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Protein
Submitted name:

Adenylate cyclase

Gene

cyaC

Organism
Arthrospira platensis (Spirulina platensis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1017 – 10171CalciumCombined sources
Metal bindingi1017 – 10171Magnesium 1Combined sources
Metal bindingi1017 – 10171Magnesium 2Combined sources
Metal bindingi1018 – 10181Calcium; via carbonyl oxygenCombined sources
Metal bindingi1018 – 10181Magnesium 1; via carbonyl oxygenCombined sources
Metal bindingi1059 – 10591Magnesium 2; via carbonyl oxygenCombined sources
Metal bindingi1061 – 10611CalciumCombined sources
Metal bindingi1061 – 10611Magnesium 1Combined sources
Metal bindingi1061 – 10611Magnesium 2Combined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Keywords - Ligandi

CalciumCombined sources, MagnesiumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BRENDAi4.6.1.1. 5828.

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclaseImported (EC:4.6.1.1Imported)
Gene namesi
Name:cyaCImported
OrganismiArthrospira platensis (Spirulina platensis)Imported
Taxonomic identifieri118562 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesArthrospira

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5755.

Interactioni

Protein-protein interaction databases

STRINGi696747.NIES39_G01210.

Chemistry

BindingDBiO32393.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WC0X-ray2.40A/B1005-1202[»]
1WC1X-ray1.93A/B/C998-1202[»]
1WC3X-ray1.90A/B1005-1202[»]
1WC4X-ray3.00A/B1005-1202[»]
1WC5X-ray2.30A/B/C/D1005-1202[»]
1WC6X-ray2.51A/B/C998-1202[»]
2BW7X-ray2.30A/B/C/D1005-1199[»]
ProteinModelPortaliO32393.
SMRiO32393. Positions 1004-1199.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO32393.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 126116Response regulatoryInterPro annotationAdd
BLAST
Domaini283 – 32745PHYTOCHROME_2InterPro annotationAdd
BLAST
Domaini569 – 783215Histidine kinaseInterPro annotationAdd
BLAST
Domaini846 – 962117Response regulatoryInterPro annotationAdd
BLAST
Domaini1012 – 1152141Guanylate cyclaseInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 3 hits.
3.30.565.10. 1 hit.
3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR011006. CheY-like_superfamily.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR029787. Nucleotide_cyclase.
IPR016132. Phyto_chromo_attachment.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00211. Guanylate_cyc. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 2 hits.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00044. CYCc. 1 hit.
SM00065. GAF. 2 hits.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 2 hits.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 2 hits.
SSF55073. SSF55073. 1 hit.
SSF55781. SSF55781. 3 hits.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50109. HIS_KIN. 1 hit.
PS50046. PHYTOCHROME_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O32393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPNRKLKP TILVVDDEPD NLDLLYRTFH REFKVLKAES GPAALKILEE
60 70 80 90 100
VGEVAVIISD QRMPYMSGTE FLSLTATQYP DSIRIILTGY TDVEDLVEAI
110 120 130 140 150
NSGKVFKYVT KPWKSDELKA IVQQGLETHN VLKSRTEELR LAQKQESLLY
160 170 180 190 200
EVTSTIRACP NSQEMLQRIV ETVGKMFEVS YCLLRSFGVG SDLIGLGAGV
210 220 230 240 250
SPTKQDITAT QGKEWFAYLA EGQNHQNSTT DNISVINNND LELRSLVWET
260 270 280 290 300
TEVMILSEGL GNDISDHDGP EWQQRRDVYQ RADIRSSLIV PLYYRQELLA
310 320 330 340 350
VLALHHTGSP RNWHEHEVQL AAGVADQAAL ALSQVRAYEQ VRELARREAL
360 370 380 390 400
VNTITNAIRS SLDPQKIFAA ITEQLGEALE VDGCALSLWS PGDEYMQCVG
410 420 430 440 450
LYNAAIKETV VETRPAALSE PDTSTTTNLP LLGVETNQSI ESDQSDDLPQ
460 470 480 490 500
SAAPISGNPV LQELIRTRAP VAIADIEQRP DSMVMLPLRS PSKALLVVPL
510 520 530 540 550
LLDGDIIGSI SLRQNHQVRH WQPSEIDMVL LVAAQAALAV QQARLYQKTR
560 570 580 590 600
QQAERLLEAD RLKTEFFQNV SHEFRTPLTL MIGPLETVVN QQQDLSLDQA
610 620 630 640 650
KIALRNSRRL LRLVNQLLDL QRFDAGRMQP SFRPCDLVEF CQQTVESFKS
660 670 680 690 700
YCDRKQINLV TNLQSCPQLY LDLERFDKVL YNLLSNAMKF TPTDGTITVS
710 720 730 740 750
LQPEGNYCRL MVKDTGIGIK QEQLPHLFER FRQAEGSANR SFEGSGLGLA
760 770 780 790 800
LVKELVELHH GRITVESEYG QGTTFTVWLQ MGNLHLPPSP LLDVPAEFDA
810 820 830 840 850
RRAAVELADV EVDLPDVQID DINLPEVLVA DGSASLTDHG QLGSNTVLVV
860 870 880 890 900
DDNPDLRRYV SMMLQNAGFN AVLAKNGADG FNKAQTYHPD VIVTDLMMPQ
910 920 930 940 950
VSGLELIRMI RSSPELRGTP IILLTAKADE DTRIEGVERG ADAYVSKPFN
960 970 980 990 1000
DRELIAEVRN LQALKAEERR VAHLNKYLTE SVLRRFLPES MVKKAAAGDL
1010 1020 1030 1040 1050
TLDLRPEPRL ITILFSDIVG FTRMSNALQS QGVAELLNEY LGEMTRAVFE
1060 1070 1080 1090 1100
NQGTVDKFVG DAIMALYGAP EEMSPSEQVR RAIATARQML VALEKLNQGW
1110 1120 1130 1140 1150
QERGLVGRNE VPPVRFRCGI HQGMAVVGLF GSQERSDFTA IGPSVNIAAR
1160 1170 1180 1190 1200
LQEATAPNSI MVSAMVAQYV PDEEIIKREF LELKGIDEPV MTCVINPNML

NQ
Length:1,202
Mass (Da):133,924
Last modified:January 1, 1998 - v1
Checksum:i275BEC0C120AFD4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49692 Genomic DNA. Translation: BAA22997.1.
PIRiT17197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49692 Genomic DNA. Translation: BAA22997.1.
PIRiT17197.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WC0X-ray2.40A/B1005-1202[»]
1WC1X-ray1.93A/B/C998-1202[»]
1WC3X-ray1.90A/B1005-1202[»]
1WC4X-ray3.00A/B1005-1202[»]
1WC5X-ray2.30A/B/C/D1005-1202[»]
1WC6X-ray2.51A/B/C998-1202[»]
2BW7X-ray2.30A/B/C/D1005-1199[»]
ProteinModelPortaliO32393.
SMRiO32393. Positions 1004-1199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi696747.NIES39_G01210.

Chemistry

BindingDBiO32393.
ChEMBLiCHEMBL5755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.

Enzyme and pathway databases

BRENDAi4.6.1.1. 5828.

Miscellaneous databases

EvolutionaryTraceiO32393.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 3 hits.
3.30.565.10. 1 hit.
3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR011006. CheY-like_superfamily.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR029787. Nucleotide_cyclase.
IPR016132. Phyto_chromo_attachment.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00211. Guanylate_cyc. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 2 hits.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00044. CYCc. 1 hit.
SM00065. GAF. 2 hits.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 2 hits.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 2 hits.
SSF55073. SSF55073. 1 hit.
SSF55781. SSF55781. 3 hits.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50109. HIS_KIN. 1 hit.
PS50046. PHYTOCHROME_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Spirulina platensis adenylate cyclase gene, cyaC, encodes a novel signal transduction protein."
    Kasahara M., Yashiro K., Sakamoto T., Ohmori M.
    Plant Cell Physiol. 38:828-836(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IAM M-135Imported.
  2. "A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen."
    Steegborn C., Litvin T.N., Hess K.C., Capper A.B., Taussig R., Buck J., Levin L.R., Wu H.
    J. Biol. Chem. 280:31754-31759(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1005-1199 IN COMPLEX WITH CALCIUM.
  3. "Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment."
    Steegborn C., Litvin T.N., Levin L.R., Buck J., Wu H.
    Nat. Struct. Mol. Biol. 12:32-37(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 1005-1202 IN COMPLEX WITH CALCIUM AND MAGNESIUM.

Entry informationi

Entry nameiO32393_ARTPT
AccessioniPrimary (citable) accession number: O32393
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.