O32436 (MED_BACSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcriptional activator protein med

Gene names

Name:	med
Ordered Locus Names:	BSU11300

Organism

Bacillus subtilis (strain 168) [Reference proteome] [HAMAP]

Taxonomic identifier

224308 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus subtilis group › Bacillus subtilis › Bacillus subtilis subsp. subtilis

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Positive activator of the comK gene.
Subcellular location	Cell membrane; Lipid-anchor Probable.
Sequence similarities	Belongs to the BMP lipoprotein family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cell membrane Membrane
Domain	Signal
Molecular function	Activator
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 317	300	Transcriptional activator protein med		PRO_0000018009
Amino acid modifications
	Lipidation	18	1	N-palmitoyl cysteine Potential
	Lipidation	18	1	S-diacylglycerol cysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	O32436 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 2C02E39FBB869F8F	FASTA	317	35,311
	10 20 30 40 50 60 MITRLVMIFS VLLLLSGCGQ TPFKGKIEKV GMLFPDTIND LVWGTKGYKG LLNIQSKYNV 70 80 90 100 110 120 DVYYKEGVKT EEDIINAIED FHKRGVNLLY GHGSEYAEVF NLVGEDYPDM EFVISNAKAK 130 140 150 160 170 180 ADNVTSVHFS GEAMGFFGGM TAAHMSKTNQ VGVIASFTWQ PEVDGFIKGA KYENPDIEVN 190 200 210 220 230 240 TKYTDHWDDD TTAVKLYQKM KNEGADVVYP AGDGYNVPVI QQIKKDGLYA IGYVTDQSDL 250 260 270 280 290 300 GENTVLTSTV QNVDKAYEII AEQFNKGTLE GGDHYYDLNT GVVEMGTFSP LVDQDFQQRI 310 AKLIKTYNKT GELPKNE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new Bacillus subtilis gene, med, encodes a positive regulator of comK." Ogura M., Ohshiro Y., Hirao S., Tanaka T. J. Bacteriol. 179:6244-6253(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168 / CU741.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D86376 Genomic DNA. Translation: BAA22928.1. AL009126 Genomic DNA. Translation: CAB12971.2.
PIR	D69656.
RefSeq	NP_389012.2. NC_000964.3.
3D structure databases
ProteinModelPortal	O32436.
SMR	O32436. Positions 27-316.
ModBase	Search...
Protein-protein interaction databases
STRING	224308.BSU11300.
Proteomic databases
PaxDb	O32436.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB12971; CAB12971; BSU11300.
GeneID	936388.
KEGG	bsu:BSU11300.
PATRIC	18973972. VBIBacSub10457_1180.
Organism-specific databases
GenoList	BSU11300. [Micado]
Phylogenomic databases
eggNOG	COG1744.
HOGENOM	HOG000008850.
KO	K05519.
OMA	WQPEVDG.
ProtClustDB	CLSK873451.
Enzyme and pathway databases
BioCyc	BSUB:BSU11300-MONOMER.
Family and domain databases
InterPro	IPR003760. Bmp. [Graphical view]
Pfam	PF02608. Bmp. 1 hit. [Graphical view]
PROSITE	PS51257. PROKAR_LIPOPROTEIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MED_BACSU

Accession

Primary (citable) accession number: O32436

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program