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O32450

- MALQ_THEKO

UniProt

O32450 - MALQ_THEKO

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Protein

4-alpha-glucanotransferase

Gene

TK1809

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei123 – 1231NucleophileBy similarity
Active sitei214 – 2141Proton donorBy similarity

GO - Molecular functioni

  1. 4-alpha-glucanotransferase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BioCyciTKOD69014:GH72-1846-MONOMER.

Protein family/group databases

CAZyiGH57. Glycoside Hydrolase Family 57.

Names & Taxonomyi

Protein namesi
Recommended name:
4-alpha-glucanotransferase (EC:2.4.1.25)
Alternative name(s):
Amylomaltase
Disproportionating enzyme
Short name:
D-enzyme
Gene namesi
Ordered Locus Names:TK1809
OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000536: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6536534-alpha-glucanotransferasePRO_0000184576Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi69014.TK1809.

Structurei

3D structure databases

ProteinModelPortaliO32450.
SMRiO32450. Positions 2-653.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 57 family.Curated

Phylogenomic databases

eggNOGiCOG1449.
HOGENOMiHOG000223207.
InParanoidiO32450.
KOiK01176.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
3.20.110.10. 2 hits.
InterProiIPR015179. A-amylase/a-glucTrfase_C.
IPR015178. A-amylase/a-glucTrfase_central.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR028995. Glyco_hydro_57/38_cen.
IPR004300. Glyco_hydro_57_N.
[Graphical view]
PfamiPF09094. DUF1925. 1 hit.
PF09095. DUF1926. 1 hit.
PF03065. Glyco_hydro_57. 1 hit.
[Graphical view]
ProDomiPD014405. DUF1925. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

O32450 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEMVNFIFGI HNHQPLGNFG WVMESAYERS YRPFMETLEE YPNMKVAVHY
60 70 80 90 100
SGPLLEWIRD NKPEHLDLLR SLVKRGQLEI VVAGFYEPVL ASIPKEDRIV
110 120 130 140 150
QIEKLKEFAR NLGYEARGVW LTERVWQPEL VKSLRAAGID YVIVDDYHFM
160 170 180 190 200
SAGLSKDELF WPYYTEDGGE VITVFPIDEK LRYLIPFRPV DKTLEYLHSL
210 220 230 240 250
DDGDESKVAV FHDDGEKFGV WPGTYEWVYE KGWLREFFDR VSSDERINLM
260 270 280 290 300
LYSEYLQRFR PRGLVYLPIA SYFEMSEWSL PARQAKLFVE FVEELKKENK
310 320 330 340 350
FDRYRVFVRG GIWKNFFFKY PESNYMHKRM LMVSKAVRNN PEAREFILRA
360 370 380 390 400
QCNDAYWHGV FGGVYLPHLR RAVWENIIKA QSHVKTGNFV RDIDFDGRDE
410 420 430 440 450
VFIENENFYA VFKPAYGGAL FELSSKRKAV NYNDVLARRW EHYHEVPEAA
460 470 480 490 500
TPEEGGEGVA SIHELGKQIP DEIRRELAYD SHLRAILQDH FLEPETTLDE
510 520 530 540 550
YRLSRYIELG DFLTGAYNFS LIENGITLER DGSVAKRPAR VEKSVRLTED
560 570 580 590 600
GFIVDYTVRS DARALFGVEL NLAVHSVMEE PAEFEAEKFE VNDPYGIGKV
610 620 630 640 650
EIELDRRAKV WKYPIKTLSQ SESGWDFIQQ GVSYTVLFPV EGELRFRLRF

REL
Length:653
Mass (Da):76,665
Last modified:January 1, 1998 - v1
Checksum:iB0C4695613F29219
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87907 Genomic DNA. Translation: BAA22062.1.
AP006878 Genomic DNA. Translation: BAD85998.1.
RefSeqiYP_184222.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD85998; BAD85998; TK1809.
GeneIDi3235018.
KEGGitko:TK1809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87907 Genomic DNA. Translation: BAA22062.1 .
AP006878 Genomic DNA. Translation: BAD85998.1 .
RefSeqi YP_184222.1. NC_006624.1.

3D structure databases

ProteinModelPortali O32450.
SMRi O32450. Positions 2-653.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 69014.TK1809.

Protein family/group databases

CAZyi GH57. Glycoside Hydrolase Family 57.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD85998 ; BAD85998 ; TK1809 .
GeneIDi 3235018.
KEGGi tko:TK1809.

Phylogenomic databases

eggNOGi COG1449.
HOGENOMi HOG000223207.
InParanoidi O32450.
KOi K01176.

Enzyme and pathway databases

BioCyci TKOD69014:GH72-1846-MONOMER.

Family and domain databases

Gene3Di 2.70.98.10. 1 hit.
3.20.110.10. 2 hits.
InterProi IPR015179. A-amylase/a-glucTrfase_C.
IPR015178. A-amylase/a-glucTrfase_central.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR028995. Glyco_hydro_57/38_cen.
IPR004300. Glyco_hydro_57_N.
[Graphical view ]
Pfami PF09094. DUF1925. 1 hit.
PF09095. DUF1926. 1 hit.
PF03065. Glyco_hydro_57. 1 hit.
[Graphical view ]
ProDomi PD014405. DUF1925. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of the 4-alpha-glucanotransferase gene from the hyperthermophilic archaeon Pyrococcus sp. KOD1, and characterization of the enzyme."
    Tachibana Y., Fujiwara S., Takagi M., Imanaka T.
    J. Ferment. Bioeng. 83:540-548(1997)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.
  2. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiMALQ_THEKO
AccessioniPrimary (citable) accession number: O32450
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3