ID   FPRA_MYCLE              Reviewed;         456 AA.
AC   O32886;
DT   11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 51.
DE   RecName: Full=NADPH-ferredoxin reductase fprA;
DE            Short=NFR;
DE            EC=1.18.1.2;
GN   Name=fprA; OrderedLocusNames=ML0666; ORFNames=MLCB1779.25;
OS   Mycobacterium leprae.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=1769;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   MEDLINE=21128732; PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: May serve as electron transfer protein and supply
CC       electrons to P450 systems (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2 reduced ferredoxin + NADP(+) + H(+) = 2
CC       oxidized ferredoxin + NADPH.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SIMILARITY: Belongs to the ferredoxin--NADP reductase type 1
CC       family.
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DR   EMBL; Z98271; CAB11006.1; -; Genomic_DNA.
DR   EMBL; AL583919; CAC30175.1; -; Genomic_DNA.
DR   PIR; T45314; T45314.
DR   RefSeq; NP_301540.1; -.
DR   HSSP; O05783; 1LQT.
DR   SMR; O32886; 7-456.
DR   GeneID; 910559; -.
DR   GenomeReviews; AL450380_GR; ML0666.
DR   KEGG; mle:ML0666; -.
DR   NMPDR; fig|272631.1.peg.412; -.
DR   Leproma; ML0666; -.
DR   HOGENOM; O32886; -.
DR   OMA; O32886; YHAVLLT.
DR   BioCyc; MLEP272631:ML0666-MON; -.
DR   BRENDA; 1.18.1.2; 808.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0004324; F:ferredoxin-NADP+ reductase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000759; Adrndx_reductase.
DR   InterPro; IPR013027; FAD_pyr_nucl-diS_OxRdtase.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00419; ADXRDTASE.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; NADP; Oxidoreductase.
FT   CHAIN         1    456       NADPH-ferredoxin reductase fprA.
FT                                /FTId=PRO_0000087328.
FT   NP_BIND     158    161       NADP (By similarity).
FT   NP_BIND     202    203       NADP (By similarity).
FT   NP_BIND     369    371       FAD (By similarity).
FT   BINDING      17     17       FAD; via amide nitrogen (By similarity).
FT   BINDING      43     43       FAD (By similarity).
FT   BINDING      51     51       FAD; via amide nitrogen (By similarity).
FT   BINDING      87     87       FAD; via amide nitrogen and carbonyl
FT                                oxygen (By similarity).
FT   BINDING     113    113       NADP (By similarity).
FT   BINDING     214    214       NADP (By similarity).
FT   BINDING     362    362       FAD; via amide nitrogen (By similarity).
FT   BINDING     369    369       NADP; via amide nitrogen (By similarity).
SQ   SEQUENCE   456 AA;  49630 MW;  B3506A27B4B3AC79 CRC64;
     MRPHHIHHIA IVGSGPSGFF AAASVLKAAD ASDEINVAVD MLEMLPTPWG LVRSGVAPDH
     PKIKSISKQF EKTAEDPRFR FFGNVIVGKH IEPAELAERY DAVIYAVGAQ SDRALNIPGE
     DLPGSIAAVD FVGWYNAHPN FHERSPDLSG SRAVVIGNGN VALDVTRILI TDPDVLAFTD
     IADHALESLR PRGIEEVVIV GRRGPLQTAF TTLELRELAD IEGVDVLVDP AQLEGISDEN
     AAAAGKTTRQ NIKVLRDYTV RTPKPGHRRI VFRFLTSPIE IKGKGKVERI VLGQNELVTD
     DNGRVAAKDT GVREELPAQL IVRSIGYRGV PTPGLPFDDS SVTIPNTNGR VNGSRNEYVV
     GWIKRGPTGV IGTNKKDSQD TVDTLMENLA GANDTEKFGA DHADRLAEWL AERQPKLVTS
     AHWQAIDRFE RAAGEPHGRP RVKLPNLAEL LRIGHG
//