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Protein

NADPH-ferredoxin reductase FprA

Gene

fprA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May serve as electron transfer protein and supply electrons to P450 systems.By similarity

Catalytic activityi

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei17FAD; via amide nitrogenBy similarity1
Binding sitei43FADBy similarity1
Binding sitei51FAD; via amide nitrogenBy similarity1
Binding sitei87FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei113NADPBy similarity1
Binding sitei214NADPBy similarity1
Binding sitei362FAD; via amide nitrogenBy similarity1
Binding sitei369NADP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi158 – 161NADPBy similarity4
Nucleotide bindingi202 – 203NADPBy similarity2
Nucleotide bindingi369 – 371FADBy similarity3

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH-ferredoxin reductase FprA (EC:1.18.1.2)
Short name:
NFR
Gene namesi
Name:fprA
Ordered Locus Names:ML0666
ORF Names:MLCB1779.25
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0666.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873281 – 456NADPH-ferredoxin reductase FprAAdd BLAST456

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi272631.ML0666.

Structurei

3D structure databases

ProteinModelPortaliO32886.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105EQH. Bacteria.
COG0493. LUCA.
HOGENOMiHOG000249250.
KOiK00528.
OMAiNAHPNFE.
OrthoDBiPOG091H007T.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
3.50.50.60. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR021163. Ferredox_Rdtase_adrenod.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000362. FNR. 1 hit.

Sequencei

Sequence statusi: Complete.

O32886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPHHIHHIA IVGSGPSGFF AAASVLKAAD ASDEINVAVD MLEMLPTPWG
60 70 80 90 100
LVRSGVAPDH PKIKSISKQF EKTAEDPRFR FFGNVIVGKH IEPAELAERY
110 120 130 140 150
DAVIYAVGAQ SDRALNIPGE DLPGSIAAVD FVGWYNAHPN FHERSPDLSG
160 170 180 190 200
SRAVVIGNGN VALDVTRILI TDPDVLAFTD IADHALESLR PRGIEEVVIV
210 220 230 240 250
GRRGPLQTAF TTLELRELAD IEGVDVLVDP AQLEGISDEN AAAAGKTTRQ
260 270 280 290 300
NIKVLRDYTV RTPKPGHRRI VFRFLTSPIE IKGKGKVERI VLGQNELVTD
310 320 330 340 350
DNGRVAAKDT GVREELPAQL IVRSIGYRGV PTPGLPFDDS SVTIPNTNGR
360 370 380 390 400
VNGSRNEYVV GWIKRGPTGV IGTNKKDSQD TVDTLMENLA GANDTEKFGA
410 420 430 440 450
DHADRLAEWL AERQPKLVTS AHWQAIDRFE RAAGEPHGRP RVKLPNLAEL

LRIGHG
Length:456
Mass (Da):49,630
Last modified:January 1, 1998 - v1
Checksum:iB3506A27B4B3AC79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98271 Genomic DNA. Translation: CAB11006.1.
AL583919 Genomic DNA. Translation: CAC30175.1.
PIRiT45314.
RefSeqiNP_301540.1. NC_002677.1.
WP_010907864.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30175; CAC30175; CAC30175.
GeneIDi910559.
KEGGimle:ML0666.
PATRICi18052480. VBIMycLep78757_1186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98271 Genomic DNA. Translation: CAB11006.1.
AL583919 Genomic DNA. Translation: CAC30175.1.
PIRiT45314.
RefSeqiNP_301540.1. NC_002677.1.
WP_010907864.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO32886.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0666.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30175; CAC30175; CAC30175.
GeneIDi910559.
KEGGimle:ML0666.
PATRICi18052480. VBIMycLep78757_1186.

Organism-specific databases

LepromaiML0666.

Phylogenomic databases

eggNOGiENOG4105EQH. Bacteria.
COG0493. LUCA.
HOGENOMiHOG000249250.
KOiK00528.
OMAiNAHPNFE.
OrthoDBiPOG091H007T.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
3.50.50.60. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR021163. Ferredox_Rdtase_adrenod.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000362. FNR. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFPRA_MYCLE
AccessioniPrimary (citable) accession number: O32886
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.