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O32915

- GCSP_MYCLE

UniProt

O32915 - GCSP_MYCLE

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, gcvB, ML2072, MLCB1788.32c
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Synonyms:gcvB
Ordered Locus Names:ML2072
ORF Names:MLCB1788.32c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML2072.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 952952Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000166919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi272631.ML2072.

Structurei

3D structure databases

ProteinModelPortaliO32915.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

O32915-1 [UniParc]FASTAAdd to Basket

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MSVPNSSNKQ TCFTARHIGP NSEDVATMLA VIGVESLDDL AAKAVPSDIL    50
DNVTDTGVAP GLDRLPPPAT ESETLAELGA LARANTVAVS MIGQGYYDTL 100
TPAVLSRNIL ENPAWYTPYT PYQPEISQGR LEALLNFQTL VSDLTGLEIA 150
NASMLDEGTA AAEAMTLMYR AARSTASRVV VDVDVFAQTV AVFATRAKPL 200
GIDIVVADLR EGLPDGEFFG VITQLPGASG RITDWTALIA QAHSRGALVA 250
VGADLLALTL ITPPGEIGAD VAFGTTQRFG VPMGFGGPHA GYLALHTKHA 300
RQLPGRLVGV SVDSDGTPAY RLALQTREQH IRRDKATSNI CTAQVLLAVM 350
AAMYASYHGA EGLTGIARRV HAQARALAAG LSAAGVEVVH QAFFDTVLAR 400
VPGRTVQIQG AAKERGINVW LVDGDHVSVA CDEATTDEHI TAVLAAFAAT 450
PARASFAGPD IATRTSAFLT HPTFTKYRTE TSMMRYLRAL ADKDIALDRS 500
MIPLGSCTMK LNAAAEMESI TWQEFTRQHP FAPVSDTPGL RRLISDLESW 550
LVQITGYDAV SLQPNAGSQG EYAGLLAIHD YHVSRGEPHR NVCLIPSSAH 600
GTNAASAALV GMRVVVVGCH DNGDVDLDDL RIKLSEHANR LSVLMITYPS 650
THGVYEHDIA EICAAVHDAG GQVYVDGANL NALVGLARPG KFGGDVSHLN 700
LHKTFCIPHG GGGPGVGPVA VRSHLVSFLP GHPFAPELPQ GQPVSSAPYG 750
SASLLPITWA YIRMMGADGL RTASLTAIAS ANYIARRLDK YFPVLYTGEN 800
GMVAHECILD LRPITKSVGV TVDDVAKRLA DYGFHAPTMS FPVPGTLMVE 850
PTESESLAEI DAFCEAMIAI RGEIARVGAG EWSVEDNPLR GAPHTAECLL 900
ASDWDHPYTR EEAAYPLGKA FRPKVWPPVR RIDGVYGDRN LVCSCLPVEA 950
FV 952
Length:952
Mass (Da):101,283
Last modified:January 1, 1998 - v1
Checksum:iADC68B6265C3D8FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL008609 Genomic DNA. Translation: CAA15464.1.
AL583924 Genomic DNA. Translation: CAC31027.1.
PIRiT44754.
RefSeqiNP_302381.1. NC_002677.1.
WP_010908701.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31027; CAC31027; CAC31027.
GeneIDi908561.
KEGGimle:ML2072.
PATRICi18057953. VBIMycLep78757_3900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL008609 Genomic DNA. Translation: CAA15464.1 .
AL583924 Genomic DNA. Translation: CAC31027.1 .
PIRi T44754.
RefSeqi NP_302381.1. NC_002677.1.
WP_010908701.1. NC_002677.1.

3D structure databases

ProteinModelPortali O32915.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML2072.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31027 ; CAC31027 ; CAC31027 .
GeneIDi 908561.
KEGGi mle:ML2072.
PATRICi 18057953. VBIMycLep78757_3900.

Organism-specific databases

Lepromai ML2072.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiGCSP_MYCLE
AccessioniPrimary (citable) accession number: O32915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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