Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60 kDa chaperonin

Gene

groL

Organism
Neorickettsia sennetsu (Ehrlichia sennetsu)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
55 kDa major antigen
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
OrganismiNeorickettsia sennetsu (Ehrlichia sennetsu)
Taxonomic identifieri951 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 54854860 kDa chaperoninPRO_0000063366Add
BLAST

Proteomic databases

PRIDEiO32606.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi222891.NSE_0642.

Structurei

3D structure databases

ProteinModelPortaliO32606.
SMRiO32606. Positions 2-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O32606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANEVISGEQ LQRVIRDAAD LVVSSAGVTL GPEGRPVIMS KSYGGPEVTK
60 70 80 90 100
DGYKVMNQLK PEDEKVAKIV ELLNQATSQA NEKAGDGTTT ATILVGNMIK
110 120 130 140 150
NAHKHIAAQR SRMKLKSGMK RARDEVVKYI QSVAKKINSE EEIAQVGSIS
160 170 180 190 200
ANGNSEIGGK IAEAMNKVGK EGVITVEEGK GLDEFSVSVV QGMVFDRGYV
210 220 230 240 250
SPYFITNPEK MIVEFDNPYV LLANKKLSSI QPMVPLLETI VRSNRAVVII
260 270 280 290 300
AEDVEGEALT SLVLSKMRGS LKACAVKAPG FGDRRSEMLE DIRILTGAKT
310 320 330 340 350
LVSDDLGVTV ESLTVEDLGT AKSIIISKDS TTIVDGGGEK TAIEARVKQI
360 370 380 390 400
KTQIDKTTSD YDKEKLQERL AKLAGGVAVL KVGGATEVEV KERKDRVEDA
410 420 430 440 450
LHATRAAVEE GIVPGGGATL LSAIAVLEKL SSDDDDEQAG INIVKTALKA
460 470 480 490 500
PISQIVENAG EDASVITYNL LESKDPNRIF DARELKYVDA FKAGIIDPAK
510 520 530 540
VVRVALESAV SVASVLVTTE ALIVDLPTKD NGSSSMMPGG GMGGMGGF
Length:548
Mass (Da):58,229
Last modified:January 1, 1998 - v1
Checksum:iA403FFD4E844C986
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88092 Genomic DNA. Translation: AAB64090.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88092 Genomic DNA. Translation: AAB64090.1.

3D structure databases

ProteinModelPortaliO32606.
SMRiO32606. Positions 2-527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi222891.NSE_0642.

Proteomic databases

PRIDEiO32606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Ehrlichia sennetsu groE operon and antigenic properties of the GroEL homolog."
    Zhang Y., Ohashi N., Lee E.H., Tamura A., Rikihisa Y.
    FEMS Immunol. Med. Microbiol. 18:39-46(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Japan.

Entry informationi

Entry nameiCH60_NEOSE
AccessioniPrimary (citable) accession number: O32606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 11, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.