Reviewed,
UniProtKB/Swiss-Prot O32913 (MASZ_MYCLE)
Last modified
November 3, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Malate synthase G EC=2.3.3.9 | ||||||
| Gene names |
| ||||||
| Organism | Mycobacterium leprae [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1769 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium |
Protein attributes
| Sequence length | 731 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA. HAMAP MF_00641 |
| Pathway | Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2. HAMAP MF_00641 |
| Subunit structure | Monomer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the malate synthase family. GlcB subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glyoxylate bypass Tricarboxylic acid cycle |
| Cellular component | Cytoplasm |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glyoxylate cycle Inferred from electronic annotation. Source: HAMAP tricarboxylic acid cycleInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | malate synthase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 731 | 731 | Malate synthase G HAMAP MF_00641 | PRO_0000166888 | |||||
Sites | |||||||||
| Active site | 340 | 1 | Proton acceptor By similarity | ||||||
| Active site | 638 | 1 | Proton donor By similarity | ||||||
Sequences
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References
| [1] | "Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. Barrell B.G.Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN. |
Cross-references
Sequence databases | |
|---|---|
| AL008609 Genomic DNA. Translation: CAA15459.1. AL583924 Genomic DNA. Translation: CAC31024.1. | |
| PIR | T44752. |
| RefSeq | NP_302379.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1N8I based on UniProtKB Q50596. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 908958. |
| GenomeReviews | Gene locus ML2069 in contig AL450380_GR. |
| KEGG | mle:ML2069. |
| NMPDR | fig|272631.1.peg.1251. |
Organism-specific databases | |
| Leproma | ML2069. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | O32913. |
| OMA | PKMHGPD. |
Enzyme and pathway databases | |
| BioCyc | MLEP272631:ML2069-MON. |
| BRENDA | 2.3.3.9. 808. |
Family and domain databases | |
| HAMAP | MF_00641. [Tree] |
| InterPro | IPR011076. Malate_synth-like_core. IPR001465. Malate_synthase. IPR006253. Malate_synthG. [Graphical view] |
| PANTHER | PTHR21631:SF1. Malate_synthase. 1 hit. |
| Pfam | PF01274. Malate_synthase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01345. malate_syn_G. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MASZ_MYCLE | ||||||||
| Accession | Primary (citable) accession number: O32913 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


