Skip Header

Contribute Send feedback
Read comments (?) or add your own

O32619 (COPA_HELFC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Copper-transporting ATPase
EC=3.6.3.4
Gene names
Name:copA
Ordered Locus Names:Hfelis_12590
OrganismHelicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1) [Complete proteome] [HAMAP]
Taxonomic identifier936155 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length732 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably involved in copper export.

Catalytic activity

ATP + H2O + Cu2+(In) = ADP + phosphate + Cu2+(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]

Contains 1 HMA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 732732Copper-transporting ATPase
PRO_0000046169

Regions

Topological domain1 – 8888Cytoplasmic Potential
Transmembrane89 – 10921Helical; Potential
Topological domain110 – 12213Extracellular Potential
Transmembrane123 – 14220Helical; Potential
Topological domain143 – 1497Cytoplasmic Potential
Transmembrane150 – 17021Helical; Potential
Topological domain171 – 18717Extracellular Potential
Transmembrane188 – 20821Helical; Potential
Topological domain209 – 336128Cytoplasmic Potential
Transmembrane337 – 35923Helical; Potential
Topological domain360 – 3656Extracellular Potential
Transmembrane366 – 38318Helical; Potential
Topological domain384 – 663280Cytoplasmic Potential
Transmembrane664 – 68320Helical; Potential
Topological domain684 – 69411Extracellular Potential
Transmembrane695 – 71319Helical; Potential
Topological domain714 – 73219Cytoplasmic Potential
Domain3 – 6967HMA

Sites

Active site42114-aspartylphosphate intermediate By similarity
Metal binding131Copper Potential
Metal binding161Copper Potential
Metal binding6091Magnesium By similarity
Metal binding6131Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
O32619 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 7105107EA5949EFD

FASTA73278,853
        10         20         30         40         50         60 
MTKAQFYIEG MTCSACSSGI ERALGRKKFV QEVGVDLISK KAFVVYDENQ ASLEDVFKQI 

        70         80         90        100        110        120 
EKLGYQPRVA TDTPNTFLNP SFLTPNVKLA LVLLGTLGVL ALSMFAPLLP LPSFLKNPFI 

       130        140        150        160        170        180 
NGIVQLVLSL MVMHMGRNFY VHGFKALWAR QPNMDSLIAL GTSAALLYSL VLLFRAYTHA 

       190        200        210        220        230        240 
PIEGYYFESV CVILLFVMAG KRVEENSKDK ALEAMQSLMR HQSLNALKIE NGQSVEVPLE 

       250        260        270        280        290        300 
SLQKGDILQI LPGSYIPVDG VLFKGEAEVD ESMLSGESLP VYKKEGMDLF AGTLNTTTTF 

       310        320        330        340        350        360 
QMRATHTKAQ STLAKILTLI AKAQGSKAPI ARLADKVAGV FVPIVIGIAS IAFLVWLVLG 

       370        380        390        400        410        420 
DFTRALEVFI AILVISCPCA LGLATPMALL VAQKEASLLG LFFKDAVSLE KAKNVNHVIF 

       430        440        450        460        470        480 
DKTGTLTLGT PLVQEVRVAE GVDRLELLTL CASLEAQSEH VIAKGIVAHA KEQGIALQEV 

       490        500        510        520        530        540 
QEVQAKPGFG IKGVVGDQII KAGNLEFFNL PNPFGTLEGI QVFVGTETQI LGVVVLADSL 

       550        560        570        580        590        600 
KEGSKEAISE LKALGVKTTL LSGDNLENVR ALATQLGIQD YHAQAKPEDK LKVIQELKAQ 

       610        620        630        640        650        660 
GKVVMMVGDG VNDAPSLALS DVGVVMAKGS DASLEVADVV SFNNDIQSVV SAMKLSALTI 

       670        680        690        700        710        720 
ANIKQNLFWA FCYNSIAIPL ACGVAYKLGI MFNPMLASLA MSLSSVSVVL NAQRLRGAHF 

       730 
KIRGSHENRH SS

« Hide

References

« Hide 'large scale' references
[1]"Properties of the P-type ATPases encoded by the copAP operons of Helicobacter pylori and Helicobacter felis."
Bayle D., Waengler S., Weitzenegger T., Steinhilber W., Volz J., Przybylski M., Schaefer K.P., Sachs G., Melchers K.
J. Bacteriol. 180:317-329(1998) [PubMed: 9440521] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 49179 / NCTC 12436 / CS1.
[2]"Comparative whole genome analysis of the carcinogenic bacterial pathogen Helicobacter felis."
Arnold A., Zigova Z., Lawley T., Falkow S., Bentley S., Aslett M., Muller A.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49179 / NCTC 12436 / CS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ001932 Genomic DNA. Translation: CAA05104.1.
FQ670179 Genomic DNA. Translation: CBY83343.1.
PIRT47269.
RefSeqYP_004073933.1. NC_014810.2.

3D structure databases

ProteinModelPortalO32619.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID10051241.
GenomeReviewsGene locus Hfelis_12590 in contig FQ670179_GR.
KEGGhfe:HFELIS_12590.
PATRIC45240453. VBIHelFel178703_1303.

Organism-specific databases

CMRSearch...

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR006403. ATPase_P-typ_cat/Cu-transptr.
IPR006404. ATPase_P-typ_Cd/Co/Hg/Pb/Zn.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR006416. ATPase_P-typ_heavy-metal.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit.
G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KOK01533.
PfamPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00943. CUATPASE.
SUPFAMSSF56784. HAD-like_dom. 1 hit.
SSF55008. HeavyMe_transpt. 1 hit.
TIGRFAMsTIGR01511. ATPase-IB1_Cu. 1 hit.
TIGR01512. ATPase-IB2_Cd. 1 hit.
TIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOPA_HELFC
AccessionPrimary (citable) accession number: O32619
Secondary accession number(s): E7A9G6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents