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O32848 (PGK_MYCAV) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
OrganismMycobacterium avium
Taxonomic identifier1764 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length388 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›388›388Phosphoglycerate kinase
PRO_0000145963

Regions

Nucleotide binding363 – 3664ATP By similarity
Region24 – 263Substrate binding By similarity
Region56 – 594Substrate binding By similarity

Sites

Binding site371Substrate By similarity
Binding site1171Substrate By similarity
Binding site1651Substrate By similarity
Binding site2151ATP By similarity
Binding site3031ATP; via carbonyl oxygen By similarity
Binding site3341ATP By similarity

Experimental info

Non-terminal residue3881

Sequences

Sequence LengthMass (Da)Tools
O32848 [UniParc].

Last modified June 1, 1998. Version 2.
Checksum: BD5D9478DB686505

FASTA38840,379
        10         20         30         40         50         60 
MAVHNLKDLL AEGVSGRGVL VRSDLNVPLD SDGEQGRITD PGPDHRVGAD VERTGRGGRQ 

        70         80         90        100        110        120 
GGGRRAPRAS QEWAGPGVVA GPGGRRARRA AGPARAAGLG RGGHRRPGPR RGVDRRRRPA 

       130        140        150        160        170        180 
AGKHPVRRPR NVQGRRRAAR AGRQMAELVG PTGAFVSDGF GVVHRKQASV YDVATLLPHY 

       190        200        210        220        230        240 
AGTLVAEEIA VLEQLTGSTK RPYAVVLGGS KVSDKLGVIE SLATKADSIV IGGGMCFTFL 

       250        260        270        280        290        300 
AAQGFSVGKS LVETEMVDTC RRLLDTYVDV LRLPVDMVAA DRLAADAAPQ TVPADAIPDD 

       310        320        330        340        350        360 
LMGVDIGPGS VKRFTALLSN AETMFWNGPM GVFEFPAFAA GTKGLAEAIA AATGKGAFSV 

       370        380 
VGGGDSAAAT AVELQLLFPL VRLIARLA 

« Hide

References

[1]"Mycobacterium avium glyceraldhyde-3-phosphate dehydrogenase homolog."
Parker A.E., Bermudez L.E.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 101.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U82749 Genomic DNA. Translation: AAB95085.1.

3D structure databases

ProteinModelPortalO32848.
SMRO32848. Positions 141-371.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_MYCAV
AccessionPrimary (citable) accession number: O32848
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: February 19, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways