O33039 (EFTS_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor Ts
Short name=EF-Ts

Gene names

Name:	tsf
Ordered Locus Names:	ML1597
ORF Names:	MLCB250.64

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. HAMAP MF_00050
Subcellular location	Cytoplasm HAMAP MF_00050.
Sequence similarities	Belongs to the EF-Ts family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Elongation factor Ts HAMAP MF_00050		PRO_0000161153
Regions
	Region	76 – 79	4	Involved in Mg(2+) ion dislocation from EF-Tu By similarity

Sequences

	Sequence		Length	Mass (Da)
	O33039 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 6FF0B37E5E5E1BD5	FASTA	276	29,156
	10 20 30 40 50 60 MANFTVADVK RLRALTGAGM LDCKSVLVET DGNFDKAVES LRIKGAKDVG KRAERATAEG 70 80 90 100 110 120 LVAAKDGALI ELNCETDFVA KNAEFQKLAN QIVGVVAAAK IVDVDALKGA SVGDKTVEQA 130 140 150 160 170 180 IAELAAKIGE KLKLRRAAIF NGTVATYLHK RAADLPPAVG VLVEYGAGTD AANSTAAAHA 190 200 210 220 230 240 AALQIAALKA RFLSRDDVPE DVLASERRIA EETAKAAGKP EQSLPKIVEG RLNGFFKDSV 250 260 270 LLEQPSVFDN KKTVKVLLDE AGVTVTRFVR FEVGQA

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z97369 Genomic DNA. Translation: CAB10658.1. AL583922 Genomic DNA. Translation: CAC30548.1.
PIR	G87108.
RefSeq	NP_302100.1. NC_002677.1.
3D structure databases
ProteinModelPortal	O33039.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000029476; EBMYCP00000029082; EBMYCG00000029471.
GeneID	909802.
GenomeReviews	Gene locus ML1597 in contig AL450380_GR.
KEGG	mle:ML1597.
NMPDR	fig|272631.1.peg.972.
PATRIC	18056156. VBIMycLep78757_3010.
Organism-specific databases
Leproma	ML1597.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016347.
HOGENOM	HBG713289.
OMA	YLHGTRI.
ProtClustDB	PRK09377.
Enzyme and pathway databases
BioCyc	MLEP272631:ML1597-MONOMER.
Family and domain databases
HAMAP	MF_00050. EF_Ts. [Tree]
InterPro	IPR001816. Transl_elong_EFTs/EF1B. IPR014039. Transl_elong_EFTs/EF1B_dimer. IPR018101. Transl_elong_Ts_CS. IPR009060. UBA-like. IPR000449. UBA/transl_elong_EF1B_N. [Graphical view]
Gene3D	G3DSA:3.30.479.20. Transl_elong_EFTs/EF1B_dimer. 3 hits.
KO	K02357.
PANTHER	PTHR11741. Transl_elong_EFTs/EF1B. 1 hit.
Pfam	PF00889. EF_TS. 1 hit. PF00627. UBA. 1 hit. [Graphical view]
SUPFAM	SSF54713. EF_TS. 1 hit. SSF46934. UBA_like. 1 hit.
TIGRFAMs	TIGR00116. Tsf. 1 hit.
PROSITE	PS01126. EF_TS_1. 1 hit. PS01127. EF_TS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFTS_MYCLE

Accession

Primary (citable) accession number: O33039

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program