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Protein

Succinate-semialdehyde dehydrogenase [NADP(+)]

Gene

ssdA

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADP+ dependent oxidation of succinate semialdehyde to succinate.By similarity

Catalytic activityi

Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.

Pathwayi: 4-aminobutanoate degradation

This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei240 – 2401Proton acceptorPROSITE-ProRule annotation
Binding sitei241 – 2411NADP; via carbonyl oxygenBy similarity
Active sitei274 – 2741NucleophilePROSITE-ProRule annotation
Binding sitei371 – 3711NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi142 – 1432NADPBy similarity
Nucleotide bindingi166 – 1694NADPBy similarity
Nucleotide bindingi218 – 2192NADPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciDRAD243230:GH46-3034-MONOMER.
UniPathwayiUPA00733.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate-semialdehyde dehydrogenase [NADP(+)] (EC:1.2.1.79)
Short name:
SSDH
Gene namesi
Name:ssdA
Ordered Locus Names:DR_A0343
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Succinate-semialdehyde dehydrogenase [NADP(+)]PRO_0000056571Add
BLAST

Proteomic databases

PRIDEiO32507.

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_A0343.

Structurei

3D structure databases

ProteinModelPortaliO32507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105C26. Bacteria.
COG1012. LUCA.
HOGENOMiHOG000271513.
InParanoidiO32507.
KOiK00135.
OMAiAVEWAVF.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O32507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATPQASAR PERPFATVNP YTGETVKTFP FLESAEIPAL IERADQAYRE
60 70 80 90 100
WGQRPVTERA AIMRRAAELM LERTDELASL ITLEMGKLLR EAKGEVALAA
110 120 130 140 150
SILNYYGEQG PSFLEPKTIP VPQGEAAVLH APLGVLLGIE PWNYPLYQVV
160 170 180 190 200
RFAAPNLVVG NTVLLKHSEL CPQSALALEQ LFHDAGVPQG AYTNLFLRIA
210 220 230 240 250
DIEQVIAHPA VQGVSLTGSE RAGASVAELA GRHLKKCVLE LGGSDPFIVL
260 270 280 290 300
DAEDLDTTVK AAATGRLSNT GQACIAAKRL MVVDDLYDEF VSRLGQTFSA
310 320 330 340 350
FVPGDPADPS TRLGPLSSEQ AARDLQAQVQ DAIDKGATVV AGGQRPEHPG
360 370 380 390 400
AFVQPTVLTD VTPDMRAYHE ELFGPVAVVY RVRDEDEAVA LANASTYGLG
410 420 430 440 450
GAVFSSDLDR AQRVAERLDT GMVWINHPTS SAADLPFGGV KRSGFGRELS
460 470
SMGMLEFTNQ KLVRAFPTKQ KPAQVAG
Length:477
Mass (Da):51,240
Last modified:January 1, 1998 - v1
Checksum:i07A9D8B893F66AA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003475 Genomic DNA. Translation: BAA21377.1.
AE001825 Genomic DNA. Translation: AAF12439.1.
PIRiC75589.
RefSeqiNP_285666.1. NC_001264.1.
WP_010889602.1. NC_001264.1.

Genome annotation databases

EnsemblBacteriaiAAF12439; AAF12439; DR_A0343.
GeneIDi1798088.
KEGGidra:DR_A0343.
PATRICi21633732. VBIDeiRad64572_3235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003475 Genomic DNA. Translation: BAA21377.1.
AE001825 Genomic DNA. Translation: AAF12439.1.
PIRiC75589.
RefSeqiNP_285666.1. NC_001264.1.
WP_010889602.1. NC_001264.1.

3D structure databases

ProteinModelPortaliO32507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_A0343.

Proteomic databases

PRIDEiO32507.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF12439; AAF12439; DR_A0343.
GeneIDi1798088.
KEGGidra:DR_A0343.
PATRICi21633732. VBIDeiRad64572_3235.

Phylogenomic databases

eggNOGiENOG4105C26. Bacteria.
COG1012. LUCA.
HOGENOMiHOG000271513.
InParanoidiO32507.
KOiK00135.
OMAiAVEWAVF.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

UniPathwayiUPA00733.
BioCyciDRAD243230:GH46-3034-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Narumi I., Kong X., Du Z., Cherdchu K., Kitayama S., Watanabe H.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: KD8301.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiGABD_DEIRA
AccessioniPrimary (citable) accession number: O32507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: February 17, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.