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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).By similarity

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.

Pathwayi: alpha-ribazole biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
  2. no protein annotated in this organism
This subpathway is part of the pathway alpha-ribazole biosynthesis, which is itself part of Nucleoside biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei313Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00061; UER00516.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC:2.4.2.21)
Short name:
NN:DBI PRT
Alternative name(s):
N(1)-alpha-phosphoribosyltransferase
Gene namesi
Name:cobT
Ordered Locus Names:ML0868
ORF Names:MLCB22.08
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0868.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001670551 – 351Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseAdd BLAST351

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0868.

Structurei

3D structure databases

ProteinModelPortaliO32953.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.Curated

Phylogenomic databases

eggNOGiCOG2038. LUCA.
HOGENOMiHOG000263500.
KOiK00768.
OMAiATFGGFE.
OrthoDBiPOG091H0031.

Family and domain databases

CDDicd02439. DMB-PRT_CobT. 1 hit.
Gene3Di1.10.1610.10. 1 hit.
HAMAPiMF_00230. CobT. 1 hit.
InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamiPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMiSSF52733. SSF52733. 1 hit.
TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.

Sequencei

Sequence statusi: Complete.

O32953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFAPVSPPD GHAAAAARAR QDTLTKPRGA LGRLEDLSIW VASCQGQCPP
60 70 80 90 100
RQFQRARIVV FAGDHGVARS GVSAYPPQLT AQMVANIDRG GAAINALASI
110 120 130 140 150
ADATIRIADL AVDADPLSQQ IGIHKVRRGS GDIAIQDALT EDETARAIIA
160 170 180 190 200
GQRIADEEVD RGADLLIAGD IGIGNTTAAA VLVAALTNAE PVAVVGFGTG
210 220 230 240 250
IDDASWARKT AAVRDALCRI RLVLPDPVGL LRCCGGADLA AMAGFCAQAA
260 270 280 290 300
VRRTPLLLDG MVVTAAALVA ERLAPGSWQW WQAGHQSTEP GHALALAALD
310 320 330 340 350
LDPILDLRMR LGEGTGATAA LLVLRAAVAA LTSMTTFAEA GVAGTSTSPP

S
Length:351
Mass (Da):36,017
Last modified:January 1, 1998 - v1
Checksum:i919231520D5FE2A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98741 Genomic DNA. Translation: CAB11373.1.
AL583920 Genomic DNA. Translation: CAC31249.1.
PIRiT44886.
RefSeqiNP_301655.1. NC_002677.1.
WP_010907979.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31249; CAC31249; CAC31249.
GeneIDi909862.
KEGGimle:ML0868.
PATRICi18053304. VBIMycLep78757_1597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98741 Genomic DNA. Translation: CAB11373.1.
AL583920 Genomic DNA. Translation: CAC31249.1.
PIRiT44886.
RefSeqiNP_301655.1. NC_002677.1.
WP_010907979.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO32953.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0868.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31249; CAC31249; CAC31249.
GeneIDi909862.
KEGGimle:ML0868.
PATRICi18053304. VBIMycLep78757_1597.

Organism-specific databases

LepromaiML0868.

Phylogenomic databases

eggNOGiCOG2038. LUCA.
HOGENOMiHOG000263500.
KOiK00768.
OMAiATFGGFE.
OrthoDBiPOG091H0031.

Enzyme and pathway databases

UniPathwayiUPA00061; UER00516.

Family and domain databases

CDDicd02439. DMB-PRT_CobT. 1 hit.
Gene3Di1.10.1610.10. 1 hit.
HAMAPiMF_00230. CobT. 1 hit.
InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamiPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMiSSF52733. SSF52733. 1 hit.
TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOBT_MYCLE
AccessioniPrimary (citable) accession number: O32953
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.