ID   GABD_DEIRA              Reviewed;         477 AA.
AC   O32507;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 64.
DE   RecName: Full=Succinate-semialdehyde dehydrogenase [NADP+];
DE            Short=SSDH;
DE            EC=1.2.1.16;
GN   Name=ssdA; OrderedLocusNames=DR_A0343;
OS   Deinococcus radiodurans.
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales;
OC   Deinococcaceae; Deinococcus.
OX   NCBI_TaxID=1299;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KD8301;
RA   Narumi I., Kong X., Du Z., Cherdchu K., Kitayama S., Watanabe H.;
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1;
RX   MEDLINE=20036896; PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus
RT   radiodurans R1.";
RL   Science 286:1571-1577(1999).
CC   -!- CATALYTIC ACTIVITY: Succinate semialdehyde + NAD(P)(+) + H(2)O =
CC       succinate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid degradation; 4-aminobutanoate degradation.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; AB003475; BAA21377.1; -; Genomic_DNA.
DR   EMBL; AE001825; AAF12439.1; -; Genomic_DNA.
DR   PIR; C75589; C75589.
DR   RefSeq; NP_285666.1; -.
DR   HSSP; P05091; 1O04.
DR   GeneID; 1798088; -.
DR   GenomeReviews; AE001825_GR; DR_A0343.
DR   KEGG; dra:DR_A0343; -.
DR   NMPDR; fig|243230.1.peg.3156; -.
DR   TIGR; DR_A0343; -.
DR   HOGENOM; O32507; -.
DR   OMA; O32507; WINHPTS.
DR   BioCyc; DRAD243230:DR_A0343-MON; -.
DR   BRENDA; 1.2.1.16; 96172.
DR   GO; GO:0009013; F:succinate-semialdehyde dehydrogenase [NAD(P...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    477       Succinate-semialdehyde dehydrogenase
FT                                [NADP+].
FT                                /FTId=PRO_0000056571.
FT   NP_BIND     218    223       NAD or NADP (By similarity).
FT   ACT_SITE    240    240       By similarity.
FT   ACT_SITE    274    274       By similarity.
SQ   SEQUENCE   477 AA;  51240 MW;  07A9D8B893F66AA7 CRC64;
     MTATPQASAR PERPFATVNP YTGETVKTFP FLESAEIPAL IERADQAYRE WGQRPVTERA
     AIMRRAAELM LERTDELASL ITLEMGKLLR EAKGEVALAA SILNYYGEQG PSFLEPKTIP
     VPQGEAAVLH APLGVLLGIE PWNYPLYQVV RFAAPNLVVG NTVLLKHSEL CPQSALALEQ
     LFHDAGVPQG AYTNLFLRIA DIEQVIAHPA VQGVSLTGSE RAGASVAELA GRHLKKCVLE
     LGGSDPFIVL DAEDLDTTVK AAATGRLSNT GQACIAAKRL MVVDDLYDEF VSRLGQTFSA
     FVPGDPADPS TRLGPLSSEQ AARDLQAQVQ DAIDKGATVV AGGQRPEHPG AFVQPTVLTD
     VTPDMRAYHE ELFGPVAVVY RVRDEDEAVA LANASTYGLG GAVFSSDLDR AQRVAERLDT
     GMVWINHPTS SAADLPFGGV KRSGFGRELS SMGMLEFTNQ KLVRAFPTKQ KPAQVAG
//