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Reviewed, UniProtKB/Swiss-Prot O32886 (FPRA_MYCLE)

Last modified June 16, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    NADPH-ferredoxin reductase fprA
      Short name=NFR
    EC=1.18.1.2
Gene names
Name: fprA
Ordered Locus Names: ML0666
ORF Names: MLCB1779.25
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

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Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

May serve as electron transfer protein and supply electrons to P450 systems By similarity.

Catalytic activity

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.

Cofactor

FAD By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the ferredoxin--NADP reductase type 1 family.

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Ontologies

Keywords
   LigandFAD
Flavoprotein
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionelectron carrier activity

Inferred from electronic annotation. Source: InterPro

ferredoxin-NADP+ reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456NADPH-ferredoxin reductase fprA
PRO_0000087328

Regions

Nucleotide binding158 – 1614NADP By similarity
Nucleotide binding202 – 2032NADP By similarity
Nucleotide binding369 – 3713FAD By similarity

Sites

Binding site171FAD; via amide nitrogen By similarity
Binding site431FAD By similarity
Binding site511FAD; via amide nitrogen By similarity
Binding site871FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site1131NADP By similarity
Binding site2141NADP By similarity
Binding site3621FAD; via amide nitrogen By similarity
Binding site3691NADP; via amide nitrogen By similarity

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Sequences

Sequence LengthMass (Da)Tools
O32886-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: B3506A27B4B3AC79

FASTA45649,630
        10         20         30         40         50         60 
MRPHHIHHIA IVGSGPSGFF AAASVLKAAD ASDEINVAVD MLEMLPTPWG LVRSGVAPDH 

        70         80         90        100        110        120 
PKIKSISKQF EKTAEDPRFR FFGNVIVGKH IEPAELAERY DAVIYAVGAQ SDRALNIPGE 

       130        140        150        160        170        180 
DLPGSIAAVD FVGWYNAHPN FHERSPDLSG SRAVVIGNGN VALDVTRILI TDPDVLAFTD 

       190        200        210        220        230        240 
IADHALESLR PRGIEEVVIV GRRGPLQTAF TTLELRELAD IEGVDVLVDP AQLEGISDEN 

       250        260        270        280        290        300 
AAAAGKTTRQ NIKVLRDYTV RTPKPGHRRI VFRFLTSPIE IKGKGKVERI VLGQNELVTD 

       310        320        330        340        350        360 
DNGRVAAKDT GVREELPAQL IVRSIGYRGV PTPGLPFDDS SVTIPNTNGR VNGSRNEYVV 

       370        380        390        400        410        420 
GWIKRGPTGV IGTNKKDSQD TVDTLMENLA GANDTEKFGA DHADRLAEWL AERQPKLVTS 

       430        440        450 
AHWQAIDRFE RAAGEPHGRP RVKLPNLAEL LRIGHG

« Hide

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Cross-references

Sequence databases

Z98271 Genomic DNA. Translation: CAB11006.1.
AL583919 Genomic DNA. Translation: CAC30175.1.
PIRT45314.
RefSeqNP_301540.1.

3D structure databases

HSSPHSSP built from PDB template 1LQT based on UniProtKB O05783.
SMRO32886. Positions 7-456.
ModBaseSearch...

Genome annotation databases

GeneID910559.
GenomeReviewsGene locus ML0666 in contig AL450380_GR.
KEGGmle:ML0666.
NMPDRfig|272631.1.peg.412.

Organism-specific databases

LepromaML0666.
CMRSearch...

Phylogenomic databases

HOGENOMO32886.
OMAO32886. YHAVLLT.

Enzyme and pathway databases

BioCycMLEP272631:ML0666-MON.
BRENDA1.18.1.2. 808.

Family and domain databases

InterProIPR000759. Adrndx_reductase.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
[Graphical view]
PfamPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSPR00419. ADXRDTASE.
ProtoNetSearch...

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Entry information

Entry nameFPRA_MYCLE
AccessionPrimary (citable) accession number: O32886
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 1, 1998
Last modified: June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents