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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotation
Ordered Locus Names:ML1833
ORF Names:MLCB2492.27
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1833.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalUniRule annotationAdd
BLAST
Transmembranei76 – 9621HelicalUniRule annotationAdd
BLAST
Transmembranei121 – 14121HelicalUniRule annotationAdd
BLAST
Transmembranei154 – 17421HelicalUniRule annotationAdd
BLAST
Transmembranei177 – 19721HelicalUniRule annotationAdd
BLAST
Transmembranei212 – 23221HelicalUniRule annotationAdd
BLAST
Transmembranei269 – 28921HelicalUniRule annotationAdd
BLAST
Transmembranei315 – 33521HelicalUniRule annotationAdd
BLAST
Transmembranei375 – 39521HelicalUniRule annotationAdd
BLAST
Transmembranei398 – 41821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Protein translocase subunit SecYPRO_0000131731Add
BLAST

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1833.

Structurei

3D structure databases

ProteinModelPortaliO33006.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080586.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiEOG651SWP.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O33006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAFISSLR TVDLRRKILF TLGILVLYRV SAALPSPGVN YRHVQQCIQE
60 70 80 90 100
ATAGEAGEIY SLINLFSGGA LLKLTVGVMP YITASIIVQL LTVVIPRFEE
110 120 130 140 150
LRKEGQAGQA KMTQYTRYLA IALAVLQATS IVALAANGGL LQGCQEDIIS
160 170 180 190 200
DQSIFSLVVI VLVMTGGAAL VMWMGELITE RGIGNGMSLL IFVGIAARIP
210 220 230 240 250
AEGKQILDSR GGVIFAAVCL AALVIIVGVV FVEQGQRRIP VQYAKRMVGR
260 270 280 290 300
RMYGGTSTYL PLKVNQAGVI PVIFASSLIY IPHLITQLVR SGSGGVGKSW
310 320 330 340 350
WDKFVGTYLS DPADPVYINI YFGLIIFFTY FYVSVTFNPD ERADEMKKFG
360 370 380 390 400
GFIPGIRPGR PTADYLRYVL SRITLPGSIY LGAIAVLPNL FLQIGNGGEV
410 420 430
QNLPFGGTAV LIMIGVGLDT VKQIESQLMQ RNYEGFLK
Length:438
Mass (Da):47,518
Last modified:January 1, 1998 - v1
Checksum:i285B13BCE2C8EE20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98756 Genomic DNA. Translation: CAB11459.1.
AL583923 Genomic DNA. Translation: CAC30787.1.
PIRiT45389.
RefSeqiNP_302243.1. NC_002677.1.
WP_010908564.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30787; CAC30787; CAC30787.
GeneIDi910657.
KEGGimle:ML1833.
PATRICi18057100. VBIMycLep78757_3477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98756 Genomic DNA. Translation: CAB11459.1.
AL583923 Genomic DNA. Translation: CAC30787.1.
PIRiT45389.
RefSeqiNP_302243.1. NC_002677.1.
WP_010908564.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO33006.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30787; CAC30787; CAC30787.
GeneIDi910657.
KEGGimle:ML1833.
PATRICi18057100. VBIMycLep78757_3477.

Organism-specific databases

LepromaiML1833.

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080586.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiEOG651SWP.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiSECY_MYCLE
AccessioniPrimary (citable) accession number: O33006
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: January 1, 1998
Last modified: November 11, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.