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Protein

Succinate-semialdehyde dehydrogenase [NADP(+)]

Gene

ssdA

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADP+ dependent oxidation of succinate semialdehyde to succinate.By similarity

Catalytic activityi

Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.

Pathwayi: 4-aminobutanoate degradation

This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei240Proton acceptorPROSITE-ProRule annotation1
Binding sitei241NADP; via carbonyl oxygenBy similarity1
Active sitei274NucleophilePROSITE-ProRule annotation1
Binding sitei371NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 143NADPBy similarity2
Nucleotide bindingi166 – 169NADPBy similarity4
Nucleotide bindingi218 – 219NADPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00733

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate-semialdehyde dehydrogenase [NADP(+)] (EC:1.2.1.79)
Short name:
SSDH
Gene namesi
Name:ssdA
Ordered Locus Names:DR_A0343
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000565711 – 477Succinate-semialdehyde dehydrogenase [NADP(+)]Add BLAST477

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_A0343

Structurei

3D structure databases

ProteinModelPortaliO32507
SMRiO32507
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG1012 LUCA
HOGENOMiHOG000271513
InParanoidiO32507
KOiK00135
OMAiTYVLKHA
OrthoDBiPOG091H07R1

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

O32507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATPQASAR PERPFATVNP YTGETVKTFP FLESAEIPAL IERADQAYRE
60 70 80 90 100
WGQRPVTERA AIMRRAAELM LERTDELASL ITLEMGKLLR EAKGEVALAA
110 120 130 140 150
SILNYYGEQG PSFLEPKTIP VPQGEAAVLH APLGVLLGIE PWNYPLYQVV
160 170 180 190 200
RFAAPNLVVG NTVLLKHSEL CPQSALALEQ LFHDAGVPQG AYTNLFLRIA
210 220 230 240 250
DIEQVIAHPA VQGVSLTGSE RAGASVAELA GRHLKKCVLE LGGSDPFIVL
260 270 280 290 300
DAEDLDTTVK AAATGRLSNT GQACIAAKRL MVVDDLYDEF VSRLGQTFSA
310 320 330 340 350
FVPGDPADPS TRLGPLSSEQ AARDLQAQVQ DAIDKGATVV AGGQRPEHPG
360 370 380 390 400
AFVQPTVLTD VTPDMRAYHE ELFGPVAVVY RVRDEDEAVA LANASTYGLG
410 420 430 440 450
GAVFSSDLDR AQRVAERLDT GMVWINHPTS SAADLPFGGV KRSGFGRELS
460 470
SMGMLEFTNQ KLVRAFPTKQ KPAQVAG
Length:477
Mass (Da):51,240
Last modified:January 1, 1998 - v1
Checksum:i07A9D8B893F66AA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003475 Genomic DNA Translation: BAA21377.1
AE001825 Genomic DNA Translation: AAF12439.1
PIRiC75589
RefSeqiNP_285666.1, NC_001264.1
WP_010889602.1, NZ_CP015082.1

Genome annotation databases

EnsemblBacteriaiAAF12439; AAF12439; DR_A0343
GeneIDi1798088
KEGGidra:DR_A0343
PATRICifig|243230.17.peg.3235

Similar proteinsi

Entry informationi

Entry nameiGABD_DEIRA
AccessioniPrimary (citable) accession number: O32507
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health