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Protein

Probable branched-chain-amino-acid aminotransferase

Gene

ilvE

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts on leucine, isoleucine and valine.By similarity

Catalytic activityi

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.

Cofactori

Pathwayi: L-isoleucine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-isoleucine from 2-oxobutanoate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase small subunit (ilvH), Acetolactate synthase (ilvB)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Probable branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-isoleucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-isoleucine from 2-oxobutanoate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-leucine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. 2-isopropylmalate synthase (leuA)
  2. 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase large subunit (leuC)
  3. 3-isopropylmalate dehydrogenase (leuB)
  4. Probable branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-leucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate, the pathway L-leucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-valine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-valine from pyruvate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase small subunit (ilvH), Acetolactate synthase (ilvB)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Probable branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-valine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-valine from pyruvate, the pathway L-valine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-943-MONOMER
UniPathwayiUPA00047; UER00058
UPA00048; UER00073
UPA00049; UER00062

Names & Taxonomyi

Protein namesi
Recommended name:
Probable branched-chain-amino-acid aminotransferase (EC:2.6.1.42)
Short name:
BCAT
Gene namesi
Name:ilvE
Ordered Locus Names:ML0866
ORF Names:MLCB22.12c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0866

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001032731 – 368Probable branched-chain-amino-acid aminotransferaseAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiO32954

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0866

Structurei

3D structure databases

ProteinModelPortaliO32954
SMRiO32954
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CM2 Bacteria
COG0115 LUCA
HOGENOMiHOG000276704
KOiK00826
OMAiNFFGITH
OrthoDBiPOG091H02MO

Family and domain databases

CDDicd01557 BCAT_beta_family, 1 hit
InterProiView protein in InterPro
IPR001544 Aminotrans_IV
IPR018300 Aminotrans_IV_CS
IPR036038 Aminotransferase-like
IPR005786 B_amino_transII
IPR033939 BCAT_family
PfamiView protein in Pfam
PF01063 Aminotran_4, 1 hit
PIRSFiPIRSF006468 BCAT1, 1 hit
SUPFAMiSSF56752 SSF56752, 1 hit
TIGRFAMsiTIGR01123 ilvE_II, 1 hit
PROSITEiView protein in PROSITE
PS00770 AA_TRANSFER_CLASS_4, 1 hit

Sequencei

Sequence statusi: Complete.

O32954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGFLEFTV SLSAHPVTDA ERESILAEPG FGKYHTDHMV SIDYIDGRGW
60 70 80 90 100
HDARVIPYGP IQLDPSAIVL HYAQEVFEGL KAYRWADGSI VSFRPDANAA
110 120 130 140 150
RLRSSARRIA IPELPDELFI DSLCQLIAVD NAWVPRVGGE EALYLRPFIF
160 170 180 190 200
ATEPGLGVRP AKQYRYLLIA SPVGAYFKGG INPVTVWVSM EYVRASPGGT
210 220 230 240 250
GAAKFGGNYA ASLLAQTEAA ANGCDQVVWL DAVERRFVEE MGGMNIFFVL
260 270 280 290 300
GSGGSARLVT PELSGSLLPG VTRASLLQLA IDAGFSVEER KIDIDEWQKK
310 320 330 340 350
AAAGEITEVF ACGTAAFITP VSRVKYGDTE FTIAGGAPGE VTMALRDTLT
360
GIQRGTFADT HGWMARLG
Length:368
Mass (Da):39,715
Last modified:January 1, 1998 - v1
Checksum:iAD466EE985F5505A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98741 Genomic DNA Translation: CAB11377.1
AL583920 Genomic DNA Translation: CAC31247.1
PIRiT44887
RefSeqiNP_301654.1, NC_002677.1
WP_010907978.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC31247; CAC31247; CAC31247
GeneIDi909864
KEGGimle:ML0866
PATRICifig|272631.5.peg.1593

Similar proteinsi

Entry informationi

Entry nameiILVE_MYCLE
AccessioniPrimary (citable) accession number: O32954
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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