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Protein

Probable signal peptidase I

Gene

lepB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841By similarity
Active sitei162 – 1621By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.024.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable signal peptidase I (EC:3.4.21.89)
Short name:
SPase I
Alternative name(s):
Leader peptidase I
Gene namesi
Name:lepB
Ordered Locus Names:ML1612
ORF Names:MLCB250.39
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1612.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5353CytoplasmicSequence analysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence analysisAdd
BLAST
Topological domaini75 – 289215ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Probable signal peptidase IPRO_0000109510Add
BLAST

Proteomic databases

PRIDEiO33021.

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1612.

Structurei

3D structure databases

ProteinModelPortaliO33021.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QYR. Bacteria.
COG0681. LUCA.
HOGENOMiHOG000003673.
KOiK03100.
OMAiVECCDDQ.
OrthoDBiPOG091H023R.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR019533. Peptidase_S26.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 3 hits.
PfamiPF00717. Peptidase_S24. 1 hit.
PF10502. Peptidase_S26. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 2 hits.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTETTDSVPE PPSDADQLQP KVSICGLDMP AEVSETAAEA AIGVSEPKKR
60 70 80 90 100
SALWEFAILA VIAIGLYYVM LTFVARPYLI PSESMEPTLH GCSGCVGDRI
110 120 130 140 150
MVDKITYRFS SPQPGDVIVF KGPPSWNTMY KSIRSNNIVL RSVQNALSFV
160 170 180 190 200
GFVPPDENDL VKRVIAVGGQ TVQCRSDTGL TVNGKPLKEP YLRPVTMNAD
210 220 230 240 250
LSFSPCLGSE FGPVTVPQGR LWVMGDNRIH SADSRYHCNS TDVVNGLSCT
260 270 280
GDPNSGTVPV SNVIGKARVV VWPPSRWGGV GSVNSQQGQ
Length:289
Mass (Da):31,086
Last modified:January 1, 1998 - v1
Checksum:i69F59B03944768DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97369 Genomic DNA. Translation: CAB10633.1.
AL583922 Genomic DNA. Translation: CAC30563.1.
PIRiF87110.
RefSeqiNP_302111.1. NC_002677.1.
WP_010908432.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30563; CAC30563; CAC30563.
GeneIDi909308.
KEGGimle:ML1612.
PATRICi18056212. VBIMycLep78757_3038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97369 Genomic DNA. Translation: CAB10633.1.
AL583922 Genomic DNA. Translation: CAC30563.1.
PIRiF87110.
RefSeqiNP_302111.1. NC_002677.1.
WP_010908432.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO33021.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1612.

Protein family/group databases

MEROPSiS26.024.

Proteomic databases

PRIDEiO33021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30563; CAC30563; CAC30563.
GeneIDi909308.
KEGGimle:ML1612.
PATRICi18056212. VBIMycLep78757_3038.

Organism-specific databases

LepromaiML1612.

Phylogenomic databases

eggNOGiENOG4107QYR. Bacteria.
COG0681. LUCA.
HOGENOMiHOG000003673.
KOiK03100.
OMAiVECCDDQ.
OrthoDBiPOG091H023R.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR019533. Peptidase_S26.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 3 hits.
PfamiPF00717. Peptidase_S24. 1 hit.
PF10502. Peptidase_S26. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 2 hits.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEP_MYCLE
AccessioniPrimary (citable) accession number: O33021
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.