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Protein

Thioredoxin reductase

Gene

trxB

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 44FADBy similarity8
Nucleotide bindingi279 – 288FADBy similarity10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciLMON169963:G1GTA-2655-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductase (EC:1.8.1.9)
Short name:
TRXR
Gene namesi
Name:trxB
Ordered Locus Names:lmo2478
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001667361 – 319Thioredoxin reductaseAdd BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi136 ↔ 139Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO32823
PRIDEiO32823

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi169963.lmo2478

Structurei

3D structure databases

ProteinModelPortaliO32823
SMRiO32823
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105C3M Bacteria
COG0492 LUCA
HOGENOMiHOG000072911
KOiK00384
OMAiDPIQGPW
PhylomeDBiO32823

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR008255 Pyr_nucl-diS_OxRdtase_2_AS
IPR000103 Pyridine_nuc-diS_OxRdtase_2
IPR005982 Thioredox_Rdtase
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PRINTSiPR00469 PNDRDTASEII
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01292 TRX_reduct, 1 hit
PROSITEiView protein in PROSITE
PS00573 PYRIDINE_REDOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O32823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEEKIYDV IIIGAGPAGM TAALYTSRAD LDTLMIERGV PGGQMVNTAE
60 70 80 90 100
VENYPGFDSI LGPDLSDKML SGAKQFGAEY AYGDIKEVVD GKEFKTVTAG
110 120 130 140 150
SKTYKARAII IATGAEHRKL GAAGEEELSG RGVSYCAVCD GAFFKNRELI
160 170 180 190 200
VVGGGDSAVE EGTYLTRYAD KVTIVHRRDK LRAQQILQDR AFKDEKVDFI
210 220 230 240 250
WNSTVEEIVG DGKKVTGAKL VSTVDGSESI MPVDGVFIYV GLVPLTKAFL
260 270 280 290 300
NLGITDDEGY IVTDEEMRTN LPGIFAAGDV RAKSLRQIVT ATGDGGLAGQ
310
NAQKYVEELK ESLEAEAAK
Length:319
Mass (Da):34,174
Last modified:January 1, 1998 - v1
Checksum:i8D42F36970611979
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009622 Genomic DNA Translation: AAB63804.1
AL591983 Genomic DNA Translation: CAD00556.1
PIRiAF1384
RefSeqiNP_466001.1, NC_003210.1
WP_003722610.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAD00556; CAD00556; CAD00556
GeneIDi987338
KEGGilmo:lmo2478
PATRICifig|169963.11.peg.2538

Similar proteinsi

Entry informationi

Entry nameiTRXB_LISMO
AccessioniPrimary (citable) accession number: O32823
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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