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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-2012-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotation
Ordered Locus Names:ML1833
ORF Names:MLCB2492.27
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1833

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalUniRule annotationAdd BLAST21
Transmembranei76 – 96HelicalUniRule annotationAdd BLAST21
Transmembranei121 – 141HelicalUniRule annotationAdd BLAST21
Transmembranei154 – 174HelicalUniRule annotationAdd BLAST21
Transmembranei177 – 197HelicalUniRule annotationAdd BLAST21
Transmembranei212 – 232HelicalUniRule annotationAdd BLAST21
Transmembranei269 – 289HelicalUniRule annotationAdd BLAST21
Transmembranei315 – 335HelicalUniRule annotationAdd BLAST21
Transmembranei375 – 395HelicalUniRule annotationAdd BLAST21
Transmembranei398 – 418HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001317311 – 438Protein translocase subunit SecYAdd BLAST438

Proteomic databases

PRIDEiO33006

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1833

Structurei

3D structure databases

ProteinModelPortaliO33006
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CGG Bacteria
COG0201 LUCA
HOGENOMiHOG000080586
KOiK03076
OMAiQTYVISQ
OrthoDBiPOG091H024M

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
HAMAPiMF_01465 SecY, 1 hit
InterProiView protein in InterPro
IPR026593 SecY
IPR002208 SecY/SEC61-alpha
IPR030659 SecY_CS
IPR023201 SecY_dom_sf
PANTHERiPTHR10906 PTHR10906, 1 hit
PfamiView protein in Pfam
PF00344 SecY, 1 hit
PIRSFiPIRSF004557 SecY, 1 hit
SUPFAMiSSF103491 SSF103491, 1 hit
TIGRFAMsiTIGR00967 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755 SECY_1, 1 hit
PS00756 SECY_2, 1 hit

Sequencei

Sequence statusi: Complete.

O33006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAFISSLR TVDLRRKILF TLGILVLYRV SAALPSPGVN YRHVQQCIQE
60 70 80 90 100
ATAGEAGEIY SLINLFSGGA LLKLTVGVMP YITASIIVQL LTVVIPRFEE
110 120 130 140 150
LRKEGQAGQA KMTQYTRYLA IALAVLQATS IVALAANGGL LQGCQEDIIS
160 170 180 190 200
DQSIFSLVVI VLVMTGGAAL VMWMGELITE RGIGNGMSLL IFVGIAARIP
210 220 230 240 250
AEGKQILDSR GGVIFAAVCL AALVIIVGVV FVEQGQRRIP VQYAKRMVGR
260 270 280 290 300
RMYGGTSTYL PLKVNQAGVI PVIFASSLIY IPHLITQLVR SGSGGVGKSW
310 320 330 340 350
WDKFVGTYLS DPADPVYINI YFGLIIFFTY FYVSVTFNPD ERADEMKKFG
360 370 380 390 400
GFIPGIRPGR PTADYLRYVL SRITLPGSIY LGAIAVLPNL FLQIGNGGEV
410 420 430
QNLPFGGTAV LIMIGVGLDT VKQIESQLMQ RNYEGFLK
Length:438
Mass (Da):47,518
Last modified:January 1, 1998 - v1
Checksum:i285B13BCE2C8EE20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98756 Genomic DNA Translation: CAB11459.1
AL583923 Genomic DNA Translation: CAC30787.1
PIRiT45389
RefSeqiNP_302243.1, NC_002677.1
WP_010908564.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30787; CAC30787; CAC30787
GeneIDi910657
KEGGimle:ML1833
PATRICifig|272631.5.peg.3477

Similar proteinsi

Entry informationi

Entry nameiSECY_MYCLE
AccessioniPrimary (citable) accession number: O33006
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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