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Protein

Chaperone protein HtpG

Gene

htpG

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Molecular chaperone. Has ATPase activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1775-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein HtpGUniRule annotation
Alternative name(s):
Heat shock protein HtpGUniRule annotation
High temperature protein GUniRule annotation
Gene namesi
Name:htpGUniRule annotation
Ordered Locus Names:ML1623
ORF Names:MLCB250.19c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1623

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000629941 – 656Chaperone protein HtpGAdd BLAST656

Proteomic databases

PRIDEiO33012

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi272631.ML1623

Structurei

3D structure databases

ProteinModelPortaliO33012
SMRiO33012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 359A; substrate-bindingUniRule annotationAdd BLAST359
Regioni360 – 575BUniRule annotationAdd BLAST216
Regioni576 – 656CUniRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the heat shock protein 90 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJX Bacteria
COG0326 LUCA
HOGENOMiHOG000031989
KOiK04079
OMAiSDHEIFL
OrthoDBiPOG091H05QK

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit

Sequencei

Sequence statusi: Complete.

O33012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQVEQLEF QAEARQLLDL MVHSVYSNKD AFLRELISNA SDALDKLRLE
60 70 80 90 100
AFRNKDLDPR TVDTSDLHIE IEVDKNTRIL TVRDNGIGMT RAEVVDLIGT
110 120 130 140 150
LAKSGTAKLR QKLHAAKNLK DTAASEGLIG QFGIGFYSSF MVANKVELLT
160 170 180 190 200
RKAGETAATR WSSDGEATYT IESVDEAPQG TSVTLHLKPE DFEDELHDYT
210 220 230 240 250
SEWKIRELVK KYSDFIAWPI RMEVERRAPA TSDGEGADGE EQVTIETQTI
260 270 280 290 300
NSMKALWTKS KDEVSEDEYK EFYKHIAHAW DDPLEVIAMK AEGTFEYQAL
310 320 330 340 350
LFIPSHAPFD LFNSDAKIGM QLYVKRVFIM SDCDQLMPMY LRFVKGVVDA
360 370 380 390 400
EDMSLNVSRE ILQQNRQINA IRRRLTKKVL SAIKDLQAER PQDYRTFWTQ
410 420 430 440 450
FGKVLKEGLM SDSDNRDTLL HISSFASTHS DEEPTTLAQY VERMKDGQDQ
460 470 480 490 500
IFYATGESRQ QVMNSPHLEA FKAKGYEVLL LTDPVDEVWV GMAPEFDGKP
510 520 530 540 550
LKSVARGEVD LESEEEKTAH EAERKEQEQN FAGLVNWLKE TLSDHVKEVR
560 570 580 590 600
LSTRLTESPA CLITDAFGIT PALARIYRAS GQDVPFGKRI LELNPNHPLI
610 620 630 640 650
TGLQQAHENG GDDTHLRQLS ETAELLYGTA LLAEGGALEN PAKFAGLLAD

LLSRSM
Length:656
Mass (Da):73,866
Last modified:January 1, 1998 - v1
Checksum:iA526690CA66E03FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97369 Genomic DNA Translation: CAB10613.1
AL583922 Genomic DNA Translation: CAC30574.1
PIRiA87112
RefSeqiNP_302118.1, NC_002677.1
WP_010908439.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30574; CAC30574; CAC30574
GeneIDi909831
KEGGimle:ML1623
PATRICifig|272631.5.peg.3058

Similar proteinsi

Entry informationi

Entry nameiHTPG_MYCLE
AccessioniPrimary (citable) accession number: O33012
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health