amide nitrogen By similarity
Binding site4601NADP; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
O33064 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 43C7292E6A2DFED9

FASTA55559,712
        10         20         30         40         50         60 
MPYIITQSCC NDGSCVFACP VNCIHPTPDE PGFATSEMLY IDPVACVDCG ACVSACPVGA 

        70         80         90        100        110        120 
IASDTRLAPK QLPFIEINAS YYPARPIDLK LPPTSKLAPV IPAAQVHVRR RPLTVAIVGS 

       130        140        150        160        170        180 
GPAAMYAADE LLTQPGVWVN VFEKLPTPYG LVRAGLAPDH QNTKKVTELF DRVAEHRRFR 

       190        200        210        220        230        240 
FFLNVEIGRH LSHDELLAHH HAVLYAVGAP DDRRLNIDGM GIPGTGTATE LVAWINAHPD 

       250        260        270        280        290        300 
FAYLPVDLSH ERVVVIGNGN VALDVARLLT ADPDNLARTD ISEFALHVLG GSAVREVVVA 

       310        320        330        340        350        360 
ARRGPAHSAF TLPELIGLKA TSEVVLDAGD RKLVEGDFAT VSDSLTRKKL EVLSSLVDSS 

       370        380        390        400        410        420 
KPTSRRRIRL AYQLTPKRVL GNQRATGVEF SVTGTEESRR FDAGLVLTSV GYRGKRIRDL 

       430        440        450        460        470        480 
PFDEEAAVIP NDGGRVVDPS RGRPMPGAYV AGWIKRGPTG FIGTNKLCSV QTVQAVVADF 

       490        500        510        520        530        540 
NAGWLTDPVA EPAELAKLVH ARQPDTVDSV GWRAIDAAEI AQGSTEGRPR RKFTDVADML 

       550 
AVAAGAPPLR LRALS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z99494 Genomic DNA. Translation: CAB16679.1.
AL583924 Genomic DNA. Translation: CAC31089.1.
PIRT45351.
RefSeqNP_302407.1. NC_002677.1.

3D structure databases

ProteinModelPortalO33064.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000029433; EBMYCP00000029039; EBMYCG00000029428.
GeneID909093.
GenomeReviewsGene locus ML2134 in contig AL450380_GR.
KEGGmle:ML2134.
NMPDRfig|272631.1.peg.1279.
PATRIC18058227. VBIMycLep78757_4036.

Organism-specific databases

LepromaML2134.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000014581.
HOGENOMHBG522200.
OMAAWINGHP.
ProtClustDBCLSK790809.

Enzyme and pathway databases

BioCycMLEP272631:ML2134-MONOMER.

Family and domain databases

InterProIPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR021163. Adrenodoxin_Rdtase.
IPR016040. NAD(P)-bd_dom.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00528.
PfamPF00037. Fer4. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PIRSFPIRSF000362. FNR. 1 hit.
PROSITEPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFPRB_MYCLE
AccessionPrimary (citable) accession number: O33064
Entry history
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: January 1, 1998
Last modified: January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents