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Protein

DNA polymerase I

Gene

polA

Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:llmg_2425
OrganismiLactococcus lactis subsp. cremoris (strain MG1363)
Taxonomic identifieri416870 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000000364 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012441 – 877DNA polymerase IAdd BLAST877

Proteomic databases

PRIDEiO32801

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.

Protein-protein interaction databases

STRINGi416870.llmg_2425

Structurei

3D structure databases

ProteinModelPortaliO32801
SMRiO32801
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini180 – 2725'-3' exonucleaseSequence analysisAdd BLAST93
Domaini312 – 4683'-5' exonucleaseSequence analysisAdd BLAST157

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

eggNOGiENOG4105C2M Bacteria
COG0258 LUCA
COG0749 LUCA
HOGENOMiHOG000020998
KOiK02335
OMAiETGRVHT

Family and domain databases

CDDicd09898 H3TH_53EXO, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR002562 3'-5'_exonuclease_dom
IPR020046 5-3_exonucl_a-hlix_arch_N
IPR036279 5-3_exonuclease_C_sf
IPR002421 5-3_exonuclease_N
IPR019760 DNA-dir_DNA_pol_A_CS
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR020045 DNA_polI_H3TH
IPR018320 DNA_polymerase_1
IPR002298 DNA_polymerase_A
IPR008918 HhH2
IPR029060 PIN-like_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10133 PTHR10133, 1 hit
PfamiView protein in Pfam
PF01367 5_3_exonuc, 1 hit
PF02739 5_3_exonuc_N, 1 hit
PF00476 DNA_pol_A, 1 hit
PRINTSiPR00868 DNAPOLI
SMARTiView protein in SMART
SM00474 35EXOc, 1 hit
SM00475 53EXOc, 1 hit
SM00279 HhH2, 1 hit
SM00482 POLAc, 1 hit
SUPFAMiSSF47807 SSF47807, 1 hit
SSF53098 SSF53098, 1 hit
SSF88723 SSF88723, 1 hit
TIGRFAMsiTIGR00593 pola, 1 hit
PROSITEiView protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

O32801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDKNRLLLI DGSSVAFRAF FALYNQLDRF KAPNGLHTNA IFAFHTMLSS
60 70 80 90 100
LMERIQPTHV LIAFDAGKTT FRTEMFADYK GGRSKTPDEF REQLPFIKEM
110 120 130 140 150
IEKLGIRHYE LANYEADDII GTLDKMAEAP DVNFDVTIVT GDKDMIQLVD
160 170 180 190 200
GNTRVEISKK GVAEFEEFTP DYLLEKMGLT PSQFIDLKAL MGDSSDNYPG
210 220 230 240 250
VTKVGEKTGL KLLQEFGSLE NLYENVETLK ASKMKDNLIA DKEMAFLSQQ
260 270 280 290 300
LATINTKAPL EIGLEDTLLK EKNVAELGQF YDEMGFSQFK SKLLADGGGE
310 320 330 340 350
VTDETVSEEI KFEIVTDKSS VASVNADDFF YLETLGENYH REQIVAFAWG
360 370 380 390 400
NSEKIYVSKN LDLLTEMKFP ENTYDFKKNR VLLSHLNIEL PLVKFDAMLA
410 420 430 440 450
KYLISTTEDN KISTIARLFD VGHLATDEEI FGKGTKLALP DDEILFDHLA
460 470 480 490 500
RKIRVLARAK EKMMAELIEN EQEHLLSDME LPLAEVLAKM EITGISVSQN
510 520 530 540 550
TLEEIGAENE EKLASLTREI YDLAGEEFNI NSPKQLGVIL FEKLQLPVGK
560 570 580 590 600
KTKTGYSTAV DVLEDLAALS PVVAKILEYR QINKVQSTYV KGLIPQIADD
610 620 630 640 650
GKIHTRYVQD LTQTGRLSSV DPNLQNIPVR LEEGRKIRKA FVPSQDSLLL
660 670 680 690 700
SSDYSQIELR VLAHISADEH LIDAFKHGAD IHTSTAMRVF GIEKAEDVTA
710 720 730 740 750
NDRRNAKAVN FGVVYGISDF GLARNLGITR KDAKNYIETY FERYPGIKTY
760 770 780 790 800
MENIVREARD KGFVETMSHR RRKIPDINAR NFNVRGFAER TAINSPIQGS
810 820 830 840 850
AADILKIAMI NLDKALTERQ SKSKLLLQVH DEIILDVPLE ELEDIKALVK
860 870
QTMEEAIELA VPLKVDDNTG KTWYEAK
Length:877
Mass (Da):98,866
Last modified:May 1, 2007 - v2
Checksum:i214179C9CDC3A983
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti585V → E in AAB64184 (PubMed:9226255).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78771 Genomic DNA Translation: AAB64184.1
AM406671 Genomic DNA Translation: CAL98989.1
RefSeqiWP_011836063.1, NC_009004.1

Genome annotation databases

EnsemblBacteriaiCAL98989; CAL98989; llmg_2425
KEGGillm:llmg_2425

Similar proteinsi

Entry informationi

Entry nameiDPO1_LACLM
AccessioniPrimary (citable) accession number: O32801
Secondary accession number(s): A2RNU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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