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O32915 (GCSP_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Synonyms:gcvB
Ordered Locus Names:ML2072
ORF Names:MLCB1788.32c
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length952 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 952952Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166919

Amino acid modifications

Modified residue7031N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
O32915 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: ADC68B6265C3D8FF

FASTA952101,283
        10         20         30         40         50         60 
MSVPNSSNKQ TCFTARHIGP NSEDVATMLA VIGVESLDDL AAKAVPSDIL DNVTDTGVAP 

        70         80         90        100        110        120 
GLDRLPPPAT ESETLAELGA LARANTVAVS MIGQGYYDTL TPAVLSRNIL ENPAWYTPYT 

       130        140        150        160        170        180 
PYQPEISQGR LEALLNFQTL VSDLTGLEIA NASMLDEGTA AAEAMTLMYR AARSTASRVV 

       190        200        210        220        230        240 
VDVDVFAQTV AVFATRAKPL GIDIVVADLR EGLPDGEFFG VITQLPGASG RITDWTALIA 

       250        260        270        280        290        300 
QAHSRGALVA VGADLLALTL ITPPGEIGAD VAFGTTQRFG VPMGFGGPHA GYLALHTKHA 

       310        320        330        340        350        360 
RQLPGRLVGV SVDSDGTPAY RLALQTREQH IRRDKATSNI CTAQVLLAVM AAMYASYHGA 

       370        380        390        400        410        420 
EGLTGIARRV HAQARALAAG LSAAGVEVVH QAFFDTVLAR VPGRTVQIQG AAKERGINVW 

       430        440        450        460        470        480 
LVDGDHVSVA CDEATTDEHI TAVLAAFAAT PARASFAGPD IATRTSAFLT HPTFTKYRTE 

       490        500        510        520        530        540 
TSMMRYLRAL ADKDIALDRS MIPLGSCTMK LNAAAEMESI TWQEFTRQHP FAPVSDTPGL 

       550        560        570        580        590        600 
RRLISDLESW LVQITGYDAV SLQPNAGSQG EYAGLLAIHD YHVSRGEPHR NVCLIPSSAH 

       610        620        630        640        650        660 
GTNAASAALV GMRVVVVGCH DNGDVDLDDL RIKLSEHANR LSVLMITYPS THGVYEHDIA 

       670        680        690        700        710        720 
EICAAVHDAG GQVYVDGANL NALVGLARPG KFGGDVSHLN LHKTFCIPHG GGGPGVGPVA 

       730        740        750        760        770        780 
VRSHLVSFLP GHPFAPELPQ GQPVSSAPYG SASLLPITWA YIRMMGADGL RTASLTAIAS 

       790        800        810        820        830        840 
ANYIARRLDK YFPVLYTGEN GMVAHECILD LRPITKSVGV TVDDVAKRLA DYGFHAPTMS 

       850        860        870        880        890        900 
FPVPGTLMVE PTESESLAEI DAFCEAMIAI RGEIARVGAG EWSVEDNPLR GAPHTAECLL 

       910        920        930        940        950 
ASDWDHPYTR EEAAYPLGKA FRPKVWPPVR RIDGVYGDRN LVCSCLPVEA FV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL008609 Genomic DNA. Translation: CAA15464.1.
AL583924 Genomic DNA. Translation: CAC31027.1.
PIRT44754.
RefSeqNP_302381.1. NC_002677.1.

3D structure databases

ProteinModelPortalO32915.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML2072.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC31027; CAC31027; CAC31027.
GeneID908561.
KEGGmle:ML2072.
PATRIC18057953. VBIMycLep78757_3900.

Organism-specific databases

LepromaML2072.
CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_MYCLE
AccessionPrimary (citable) accession number: O32915
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families