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Protein

Chaperone protein HtpG

Gene

htpG

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Molecular chaperone. Has ATPase activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein HtpGUniRule annotation
Alternative name(s):
Heat shock protein HtpGUniRule annotation
High temperature protein GUniRule annotation
Gene namesi
Name:htpGUniRule annotation
Ordered Locus Names:ML1623
ORF Names:MLCB250.19c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1623.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000629941 – 656Chaperone protein HtpGAdd BLAST656

Proteomic databases

PRIDEiO33012.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1623.

Structurei

3D structure databases

ProteinModelPortaliO33012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 359A; substrate-bindingUniRule annotationAdd BLAST359
Regioni360 – 575BUniRule annotationAdd BLAST216
Regioni576 – 656CUniRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the heat shock protein 90 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJX. Bacteria.
COG0326. LUCA.
HOGENOMiHOG000031989.
KOiK04079.
OMAiYLRFMRG.
OrthoDBiPOG091H05QK.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQVEQLEF QAEARQLLDL MVHSVYSNKD AFLRELISNA SDALDKLRLE
60 70 80 90 100
AFRNKDLDPR TVDTSDLHIE IEVDKNTRIL TVRDNGIGMT RAEVVDLIGT
110 120 130 140 150
LAKSGTAKLR QKLHAAKNLK DTAASEGLIG QFGIGFYSSF MVANKVELLT
160 170 180 190 200
RKAGETAATR WSSDGEATYT IESVDEAPQG TSVTLHLKPE DFEDELHDYT
210 220 230 240 250
SEWKIRELVK KYSDFIAWPI RMEVERRAPA TSDGEGADGE EQVTIETQTI
260 270 280 290 300
NSMKALWTKS KDEVSEDEYK EFYKHIAHAW DDPLEVIAMK AEGTFEYQAL
310 320 330 340 350
LFIPSHAPFD LFNSDAKIGM QLYVKRVFIM SDCDQLMPMY LRFVKGVVDA
360 370 380 390 400
EDMSLNVSRE ILQQNRQINA IRRRLTKKVL SAIKDLQAER PQDYRTFWTQ
410 420 430 440 450
FGKVLKEGLM SDSDNRDTLL HISSFASTHS DEEPTTLAQY VERMKDGQDQ
460 470 480 490 500
IFYATGESRQ QVMNSPHLEA FKAKGYEVLL LTDPVDEVWV GMAPEFDGKP
510 520 530 540 550
LKSVARGEVD LESEEEKTAH EAERKEQEQN FAGLVNWLKE TLSDHVKEVR
560 570 580 590 600
LSTRLTESPA CLITDAFGIT PALARIYRAS GQDVPFGKRI LELNPNHPLI
610 620 630 640 650
TGLQQAHENG GDDTHLRQLS ETAELLYGTA LLAEGGALEN PAKFAGLLAD

LLSRSM
Length:656
Mass (Da):73,866
Last modified:January 1, 1998 - v1
Checksum:iA526690CA66E03FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97369 Genomic DNA. Translation: CAB10613.1.
AL583922 Genomic DNA. Translation: CAC30574.1.
PIRiA87112.
RefSeqiNP_302118.1. NC_002677.1.
WP_010908439.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30574; CAC30574; CAC30574.
GeneIDi909831.
KEGGimle:ML1623.
PATRICi18056252. VBIMycLep78757_3058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97369 Genomic DNA. Translation: CAB10613.1.
AL583922 Genomic DNA. Translation: CAC30574.1.
PIRiA87112.
RefSeqiNP_302118.1. NC_002677.1.
WP_010908439.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO33012.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1623.

Proteomic databases

PRIDEiO33012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30574; CAC30574; CAC30574.
GeneIDi909831.
KEGGimle:ML1623.
PATRICi18056252. VBIMycLep78757_3058.

Organism-specific databases

LepromaiML1623.

Phylogenomic databases

eggNOGiENOG4105CJX. Bacteria.
COG0326. LUCA.
HOGENOMiHOG000031989.
KOiK04079.
OMAiYLRFMRG.
OrthoDBiPOG091H05QK.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHTPG_MYCLE
AccessioniPrimary (citable) accession number: O33012
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.