O32770 (GPO_LACLM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione peroxidase
EC=1.11.1.9

Gene names

Name:	gpo
Ordered Locus Names:	llmg_1088

Organism

Lactococcus lactis subsp. cremoris (strain MG1363) [Complete proteome] [HAMAP]

Taxonomic identifier

416870 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	157 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 157	157	Glutathione peroxidase		PRO_0000066662
Sites
	Active site	35	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O32770 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: AD6C53806E03C7E9	FASTA	157	17,970
	10 20 30 40 50 60 MNFYDFSAVK MNGETVSMSD YKGKVVIVVN TASKCGFTPQ FEGLEKLYET YKDQGLEILG 70 80 90 100 110 120 FPCNQFANQD AGENTEINEF CQLNYGVTFT MFQKIKVNGK EAHPLYQFLK KEAKGALSGT 130 140 150 IKWNFTKFLI DRDGQVIERF APKTEPEEME EEIKKLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The carB gene encoding the large subunit of carbamoylphosphate synthetase from Lactococcus lactis is transcribed monocistronically." Martinussen J., Hammer K. J. Bacteriol. 180:4380-4386(1998) [PubMed: 9721272] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363." Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J. J. Bacteriol. 189:3256-3270(2007) [PubMed: 17307855] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MG1363.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ000109 Genomic DNA. Translation: CAA03927.1. AM406671 Genomic DNA. Translation: CAL97682.1.
RefSeq	YP_001032402.1. NC_009004.1.
3D structure databases
ProteinModelPortal	O32770.
ModBase	Search...
Protein-protein interaction databases
STRING	O32770.
Protein family/group databases
PeroxiBase	3754. LlcGPx01_MG1363.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4798879.
GenomeReviews	Gene locus llmg_1088 in contig AM406671_GR.
KEGG	llm:llmg_1088.
PATRIC	22283324. VBILacLac4574_1119.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0386.
HOGENOM	HBG648990.
OMA	QEYKDQG.
ProtClustDB	CLSK824609.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K00432.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPO_LACLM

Accession

Primary (citable) accession number: O32770
Secondary accession number(s): A2RK72

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program