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Protein

Adenylate kinase

Gene

adk

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from ADP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenylate kinase (adk)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from ADP, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311AMPUniRule annotation
Binding sitei36 – 361AMPUniRule annotation
Binding sitei92 – 921AMPUniRule annotation
Binding sitei127 – 1271ATPUniRule annotation
Binding sitei129 – 1291AMPUniRule annotation
Binding sitei140 – 1401AMPUniRule annotation
Binding sitei166 – 1661ATP; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156ATPUniRule annotation
Nucleotide bindingi57 – 593AMPUniRule annotation
Nucleotide bindingi85 – 884AMPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00588; UER00649.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinaseUniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AKUniRule annotation
Alternative name(s):
ATP-AMP transphosphorylaseUniRule annotation
ATP:AMP phosphotransferaseUniRule annotation
Adenylate monophosphate kinaseUniRule annotation
Gene namesi
Name:adkUniRule annotation
Ordered Locus Names:ML1832
ORF Names:MLCB2492.28
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1832.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Adenylate kinasePRO_0000158799Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1832.

Structurei

3D structure databases

ProteinModelPortaliO33007.
SMRiO33007. Positions 1-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 5930NMPbindUniRule annotationAdd
BLAST
Regioni126 – 1327LIDUniRule annotation

Domaini

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.UniRule annotation

Sequence similaritiesi

Belongs to the adenylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CC8. Bacteria.
COG0563. LUCA.
HOGENOMiHOG000238772.
KOiK00939.
OMAiRWVCRSC.
OrthoDBiEOG679TH4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00235. Adenylate_kinase_Adk.
InterProiIPR006259. Adenyl_kin_sub.
IPR000850. Adenylat/UMP-CMP_kin.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23359. PTHR23359. 1 hit.
PRINTSiPR00094. ADENYLTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01351. adk. 1 hit.
PROSITEiPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33007-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVVLLGPPG AGKGTQAQRL AEKLGIPQIS TGELFRRNIE KDTKLGHEAK
60 70 80 90 100
KYLDAGDLVP ADLTNQLVDD RLNKSDTVDG FILDGYPRSL EQAKALHEML
110 120 130 140 150
ERRGTDIDAV LEFRVSQAVV LERLKGRGRA DDTDDVVINR MNIYRDETAS
160 170 180
LLEYYSSELK TIDAIGTMDE VFARALHALG K
Length:181
Mass (Da):20,111
Last modified:April 27, 2001 - v2
Checksum:i3023A5EFC359A614
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491A → R in CAB11460 (PubMed:11234002).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98756 Genomic DNA. Translation: CAB11460.1.
AL583923 Genomic DNA. Translation: CAC30786.1.
PIRiB87138.
T45390.
RefSeqiNP_302242.1. NC_002677.1.
WP_010908563.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30786; CAC30786; CAC30786.
GeneIDi910658.
KEGGimle:ML1832.
PATRICi18057098. VBIMycLep78757_3476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98756 Genomic DNA. Translation: CAB11460.1.
AL583923 Genomic DNA. Translation: CAC30786.1.
PIRiB87138.
T45390.
RefSeqiNP_302242.1. NC_002677.1.
WP_010908563.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO33007.
SMRiO33007. Positions 1-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1832.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30786; CAC30786; CAC30786.
GeneIDi910658.
KEGGimle:ML1832.
PATRICi18057098. VBIMycLep78757_3476.

Organism-specific databases

LepromaiML1832.

Phylogenomic databases

eggNOGiENOG4105CC8. Bacteria.
COG0563. LUCA.
HOGENOMiHOG000238772.
KOiK00939.
OMAiRWVCRSC.
OrthoDBiEOG679TH4.

Enzyme and pathway databases

UniPathwayiUPA00588; UER00649.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00235. Adenylate_kinase_Adk.
InterProiIPR006259. Adenyl_kin_sub.
IPR000850. Adenylat/UMP-CMP_kin.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23359. PTHR23359. 1 hit.
PRINTSiPR00094. ADENYLTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01351. adk. 1 hit.
PROSITEiPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiKAD_MYCLE
AccessioniPrimary (citable) accession number: O33007
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 27, 2001
Last modified: July 6, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.