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Protein

Purine nucleoside phosphorylase DeoD-type

Gene

deoD

Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation
Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei5 – 51Purine nucleoside; shared with dimeric partnerBy similarity
Binding sitei21 – 211Phosphate; via amide nitrogenBy similarity
Binding sitei25 – 251PhosphateBy similarity
Binding sitei44 – 441Phosphate; shared with dimeric partnerBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciLLAC416870:GCDT-1607-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase DeoD-typeUniRule annotation (EC:2.4.2.1UniRule annotation)
Short name:
PNPUniRule annotation
Gene namesi
Name:deoDUniRule annotation
Ordered Locus Names:llmg_1599
OrganismiLactococcus lactis subsp. cremoris (strain MG1363)
Taxonomic identifieri416870 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000000364 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Purine nucleoside phosphorylase DeoD-typePRO_0000063140Add
BLAST

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi416870.llmg_1599.

Structurei

3D structure databases

ProteinModelPortaliO32810.
SMRiO32810. Positions 5-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 914Phosphate bindingBy similarity
Regioni178 – 1803Purine nucleoside bindingBy similarity
Regioni202 – 2032Purine nucleoside bindingBy similarity

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D3A. Bacteria.
COG0813. LUCA.
HOGENOMiHOG000274896.
KOiK03784.
OMAiPQCLLCG.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01627. Pur_nucleosid_phosp. 1 hit.
InterProiIPR004402. DeoD-type.
IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR00107. deoD. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O32810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTPHIEAQK GEIADKILLP GDPLRAKFIA ENFLEDAVQF NQVRGMLGFT
60 70 80 90 100
GTYKGHRVSV MGTGMGIPSI SIYANELITE YGVKRLIRVG TAGSVNEDVH
110 120 130 140 150
IRDLVIGQAA ATTSAIVRHD FPDFDFPQIA DFDLLDKAYH IAKDLGITTH
160 170 180 190 200
VGNILSSDLF YGGPDAVKVG KLGVKAVEME AAGLYYLGAK YKVQTLGIMT
210 220 230
ISDHILTGES TTSEERQLTF TDMMKVGLET LIAE
Length:234
Mass (Da):25,420
Last modified:January 1, 1998 - v1
Checksum:i02DC1608C29DE346
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80410 Genomic DNA. Translation: AAC45498.1.
AM406671 Genomic DNA. Translation: CAL98173.1.
RefSeqiWP_011675883.1. NC_009004.1.

Genome annotation databases

EnsemblBacteriaiCAL98173; CAL98173; llmg_1599.
KEGGillm:llmg_1599.
PATRICi22284368. VBILacLac4574_1639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80410 Genomic DNA. Translation: AAC45498.1.
AM406671 Genomic DNA. Translation: CAL98173.1.
RefSeqiWP_011675883.1. NC_009004.1.

3D structure databases

ProteinModelPortaliO32810.
SMRiO32810. Positions 5-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi416870.llmg_1599.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL98173; CAL98173; llmg_1599.
KEGGillm:llmg_1599.
PATRICi22284368. VBILacLac4574_1639.

Phylogenomic databases

eggNOGiENOG4105D3A. Bacteria.
COG0813. LUCA.
HOGENOMiHOG000274896.
KOiK03784.
OMAiPQCLLCG.

Enzyme and pathway databases

BioCyciLLAC416870:GCDT-1607-MONOMER.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01627. Pur_nucleosid_phosp. 1 hit.
InterProiIPR004402. DeoD-type.
IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR00107. deoD. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEOD_LACLM
AccessioniPrimary (citable) accession number: O32810
Secondary accession number(s): A2RLK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.