Reviewed, UniProtKB/Swiss-Prot O32507 (GABD_DEIRA)

Names and origin

Protein names

Recommended name:
    Succinate-semialdehyde dehydrogenase [NADP+]
      Short name=SSDH
    EC=1.2.1.16

Gene names

Name:	ssdA
Ordered Locus Names:	DR_A0343

Organism

Deinococcus radiodurans [Complete proteome] [HAMAP]

Taxonomic identifier

1299 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.
Pathway	Amino-acid degradation; 4-aminobutanoate degradation.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 477	477	Succinate-semialdehyde dehydrogenase [NADP+]		PRO_0000056571
Regions
	Nucleotide binding	218 – 223	6	NAD or NADP By similarity
Sites
	Active site	240	1	By similarity
	Active site	274	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O32507-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 07A9D8B893F66AA7	FASTA	477	51,240
	10 20 30 40 50 60 MTATPQASAR PERPFATVNP YTGETVKTFP FLESAEIPAL IERADQAYRE WGQRPVTERA 70 80 90 100 110 120 AIMRRAAELM LERTDELASL ITLEMGKLLR EAKGEVALAA SILNYYGEQG PSFLEPKTIP 130 140 150 160 170 180 VPQGEAAVLH APLGVLLGIE PWNYPLYQVV RFAAPNLVVG NTVLLKHSEL CPQSALALEQ 190 200 210 220 230 240 LFHDAGVPQG AYTNLFLRIA DIEQVIAHPA VQGVSLTGSE RAGASVAELA GRHLKKCVLE 250 260 270 280 290 300 LGGSDPFIVL DAEDLDTTVK AAATGRLSNT GQACIAAKRL MVVDDLYDEF VSRLGQTFSA 310 320 330 340 350 360 FVPGDPADPS TRLGPLSSEQ AARDLQAQVQ DAIDKGATVV AGGQRPEHPG AFVQPTVLTD 370 380 390 400 410 420 VTPDMRAYHE ELFGPVAVVY RVRDEDEAVA LANASTYGLG GAVFSSDLDR AQRVAERLDT 430 440 450 460 470 GMVWINHPTS SAADLPFGGV KRSGFGRELS SMGMLEFTNQ KLVRAFPTKQ KPAQVAG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Narumi I., Kong X., Du Z., Cherdchu K., Kitayama S., Watanabe H. Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: KD8301.
[2]	"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1." White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Science 286:1571-1577(1999) [PubMed: 10567266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB003475 Genomic DNA. Translation: BAA21377.1. AE001825 Genomic DNA. Translation: AAF12439.1.
PIR	C75589.
RefSeq	NP_285666.1.
3D structure databases
HSSP	HSSP built from PDB template 1O04 based on UniProtKB P05091.
ModBase	Search...
Genome annotation databases
GeneID	1798088.
GenomeReviews	Gene locus DR_A0343 in contig AE001825_GR.
KEGG	dra:DR_A0343.
NMPDR	fig|243230.1.peg.3156.
TIGR	DR_A0343.
Phylogenomic databases
HOGENOM	O32507.
OMA	O32507. WINHPTS.
Enzyme and pathway databases
BioCyc	DRAD243230:DR_A0343-MON.
BRENDA	1.2.1.16. 96172.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GABD_DEIRA

Accession

Primary (citable) accession number: O32507

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)