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Protein

Thioredoxin reductase

Gene

trxB

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448FADBy similarity
Nucleotide bindingi279 – 28810FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciLMON169963:LMO2478-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductase (EC:1.8.1.9)
Short name:
TRXR
Gene namesi
Name:trxB
Ordered Locus Names:lmo2478
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Thioredoxin reductasePRO_0000166736Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi136 ↔ 139Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO32823.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi169963.lmo2478.

Structurei

3D structure databases

ProteinModelPortaliO32823.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
HOGENOMiHOG000072911.
KOiK00384.
OMAiGQLEMNN.
OrthoDBiEOG65XN2W.
PhylomeDBiO32823.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O32823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEEKIYDV IIIGAGPAGM TAALYTSRAD LDTLMIERGV PGGQMVNTAE
60 70 80 90 100
VENYPGFDSI LGPDLSDKML SGAKQFGAEY AYGDIKEVVD GKEFKTVTAG
110 120 130 140 150
SKTYKARAII IATGAEHRKL GAAGEEELSG RGVSYCAVCD GAFFKNRELI
160 170 180 190 200
VVGGGDSAVE EGTYLTRYAD KVTIVHRRDK LRAQQILQDR AFKDEKVDFI
210 220 230 240 250
WNSTVEEIVG DGKKVTGAKL VSTVDGSESI MPVDGVFIYV GLVPLTKAFL
260 270 280 290 300
NLGITDDEGY IVTDEEMRTN LPGIFAAGDV RAKSLRQIVT ATGDGGLAGQ
310
NAQKYVEELK ESLEAEAAK
Length:319
Mass (Da):34,174
Last modified:January 1, 1998 - v1
Checksum:i8D42F36970611979
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009622 Genomic DNA. Translation: AAB63804.1.
AL591983 Genomic DNA. Translation: CAD00556.1.
PIRiAF1384.
RefSeqiNP_466001.1. NC_003210.1.
WP_003722610.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAD00556; CAD00556; CAD00556.
GeneIDi987338.
KEGGilmo:lmo2478.
PATRICi20314233. VBILisMon69206_2538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009622 Genomic DNA. Translation: AAB63804.1.
AL591983 Genomic DNA. Translation: CAD00556.1.
PIRiAF1384.
RefSeqiNP_466001.1. NC_003210.1.
WP_003722610.1. NC_003210.1.

3D structure databases

ProteinModelPortaliO32823.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo2478.

Proteomic databases

PaxDbiO32823.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD00556; CAD00556; CAD00556.
GeneIDi987338.
KEGGilmo:lmo2478.
PATRICi20314233. VBILisMon69206_2538.

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
HOGENOMiHOG000072911.
KOiK00384.
OMAiGQLEMNN.
OrthoDBiEOG65XN2W.
PhylomeDBiO32823.

Enzyme and pathway databases

BioCyciLMON169963:LMO2478-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, cloning and characterization of the Listeria monocytogenes thioredoxin reductase gene, trxB."
    Borovok I., Mislovati M., Cohen G., Aharonowitz Y.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: EGD / Serovar 1/2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiTRXB_LISMO
AccessioniPrimary (citable) accession number: O32823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: February 17, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.