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Protein

Homoserine O-acetyltransferase

Gene

metX

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the methionine biosynthesis. Catalyzes the transfer of the acetyl group from acetyl-CoA to the hydroxyl group of L-homoserine to yield O-acetyl-L-homoserine.UniRule annotation

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (metX)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei157 – 1571NucleophileUniRule annotation
Active sitei320 – 3201UniRule annotation
Active sitei350 – 3501UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074.

Protein family/group databases

ESTHERimycle-metx. Homoserine_transacetylase.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferaseUniRule annotation (EC:2.3.1.31UniRule annotation)
Alternative name(s):
Homoserine O-trans-acetylaseUniRule annotation
Short name:
HTAUniRule annotation
Short name:
Homoserine transacetylaseUniRule annotation
Gene namesi
Name:metXUniRule annotation
Synonyms:metA
Ordered Locus Names:ML0682
ORF Names:MLCB1779.11
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0682.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Homoserine O-acetyltransferasePRO_0000155729Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0682.

Structurei

3D structure databases

ProteinModelPortaliO32874.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. HTA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWV. Bacteria.
COG2021. LUCA.
HOGENOMiHOG000246301.
KOiK00641.
OMAiGSVGGMN.
OrthoDBiPOG091H08NY.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_00296. Homoser_O_acetyltr. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoserine_AcTrfase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

O32874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTISKVPTQK LPAEGEVGLV DIGSLTTESG AVIDDVCIAV QRWGELSPTR
60 70 80 90 100
DNVVMVLHAL TGDSHITGPA GPGHPTPGWW DWIAGPGAPI DTNRWCAIAT
110 120 130 140 150
NVLGGCRGST GPSSLARDGK PWGSRFPLIS IRDQVEADIA ALAAMGITKV
160 170 180 190 200
AAVVGGSMGG ARALEWIIGH PDQVRAGLLL AVGVRATADQ IGTQTTQIAA
210 220 230 240 250
IKTDPNWQGG DYYETGRAPE NGLTIARRFA HLTYRSEVEL DTRFANNNQG
260 270 280 290 300
NEDPATGGRY AVQSYLEHQG DKLLARFDAG SYVVLTETLN SHDVGRGRGG
310 320 330 340 350
IGTALRGCPV PVVVGGITSD RLYPLRLQQE LAEMLPGCTG LQVVDSTYGH
360 370 380
DGFLVESEAV GKLIRQTLEL ADVGSKEDAC SQ
Length:382
Mass (Da):40,298
Last modified:January 1, 1998 - v1
Checksum:i761AF0FBC043FA3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98271 Genomic DNA. Translation: CAB10992.1.
AL583919 Genomic DNA. Translation: CAC30191.1.
PIRiT45301.
RefSeqiNP_301550.1. NC_002677.1.
WP_010907874.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30191; CAC30191; CAC30191.
GeneIDi909449.
KEGGimle:ML0682.
PATRICi18052534. VBIMycLep78757_1213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98271 Genomic DNA. Translation: CAB10992.1.
AL583919 Genomic DNA. Translation: CAC30191.1.
PIRiT45301.
RefSeqiNP_301550.1. NC_002677.1.
WP_010907874.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO32874.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0682.

Protein family/group databases

ESTHERimycle-metx. Homoserine_transacetylase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30191; CAC30191; CAC30191.
GeneIDi909449.
KEGGimle:ML0682.
PATRICi18052534. VBIMycLep78757_1213.

Organism-specific databases

LepromaiML0682.

Phylogenomic databases

eggNOGiENOG4105DWV. Bacteria.
COG2021. LUCA.
HOGENOMiHOG000246301.
KOiK00641.
OMAiGSVGGMN.
OrthoDBiPOG091H08NY.

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_00296. Homoser_O_acetyltr. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoserine_AcTrfase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMETX_MYCLE
AccessioniPrimary (citable) accession number: O32874
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.