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Protein

Homoserine O-acetyltransferase

Gene

metXA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.UniRule annotation

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (metXA)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei157NucleophileUniRule annotation1
Binding sitei227SubstrateUniRule annotation1
Active sitei320UniRule annotation1
Active sitei350UniRule annotation1
Binding sitei351SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-746-MONOMER
UniPathwayiUPA00051; UER00074

Protein family/group databases

ESTHERimycle-metx Homoserine_transacetylase

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferaseUniRule annotation (EC:2.3.1.31UniRule annotation)
Short name:
HATUniRule annotation
Alternative name(s):
Homoserine transacetylaseUniRule annotation
Short name:
HTAUniRule annotation
Gene namesi
Name:metXAUniRule annotation
Synonyms:metA
Ordered Locus Names:ML0682
ORF Names:MLCB1779.11
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0682

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001557291 – 382Homoserine O-acetyltransferaseAdd BLAST382

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0682

Structurei

3D structure databases

ProteinModelPortaliO32874
SMRiO32874
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 356AB hydrolase-1UniRule annotationAdd BLAST305

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MetX family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWV Bacteria
COG2021 LUCA
HOGENOMiHOG000246301
KOiK00641
OMAiCQGTTGP
OrthoDBiPOG091H08NY

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
HAMAPiMF_00296 MetX_acyltransf, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR008220 HAT_MetX-like
PANTHERiPTHR32268 PTHR32268, 1 hit
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF000443 Homoser_Ac_trans, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
TIGRFAMsiTIGR01392 homoserO_Ac_trn, 1 hit

Sequencei

Sequence statusi: Complete.

O32874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTISKVPTQK LPAEGEVGLV DIGSLTTESG AVIDDVCIAV QRWGELSPTR
60 70 80 90 100
DNVVMVLHAL TGDSHITGPA GPGHPTPGWW DWIAGPGAPI DTNRWCAIAT
110 120 130 140 150
NVLGGCRGST GPSSLARDGK PWGSRFPLIS IRDQVEADIA ALAAMGITKV
160 170 180 190 200
AAVVGGSMGG ARALEWIIGH PDQVRAGLLL AVGVRATADQ IGTQTTQIAA
210 220 230 240 250
IKTDPNWQGG DYYETGRAPE NGLTIARRFA HLTYRSEVEL DTRFANNNQG
260 270 280 290 300
NEDPATGGRY AVQSYLEHQG DKLLARFDAG SYVVLTETLN SHDVGRGRGG
310 320 330 340 350
IGTALRGCPV PVVVGGITSD RLYPLRLQQE LAEMLPGCTG LQVVDSTYGH
360 370 380
DGFLVESEAV GKLIRQTLEL ADVGSKEDAC SQ
Length:382
Mass (Da):40,298
Last modified:January 1, 1998 - v1
Checksum:i761AF0FBC043FA3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98271 Genomic DNA Translation: CAB10992.1
AL583919 Genomic DNA Translation: CAC30191.1
PIRiT45301
RefSeqiNP_301550.1, NC_002677.1
WP_010907874.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30191; CAC30191; CAC30191
GeneIDi909449
KEGGimle:ML0682
PATRICifig|272631.5.peg.1213

Similar proteinsi

Entry informationi

Entry nameiMETXA_MYCLE
AccessioniPrimary (citable) accession number: O32874
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: February 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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