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Protein

NADPH-ferredoxin reductase FprA

Gene

fprA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May serve as electron transfer protein and supply electrons to P450 systems.By similarity

Catalytic activityi

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei17FAD; via amide nitrogenBy similarity1
Binding sitei43FADBy similarity1
Binding sitei51FAD; via amide nitrogenBy similarity1
Binding sitei87FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei113NADPBy similarity1
Binding sitei214NADPBy similarity1
Binding sitei362FAD; via amide nitrogenBy similarity1
Binding sitei369NADP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi158 – 161NADPBy similarity4
Nucleotide bindingi202 – 203NADPBy similarity2
Nucleotide bindingi369 – 371FADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-729-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH-ferredoxin reductase FprA (EC:1.18.1.2)
Short name:
NFR
Gene namesi
Name:fprA
Ordered Locus Names:ML0666
ORF Names:MLCB1779.25
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0666

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873281 – 456NADPH-ferredoxin reductase FprAAdd BLAST456

Proteomic databases

PRIDEiO32886

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi272631.ML0666

Structurei

3D structure databases

ProteinModelPortaliO32886
SMRiO32886
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105EQH Bacteria
COG0493 LUCA
HOGENOMiHOG000249250
KOiK00528
OMAiYHAVVYC
OrthoDBiPOG091H007T

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR021163 Ferredox_Rdtase_adrenod
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PIRSFiPIRSF000362 FNR, 1 hit

Sequencei

Sequence statusi: Complete.

O32886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPHHIHHIA IVGSGPSGFF AAASVLKAAD ASDEINVAVD MLEMLPTPWG
60 70 80 90 100
LVRSGVAPDH PKIKSISKQF EKTAEDPRFR FFGNVIVGKH IEPAELAERY
110 120 130 140 150
DAVIYAVGAQ SDRALNIPGE DLPGSIAAVD FVGWYNAHPN FHERSPDLSG
160 170 180 190 200
SRAVVIGNGN VALDVTRILI TDPDVLAFTD IADHALESLR PRGIEEVVIV
210 220 230 240 250
GRRGPLQTAF TTLELRELAD IEGVDVLVDP AQLEGISDEN AAAAGKTTRQ
260 270 280 290 300
NIKVLRDYTV RTPKPGHRRI VFRFLTSPIE IKGKGKVERI VLGQNELVTD
310 320 330 340 350
DNGRVAAKDT GVREELPAQL IVRSIGYRGV PTPGLPFDDS SVTIPNTNGR
360 370 380 390 400
VNGSRNEYVV GWIKRGPTGV IGTNKKDSQD TVDTLMENLA GANDTEKFGA
410 420 430 440 450
DHADRLAEWL AERQPKLVTS AHWQAIDRFE RAAGEPHGRP RVKLPNLAEL

LRIGHG
Length:456
Mass (Da):49,630
Last modified:January 1, 1998 - v1
Checksum:iB3506A27B4B3AC79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98271 Genomic DNA Translation: CAB11006.1
AL583919 Genomic DNA Translation: CAC30175.1
PIRiT45314
RefSeqiNP_301540.1, NC_002677.1
WP_010907864.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30175; CAC30175; CAC30175
GeneIDi910559
KEGGimle:ML0666
PATRICifig|272631.5.peg.1186

Similar proteinsi

Entry informationi

Entry nameiFPRA_MYCLE
AccessioniPrimary (citable) accession number: O32886
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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