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O32915

- GCSP_MYCLE

UniProt

O32915 - GCSP_MYCLE

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Synonyms:gcvB
    Ordered Locus Names:ML2072
    ORF Names:MLCB1788.32c
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML2072.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 952952Glycine dehydrogenase (decarboxylating)PRO_0000166919Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei703 – 7031N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi272631.ML2072.

    Structurei

    3D structure databases

    ProteinModelPortaliO32915.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O32915-1 [UniParc]FASTAAdd to Basket

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    MSVPNSSNKQ TCFTARHIGP NSEDVATMLA VIGVESLDDL AAKAVPSDIL    50
    DNVTDTGVAP GLDRLPPPAT ESETLAELGA LARANTVAVS MIGQGYYDTL 100
    TPAVLSRNIL ENPAWYTPYT PYQPEISQGR LEALLNFQTL VSDLTGLEIA 150
    NASMLDEGTA AAEAMTLMYR AARSTASRVV VDVDVFAQTV AVFATRAKPL 200
    GIDIVVADLR EGLPDGEFFG VITQLPGASG RITDWTALIA QAHSRGALVA 250
    VGADLLALTL ITPPGEIGAD VAFGTTQRFG VPMGFGGPHA GYLALHTKHA 300
    RQLPGRLVGV SVDSDGTPAY RLALQTREQH IRRDKATSNI CTAQVLLAVM 350
    AAMYASYHGA EGLTGIARRV HAQARALAAG LSAAGVEVVH QAFFDTVLAR 400
    VPGRTVQIQG AAKERGINVW LVDGDHVSVA CDEATTDEHI TAVLAAFAAT 450
    PARASFAGPD IATRTSAFLT HPTFTKYRTE TSMMRYLRAL ADKDIALDRS 500
    MIPLGSCTMK LNAAAEMESI TWQEFTRQHP FAPVSDTPGL RRLISDLESW 550
    LVQITGYDAV SLQPNAGSQG EYAGLLAIHD YHVSRGEPHR NVCLIPSSAH 600
    GTNAASAALV GMRVVVVGCH DNGDVDLDDL RIKLSEHANR LSVLMITYPS 650
    THGVYEHDIA EICAAVHDAG GQVYVDGANL NALVGLARPG KFGGDVSHLN 700
    LHKTFCIPHG GGGPGVGPVA VRSHLVSFLP GHPFAPELPQ GQPVSSAPYG 750
    SASLLPITWA YIRMMGADGL RTASLTAIAS ANYIARRLDK YFPVLYTGEN 800
    GMVAHECILD LRPITKSVGV TVDDVAKRLA DYGFHAPTMS FPVPGTLMVE 850
    PTESESLAEI DAFCEAMIAI RGEIARVGAG EWSVEDNPLR GAPHTAECLL 900
    ASDWDHPYTR EEAAYPLGKA FRPKVWPPVR RIDGVYGDRN LVCSCLPVEA 950
    FV 952
    Length:952
    Mass (Da):101,283
    Last modified:January 1, 1998 - v1
    Checksum:iADC68B6265C3D8FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL008609 Genomic DNA. Translation: CAA15464.1.
    AL583924 Genomic DNA. Translation: CAC31027.1.
    PIRiT44754.
    RefSeqiNP_302381.1. NC_002677.1.
    WP_010908701.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC31027; CAC31027; CAC31027.
    GeneIDi908561.
    KEGGimle:ML2072.
    PATRICi18057953. VBIMycLep78757_3900.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL008609 Genomic DNA. Translation: CAA15464.1 .
    AL583924 Genomic DNA. Translation: CAC31027.1 .
    PIRi T44754.
    RefSeqi NP_302381.1. NC_002677.1.
    WP_010908701.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali O32915.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML2072.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC31027 ; CAC31027 ; CAC31027 .
    GeneIDi 908561.
    KEGGi mle:ML2072.
    PATRICi 18057953. VBIMycLep78757_3900.

    Organism-specific databases

    Lepromai ML2072.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiGCSP_MYCLE
    AccessioniPrimary (citable) accession number: O32915
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3