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O32848

- PGK_MYCAV

UniProt

O32848 - PGK_MYCAV

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Protein

Phosphoglycerate kinase

Gene
pgk
Organism
Mycobacterium avium
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371Substrate By similarity
Binding sitei117 – 1171Substrate By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei215 – 2151ATP By similarity
Binding sitei303 – 3031ATP; via carbonyl oxygen By similarity
Binding sitei334 – 3341ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi363 – 3664ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
OrganismiMycobacterium avium
Taxonomic identifieri1764 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›388›388Phosphoglycerate kinasePRO_0000145963Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliO32848.
SMRiO32848. Positions 141-371.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate binding By similarity
Regioni56 – 594Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O32848-1 [UniParc]FASTAAdd to Basket

« Hide

MAVHNLKDLL AEGVSGRGVL VRSDLNVPLD SDGEQGRITD PGPDHRVGAD    50
VERTGRGGRQ GGGRRAPRAS QEWAGPGVVA GPGGRRARRA AGPARAAGLG 100
RGGHRRPGPR RGVDRRRRPA AGKHPVRRPR NVQGRRRAAR AGRQMAELVG 150
PTGAFVSDGF GVVHRKQASV YDVATLLPHY AGTLVAEEIA VLEQLTGSTK 200
RPYAVVLGGS KVSDKLGVIE SLATKADSIV IGGGMCFTFL AAQGFSVGKS 250
LVETEMVDTC RRLLDTYVDV LRLPVDMVAA DRLAADAAPQ TVPADAIPDD 300
LMGVDIGPGS VKRFTALLSN AETMFWNGPM GVFEFPAFAA GTKGLAEAIA 350
AATGKGAFSV VGGGDSAAAT AVELQLLFPL VRLIARLA 388
Length:388
Mass (Da):40,379
Last modified:June 1, 1998 - v2
Checksum:iBD5D9478DB686505
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei388 – 3881

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82749 Genomic DNA. Translation: AAB95085.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82749 Genomic DNA. Translation: AAB95085.1 .

3D structure databases

ProteinModelPortali O32848.
SMRi O32848. Positions 141-371.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mycobacterium avium glyceraldhyde-3-phosphate dehydrogenase homolog."
    Parker A.E., Bermudez L.E.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 101.

Entry informationi

Entry nameiPGK_MYCAV
AccessioniPrimary (citable) accession number: O32848
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: June 11, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3