Copper-transporting ATPase - Helicobacter felis

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Names and origin

Protein names

Recommended name:
Copper-transporting ATPase
EC=3.6.3.4

Gene names

Name:

copA

Organism

Helicobacter felis

Taxonomic identifier

214 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

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Protein attributes

Sequence length	732 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Probably involved in copper export.
Catalytic activity	ATP + H₂O + Cu²⁺(In) = ADP + phosphate + Cu²⁺(Out).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IB subfamily. Contains 1 HMA domain.

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Ontologies

Keywords
Biological process	Copper transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Copper Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro copper ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 732

732

Copper-transporting ATPase

PRO_0000046169

Regions

Topological domain

1 – 88

88

Cytoplasmic Potential

Transmembrane

89 – 109

21

Potential

Topological domain

110 – 122

13

Extracellular Potential

Transmembrane

123 – 142

20

Potential

Topological domain

143 – 149

7

Cytoplasmic Potential

Transmembrane

150 – 170

21

Potential

Topological domain

171 – 187

17

Extracellular Potential

Transmembrane

188 – 208

21

Potential

Topological domain

209 – 336

128

Cytoplasmic Potential

Transmembrane

337 – 359

23

Potential

Topological domain

360 – 365

6

Extracellular Potential

Transmembrane

366 – 383

18

Potential

Topological domain

384 – 663

280

Cytoplasmic Potential

Transmembrane

664 – 683

20

Potential

Topological domain

684 – 694

11

Extracellular Potential

Transmembrane

695 – 713

19

Potential

Topological domain

714 – 732

19

Cytoplasmic Potential

Domain

3 – 69

67

HMA

Sites

Active site

421

1

4-aspartylphosphate intermediate By similarity

Metal binding

13

1

Copper Potential

Metal binding

16

1

Copper Potential

Metal binding

609

1

Magnesium By similarity

Metal binding

613

1

Magnesium By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

O32619-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 7105107EA5949EFD
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FASTA

732

78,853

        10         20         30         40         50         60 
MTKAQFYIEG MTCSACSSGI ERALGRKKFV QEVGVDLISK KAFVVYDENQ ASLEDVFKQI 

        70         80         90        100        110        120 
EKLGYQPRVA TDTPNTFLNP SFLTPNVKLA LVLLGTLGVL ALSMFAPLLP LPSFLKNPFI 

       130        140        150        160        170        180 
NGIVQLVLSL MVMHMGRNFY VHGFKALWAR QPNMDSLIAL GTSAALLYSL VLLFRAYTHA 

       190        200        210        220        230        240 
PIEGYYFESV CVILLFVMAG KRVEENSKDK ALEAMQSLMR HQSLNALKIE NGQSVEVPLE 

       250        260        270        280        290        300 
SLQKGDILQI LPGSYIPVDG VLFKGEAEVD ESMLSGESLP VYKKEGMDLF AGTLNTTTTF 

       310        320        330        340        350        360 
QMRATHTKAQ STLAKILTLI AKAQGSKAPI ARLADKVAGV FVPIVIGIAS IAFLVWLVLG 

       370        380        390        400        410        420 
DFTRALEVFI AILVISCPCA LGLATPMALL VAQKEASLLG LFFKDAVSLE KAKNVNHVIF 

       430        440        450        460        470        480 
DKTGTLTLGT PLVQEVRVAE GVDRLELLTL CASLEAQSEH VIAKGIVAHA KEQGIALQEV 

       490        500        510        520        530        540 
QEVQAKPGFG IKGVVGDQII KAGNLEFFNL PNPFGTLEGI QVFVGTETQI LGVVVLADSL 

       550        560        570        580        590        600 
KEGSKEAISE LKALGVKTTL LSGDNLENVR ALATQLGIQD YHAQAKPEDK LKVIQELKAQ 

       610        620        630        640        650        660 
GKVVMMVGDG VNDAPSLALS DVGVVMAKGS DASLEVADVV SFNNDIQSVV SAMKLSALTI 

       670        680        690        700        710        720 
ANIKQNLFWA FCYNSIAIPL ACGVAYKLGI MFNPMLASLA MSLSSVSVVL NAQRLRGAHF 

       730 
KIRGSHENRH SS

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References

[1]

"Properties of the P-type ATPases encoded by the copAP operons of Helicobacter pylori and Helicobacter felis."
Bayle D., Waengler S., Weitzenegger T., Steinhilber W., Volz J., Przybylski M., Schaefer K.P., Sachs G., Melchers K.
J. Bacteriol. 180:317-329(1998) [PubMed: 9440521] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 49179 / CS1 / NCTC 12436.

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Cross-references

Sequence databases
	AJ001932 Genomic DNA. Translation: CAA05104.1.
PIR	T47269.
3D structure databases
HSSP	HSSP built from PDB template 1CPZ based on UniProtKB Q47840.
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.6.3.4. 141619.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR006403. ATPase_P-typ_cat/Cu-transptr. IPR001756. ATPase_P-typ_Cu-transptr. IPR006416. ATPase_P-typ_heavy-metal. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_phosphor_site. IPR005834. Dehalogen-like_hydro. IPR017969. Heavy-metal-associated_CS. IPR006121. HeavyMe_transpt. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00943. CUATPASE.
TIGRFAMs	TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 1 hit. PS50846. HMA_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

COPA_HELFE

Accession

Primary (citable) accession number: O32619

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents