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Protein

Methionine aminopeptidase

Gene

map

Organism
Mycobacterium leprae
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88SubstrateUniRule annotation1
Metal bindingi106Divalent metal cation 1UniRule annotation1
Metal bindingi117Divalent metal cation 1UniRule annotation1
Metal bindingi117Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi186Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation1
Binding sitei193SubstrateUniRule annotation1
Metal bindingi219Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi250Divalent metal cation 1UniRule annotation1
Metal bindingi250Divalent metal cation 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseUniRule annotationImported, Hydrolase, Protease
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidaseUniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAPUniRule annotation
Short name:
MetAPUniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
Name:mapUniRule annotationImported
OrganismiMycobacterium lepraeImported
Taxonomic identifieri1769 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

Organism-specific databases

LepromaiML1831.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO33008.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 257Peptidase_M24InterPro annotationAdd BLAST235

Phylogenomic databases

eggNOGiENOG4105CA1. Bacteria.
COG0024. LUCA.
HOGENOMiHOG000030426.

Family and domain databases

CDDicd01086. MetAP1. 1 hit.
HAMAPiMF_01974. MetAP_1. 1 hit.
InterProiView protein in InterPro
IPR036005. Creatinase/aminopeptidase-like.
IPR000994. Pept_M24.
IPR001714. Pept_M24_MAP.
IPR002467. Pept_M24A_MAP1.
PfamiView protein in Pfam
PF00557. Peptidase_M24. 1 hit.
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 1 hit.
TIGRFAMsiTIGR00500. met_pdase_I. 1 hit.

Sequencei

Sequence statusi: Complete.

O33008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALTRLRSR RVVPQRSVGE LDAMAAAGAV VAAALHAVRD AAGPGVSSLS
60 70 80 90 100
LDEIAESVIR EAGATPSFLR YHGYPATICT SVNDRVIHGI PSAVEILAPG
110 120 130 140 150
DLVSIDCGAV LDGWHGDAAI TFGVGTLTSV DEALSQATRE SLEAGIAAMI
160 170 180 190 200
VNNRLTDVAH AIEVSTRTSE IRYRLTFGIV QGYGGHGIGR HMHMDPFLPN
210 220 230 240 250
EGAPGRGPLL VPGSVLAIEP MLTLGTGKTI VLDDEWTVTT ADGSRAAHWE
260
HTVAVTEDGP RVLTLA
Length:266
Mass (Da):27,738
Last modified:January 1, 1998 - v1
Checksum:i50EE74D0BFAA80DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98756 Genomic DNA. Translation: CAB11461.1.
PIRiT45391.

Similar proteinsi

Entry informationi

Entry nameiO33008_MYCLR
AccessioniPrimary (citable) accession number: O33008
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)