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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Synonyms:gcvB
Ordered Locus Names:ML2072
ORF Names:MLCB1788.32c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
ProteomesiUP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2072.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 952952Glycine dehydrogenase (decarboxylating)PRO_0000166919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML2072.

Structurei

3D structure databases

ProteinModelPortaliO32915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

O32915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVPNSSNKQ TCFTARHIGP NSEDVATMLA VIGVESLDDL AAKAVPSDIL
60 70 80 90 100
DNVTDTGVAP GLDRLPPPAT ESETLAELGA LARANTVAVS MIGQGYYDTL
110 120 130 140 150
TPAVLSRNIL ENPAWYTPYT PYQPEISQGR LEALLNFQTL VSDLTGLEIA
160 170 180 190 200
NASMLDEGTA AAEAMTLMYR AARSTASRVV VDVDVFAQTV AVFATRAKPL
210 220 230 240 250
GIDIVVADLR EGLPDGEFFG VITQLPGASG RITDWTALIA QAHSRGALVA
260 270 280 290 300
VGADLLALTL ITPPGEIGAD VAFGTTQRFG VPMGFGGPHA GYLALHTKHA
310 320 330 340 350
RQLPGRLVGV SVDSDGTPAY RLALQTREQH IRRDKATSNI CTAQVLLAVM
360 370 380 390 400
AAMYASYHGA EGLTGIARRV HAQARALAAG LSAAGVEVVH QAFFDTVLAR
410 420 430 440 450
VPGRTVQIQG AAKERGINVW LVDGDHVSVA CDEATTDEHI TAVLAAFAAT
460 470 480 490 500
PARASFAGPD IATRTSAFLT HPTFTKYRTE TSMMRYLRAL ADKDIALDRS
510 520 530 540 550
MIPLGSCTMK LNAAAEMESI TWQEFTRQHP FAPVSDTPGL RRLISDLESW
560 570 580 590 600
LVQITGYDAV SLQPNAGSQG EYAGLLAIHD YHVSRGEPHR NVCLIPSSAH
610 620 630 640 650
GTNAASAALV GMRVVVVGCH DNGDVDLDDL RIKLSEHANR LSVLMITYPS
660 670 680 690 700
THGVYEHDIA EICAAVHDAG GQVYVDGANL NALVGLARPG KFGGDVSHLN
710 720 730 740 750
LHKTFCIPHG GGGPGVGPVA VRSHLVSFLP GHPFAPELPQ GQPVSSAPYG
760 770 780 790 800
SASLLPITWA YIRMMGADGL RTASLTAIAS ANYIARRLDK YFPVLYTGEN
810 820 830 840 850
GMVAHECILD LRPITKSVGV TVDDVAKRLA DYGFHAPTMS FPVPGTLMVE
860 870 880 890 900
PTESESLAEI DAFCEAMIAI RGEIARVGAG EWSVEDNPLR GAPHTAECLL
910 920 930 940 950
ASDWDHPYTR EEAAYPLGKA FRPKVWPPVR RIDGVYGDRN LVCSCLPVEA

FV
Length:952
Mass (Da):101,283
Last modified:January 1, 1998 - v1
Checksum:iADC68B6265C3D8FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL008609 Genomic DNA. Translation: CAA15464.1.
AL583924 Genomic DNA. Translation: CAC31027.1.
PIRiT44754.
RefSeqiNP_302381.1. NC_002677.1.
WP_010908701.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31027; CAC31027; CAC31027.
GeneIDi908561.
KEGGimle:ML2072.
PATRICi18057953. VBIMycLep78757_3900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL008609 Genomic DNA. Translation: CAA15464.1.
AL583924 Genomic DNA. Translation: CAC31027.1.
PIRiT44754.
RefSeqiNP_302381.1. NC_002677.1.
WP_010908701.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO32915.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2072.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31027; CAC31027; CAC31027.
GeneIDi908561.
KEGGimle:ML2072.
PATRICi18057953. VBIMycLep78757_3900.

Organism-specific databases

LepromaiML2072.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiGCSP_MYCLE
AccessioniPrimary (citable) accession number: O32915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: January 1, 1998
Last modified: June 24, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.