ID   GPO_LACLM               Reviewed;         157 AA.
AC   O32770; A2RK72;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 49.
DE   RecName: Full=Glutathione peroxidase;
DE            EC=1.11.1.9;
GN   Name=gpo; OrderedLocusNames=llmg_1088;
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Lactococcus.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=98389648; PubMed=9721272;
RA   Martinussen J., Hammer K.;
RT   "The carB gene encoding the large subunit of carbamoylphosphate
RT   synthetase from Lactococcus lactis is transcribed monocistronically.";
RL   J. Bacteriol. 180:4380-4386(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17307855; DOI=10.1128/JB.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
CC   -!- CATALYTIC ACTIVITY: 2 glutathione + H(2)O(2) = glutathione
CC       disulfide + 2 H(2)O.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
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DR   EMBL; AJ000109; CAA03927.1; -; Genomic_DNA.
DR   EMBL; AM406671; CAL97682.1; -; Genomic_DNA.
DR   RefSeq; YP_001032402.1; -.
DR   HSSP; P00435; 1GP1.
DR   PeroxiBase; 3754; LlcGPx01_MG1363.
DR   GeneID; 4798879; -.
DR   GenomeReviews; AM406671_GR; llmg_1088.
DR   KEGG; llm:llmg_1088; -.
DR   OMA; O32770; CNQFANQ.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   PANTHER; PTHR11592; Glut_peroxidase; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Oxidoreductase; Peroxidase.
FT   CHAIN         1    157       Glutathione peroxidase.
FT                                /FTId=PRO_0000066662.
FT   ACT_SITE     35     35       By similarity.
SQ   SEQUENCE   157 AA;  17970 MW;  AD6C53806E03C7E9 CRC64;
     MNFYDFSAVK MNGETVSMSD YKGKVVIVVN TASKCGFTPQ FEGLEKLYET YKDQGLEILG
     FPCNQFANQD AGENTEINEF CQLNYGVTFT MFQKIKVNGK EAHPLYQFLK KEAKGALSGT
     IKWNFTKFLI DRDGQVIERF APKTEPEEME EEIKKLL
//